| TEAM | OPPONENT | WEEK/ROUND | DATE | TIME (ET) | SPREAD | OVER/UNDER | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | San Francisco 49ers | +159 | @ | -191 | WK 1 | Thu, Sep 10, 2026 | 8:35 PM | +3.5 | 48.5 | |
| 2 |  | Philadelphia Eagles | -222 | vs | +184 | WK 1 | Sun, Sep 13, 2026 | 4:25 PM | -4.5 | 47.5 | |
| 3 | | Philadelphia Eagles | -219 | @ | +180 | WK 2 | Sun, Sep 20, 2026 | 1:00 PM | -4.5 | 42.5 | |
| 4 | | San Francisco 49ers | -562 | vs | +413 | WK 2 | Sun, Sep 20, 2026 | 4:25 PM | -10.5 | 46.5 | |
| 5 | | San Francisco 49ers | -613 | vs | +428 | WK 3 | Sun, Sep 27, 2026 | 4:05 PM | -11.5 | 46.5 | |
| 6 | | Philadelphia Eagles | +100 | @ | -125 | WK 3 | Mon, Sep 28, 2026 | 8:15 PM | +1.5 | 46.5 | |
| 7 | | Philadelphia Eagles | +122 | vs | -146 | WK 4 | Sun, Oct 4, 2026 | 1:00 PM | +2.5 | 47.5 | |
| 8 | | San Francisco 49ers | -151 | vs | +123 | WK 4 | Sun, Oct 4, 2026 | 4:25 PM | -2.5 | 46.5 | |
| 9 | | Philadelphia Eagles | -127 | @ | +108 | WK 5 | Sun, Oct 11, 2026 | 9:30 AM | -1.5 | 44.5 | |
| 10 | | San Francisco 49ers | +167 | @ | -212 | WK 5 | Sun, Oct 11, 2026 | 4:25 PM | +4.0 | 48.5 | |
| 11 | | Philadelphia Eagles | -315 | vs | +245 | WK 6 | Sun, Oct 18, 2026 | 1:00 PM | -6.5 | 43.5 | |
| 12 | | San Francisco 49ers | -211 | vs | +176 | WK 11 | Sun, Nov 22, 2026 | 8:20 PM | -3.5 | 47.5 | |
| 13 | | Philadelphia Eagles | +101 | @ | -121 | WK 12 | Thu, Nov 26, 2026 | 4:30 PM | +1.5 | 49.5 | |
| 14 | | Philadelphia Eagles | -139 | vs | +119 | WK 16 | Thu, Dec 24, 2026 | 8:15 PM | -2.5 | 41.5 |
Betting lines shown represent consensus, closing odds.
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More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |