Peyton Manning had a passer rating of 83.2 with 3,165 yards, 24 touchdowns and 20 interceptions in 11 games versus the Patriots on the road in his career.
| NAME | DATE | TM | OPP | CMP | ATT | PCT | YDS | AVG | TD | TD% | INT | INT% | SCK | SCKY | RATE | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Peyton Manning | 9/13/1998 |  IND | @ |  NE | 21 | 33 | 63.6 | 188 | 5.7 | 1 | 3.0 | 3 | 9.1 | 2 | 15 | 51.1 |
| | Peyton Manning | 9/19/1999 | IND | @ | NE | 18 | 30 | 60.0 | 223 | 7.4 | 3 | 10.0 | 2 | 6.7 | 0 | 0 | 88.6 |
| | Peyton Manning | 10/8/2000 | IND | @ | NE | 31 | 54 | 57.4 | 334 | 6.2 | 1 | 1.9 | 3 | 5.6 | 2 | 10 | 58.7 |
| | Peyton Manning | 9/30/2001 | IND | @ | NE | 20 | 34 | 58.8 | 196 | 5.8 | 1 | 2.9 | 3 | 8.8 | 2 | 7 | 48.2 |
| | Peyton Manning | 9/9/2004 | IND | @ | NE | 16 | 29 | 55.2 | 256 | 8.8 | 2 | 6.9 | 1 | 3.4 | 1 | 12 | 93.5 |
| | Peyton Manning | 11/7/2005 | IND | @ | NE | 28 | 37 | 75.7 | 321 | 8.7 | 3 | 8.1 | 1 | 2.7 | 0 | 0 | 117.1 |
| | Peyton Manning | 11/5/2006 | IND | @ | NE | 20 | 36 | 55.6 | 326 | 9.1 | 2 | 5.6 | 1 | 2.8 | 3 | 25 | 93.1 |
| | Peyton Manning | 11/21/2010 | IND | @ | NE | 38 | 52 | 73.1 | 396 | 7.6 | 4 | 7.7 | 3 | 5.8 | 0 | 0 | 96.3 |
 | Peyton Manning | 10/7/2012 |  DEN | @ | NE | 31 | 44 | 70.5 | 337 | 7.7 | 3 | 6.8 | 0 | 0.0 | 2 | 13 | 115.4 |
| | Peyton Manning | 11/24/2013 | DEN | @ | NE | 19 | 36 | 52.8 | 150 | 4.2 | 2 | 5.6 | 1 | 2.8 | 2 | 18 | 70.4 |
| | Peyton Manning | 11/2/2014 | DEN | @ | NE | 34 | 57 | 59.6 | 438 | 7.7 | 2 | 3.5 | 2 | 3.5 | 1 | 9 | 80.9 |
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5-12
5-11-1
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6-11
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