The New England Patriots have a record of 31-10 versus the Bills between October 19, 2005 and October 19, 2025.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Patriots | 10/30/2005 | 1-0 |  NE | vs |  BUF | W 21-16 | 1.000 | 3 | 18 | 273 | 394 | 14.3 | |
| 2 | | Patriots | 12/11/2005 | 1-0 | NE | @ | BUF | W 35-7 | 1.000 | 5 | 32 | 494 | 183 | 68.8 | 0.0 |
| 3 | | Patriots | 9/10/2006 | 1-0 | NE | vs | BUF | W 19-17 | 1.000 | 2 | 19 | 319 | 240 | 38.5 | 100.0 |
| 4 | | Patriots | 10/22/2006 | 1-0 | NE | @ | BUF | W 28-6 | 1.000 | 4 | 18 | 265 | 255 | 53.3 | |
| 5 | | Patriots | 9/23/2007 | 1-0 | NE | vs | BUF | W 38-7 | 1.000 | 5 | 27 | 485 | 193 | 40.0 | 33.3 |
| 6 | | Patriots | 11/18/2007 | 1-0 | NE | @ | BUF | W 56-10 | 1.000 | 8 | 30 | 510 | 229 | 72.7 | 100.0 |
| 7 | | Patriots | 11/9/2008 | 1-0 | NE | vs | BUF | W 20-10 | 1.000 | 2 | 24 | 370 | 168 | 61.1 | |
| 8 | | Patriots | 12/28/2008 | 1-0 | NE | @ | BUF | W 13-0 | 1.000 | 1 | 16 | 241 | 276 | 20.0 | 100.0 |
| 9 | | Patriots | 9/14/2009 | 1-0 | NE | vs | BUF | W 25-24 | 1.000 | 3 | 28 | 441 | 276 | 62.5 | 0.0 |
| 10 | | Patriots | 12/20/2009 | 1-0 | NE | @ | BUF | W 17-10 | 1.000 | 2 | 19 | 224 | 241 | 41.7 | |
| 11 | | Patriots | 9/26/2010 | 1-0 | NE | vs | BUF | W 38-30 | 1.000 | 5 | 25 | 445 | 374 | 58.3 | |
| 12 | | Patriots | 12/26/2010 | 1-0 | NE | @ | BUF | W 34-3 | 1.000 | 4 | 20 | 348 | 369 | 47.1 | 0.0 |
| 13 | | Patriots | 9/25/2011 | 0-1 | NE | @ | BUF | L 31-34 | .000 | 4 | 30 | 495 | 448 | 33.3 | 100.0 |
| 14 | | Patriots | 1/1/2012 | 1-0 | NE | vs | BUF | W 49-21 | 1.000 | 6 | 28 | 480 | 402 | 50.0 | |
| 15 | | Patriots | 9/30/2012 | 1-0 | NE | @ | BUF | W 52-28 | 1.000 | 7 | 33 | 580 | 438 | 36.4 | |
| 16 | | Patriots | 11/11/2012 | 1-0 | NE | vs | BUF | W 37-31 | 1.000 | 4 | 27 | 347 | 481 | 58.3 | |
| 17 | | Patriots | 9/8/2013 | 1-0 | NE | @ | BUF | W 23-21 | 1.000 | 2 | 26 | 431 | 286 | 55.0 | 0.0 |
| 18 | | Patriots | 12/29/2013 | 1-0 | NE | vs | BUF | W 34-20 | 1.000 | 3 | 24 | 382 | 393 | 30.8 | |
| 19 | | Patriots | 10/12/2014 | 1-0 | NE | @ | BUF | W 37-22 | 1.000 | 4 | 22 | 396 | 336 | 46.7 | |
| 20 | | Patriots | 12/28/2014 | 0-1 | NE | vs | BUF | L 9-17 | .000 | 0 | 14 | 260 | 268 | 33.3 | 33.3 |
| 21 | | Patriots | 9/20/2015 | 1-0 | NE | @ | BUF | W 40-32 | 1.000 | 4 | 27 | 507 | 349 | 30.0 | 0.0 |
| 22 | | Patriots | 11/23/2015 | 1-0 | NE | vs | BUF | W 20-13 | 1.000 | 2 | 18 | 356 | 319 | 28.6 | |
| 23 | | Patriots | 10/2/2016 | 0-1 | NE | vs | BUF | L 0-16 | .000 | 0 | 13 | 277 | 378 | 8.3 | 66.7 |
| 24 | | Patriots | 10/30/2016 | 1-0 | NE | @ | BUF | W 41-25 | 1.000 | 5 | 23 | 357 | 376 | 69.2 | |
| 25 | | Patriots | 12/3/2017 | 1-0 | NE | @ | BUF | W 23-3 | 1.000 | 2 | 23 | 435 | 268 | 41.7 | |
| Average | .756 | 3.0 | 21.7 | 363.2 | 323.2 | 41.7 | 3.0 | ||||||||
| Total | 31-10 | .756 | 124 | 889 | 14,890 | 13,250 | 41.7 | 63.6 | |||||||
More Patriots Stats
Team Rankings
PPG
25.0
11th
OPP PPG
20.0
7th
RUSH YDS/G
91.5
27th
PASS YDS/G
253.7
7th
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Steelers 
Colts 
Jaguars 
Chargers 
Broncos | NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 4 | 2 | 0 | .667 |
 Commanders | 3 | 3 | 0 | .500 |
| NFC North | W | L | T | PCT |
 Packers | 3 | 1 | 1 | .700 |
 Lions | 4 | 2 | 0 | .667 |
| NFC South | W | L | T | PCT |
 Buccaneers | 5 | 1 | 0 | .833 |
 Falcons | 3 | 2 | 0 | .600 |
| NFC West | W | L | T | PCT |
 Rams | 5 | 2 | 0 | .714 |
 49ers | 4 | 2 | 0 | .667 |
DAL 
KC 
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