Peyton Manning had a record of 6-13 versus the Patriots in his career.

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peyton manning career record vs new england patriots
NAMEGPRECW%CMPATTPCTYDSAVGYDS/GTDTD%INTINT%SCKSCKYRATE
Peyton ManningPeyton Manning196-13.31645372362.75,3167.4279.8435.9263.62617989.8