The New England Patriots have a record of 80-52-1 in the regular-season and playoffs against the Bills all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Patriots | 9/23/1960 | 0-1 | vs | L 0-13 | .000 | 0 | 18 | 284 | 233 | ||||
| 2 | | Patriots | 12/4/1960 | 0-1 | @ | L 14-38 | .000 | 2 | 13 | 167 | 271 | ||||
| 3 | | Patriots | 9/23/1961 | 1-0 | @ | W 23-21 | 1.000 | 2 | 15 | 329 | 175 | ||||
| 4 | | Patriots | 10/22/1961 | 1-0 | vs | W 52-21 | 1.000 | 7 | 18 | 437 | 275 | ||||
| 5 | | Patriots | 11/3/1962 | 0-0-1 | @ | T 28-28 | .500 | 4 | 18 | 375 | 240 | ||||
| 6 | | Patriots | 11/23/1962 | 1-0 | vs | W 21-10 | 1.000 | 3 | 15 | 319 | 255 | ||||
| 7 | | Patriots | 10/26/1963 | 0-1 | @ | L 21-28 | .000 | 3 | 15 | 305 | 350 | ||||
| 8 | | Patriots | 12/1/1963 | 1-0 | vs | W 17-7 | 1.000 | 2 | 10 | 250 | 239 | ||||
| 9 | | Patriots | 12/28/1963 | 1-0 | @ | W 26-8 | 1.000 | 2 | 16 | 375 | 286 | ||||
| 10 | | Patriots | 11/15/1964 | 1-0 | @ | W 36-28 | 1.000 | 5 | 14 | 254 | 386 | ||||
| 11 | | Patriots | 12/20/1964 | 0-1 | vs | L 14-24 | .000 | 2 | 15 | 319 | 380 | ||||
| 12 | | Patriots | 9/11/1965 | 0-1 | @ | L 7-24 | .000 | 1 | 13 | 215 | 348 | ||||
| 13 | | Patriots | 11/7/1965 | 0-1 | vs | L 7-23 | .000 | 1 | 15 | 264 | 161 | ||||
| 14 | | Patriots | 10/8/1966 | 1-0 | @ | W 20-10 | 1.000 | 2 | 12 | 286 | 321 | ||||
| 15 | | Patriots | 12/4/1966 | 1-0 | vs | W 14-3 | 1.000 | 2 | 12 | 226 | 314 | ||||
| 16 | | Patriots | 9/24/1967 | 1-0 | @ | W 23-0 | 1.000 | 2 | 13 | 265 | 241 | ||||
| 17 | | Patriots | 12/9/1967 | 0-1 | vs | L 16-44 | .000 | 2 | 9 | 150 | 252 | ||||
| 18 | | Patriots | 9/8/1968 | 1-0 | @ | W 16-7 | 1.000 | 1 | 9 | 195 | 191 | ||||
| 19 | | Patriots | 10/20/1968 | 1-0 | vs | W 23-6 | 1.000 | 2 | 11 | 299 | 203 | ||||
| 20 | | Patriots | 10/11/1969 | 0-1 | @ | L 16-23 | .000 | 2 | 14 | 248 | 364 | ||||
| 21 | | Patriots | 11/23/1969 | 1-0 | vs | W 35-21 | 1.000 | 5 | 16 | 373 | 425 | ||||
| 22 | | Patriots | 11/1/1970 | 0-1 | vs | L 10-45 | .000 | 1 | 19 | 251 | 364 | ||||
| 23 | | Patriots | 11/29/1970 | 1-0 | @ | W 14-10 | 1.000 | 2 | 10 | 167 | 325 | ||||
| 24 | | Patriots | 11/14/1971 | 1-0 | vs | W 38-33 | 1.000 | 5 | 9 | 299 | 217 | ||||
| 25 | | Patriots | 11/28/1971 | 0-1 | @ | L 20-27 | .000 | 2 | 15 | 294 | 264 | ||||
| Average | .605 | 2.6 | 18.6 | 321.8 | 312.9 | ||||||||||
| Total | 80-52-1 | .605 | 346 | 2,475 | 42,798 | 41,614 | |||||||||
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More Patriots Stats
Team Leaders 
PASS
4,394
Maye
RUSH
911
Henderson
REC
1,013
Diggs
Team Rankings
PPG
28.8
2nd
OPP PPG
18.8
4th
RUSH YDS/G
128.9
6th
PASS YDS/G
262.3
4th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |