Since 1800, Tony Richardson and Marcus Allen are tied for the most wins by a running back, with 139 wins.

rb wins leaders since 1800
Interpreted as:
rb regular-season wins leaders since 1800
RichardsonAllenNealSmithHarrisNewhouseThomasBanaszakHendersonMitchellCraigGoreByarsFaulkDorsettSprolesPaytonMcAfeeBynerStrongBrownKuhnPearson139139128123122122120120119117117116114111111110109108108107107106104
NAMEGPWRUSH YDSATTYPCRUSH YDS/GRUSH TDREC YDSRECTRGAVGREC YDS/GREC TD
Tony RichardsonTony Richardson2341391,7274294.07.4151,5432102717.36.69
Marcus AllenMarcus Allen22213912,2433,0224.155.11235,4115879.224.421
Lorenzo NealLorenzo Neal2391288072263.63.461,0861992055.54.512
Emmitt SmithEmmitt Smith22612318,3554,4094.281.21643,2245151306.314.311
Franco HarrisFranco Harris17312212,1202,9494.170.1912,2873077.413.29
Robert NewhouseRobert Newhouse1681224,7841,1604.128.5319561208.05.75
Thurman ThomasThurman Thomas18212012,0742,8774.266.3654,458472299.424.523
Pete BanaszakPete Banaszak1661203,7729643.922.7471,0221218.46.25
William HendersonWilliam Henderson1881194261233.52.352,4093202717.512.814
Brian MitchellBrian Mitchell2231171,9673885.18.8122,336255749.210.54
Roger CraigRoger Craig1651178,1891,9914.149.6564,9115668.729.817
Frank GoreFrank Gore24111616,0003,7354.366.4813,9854846968.216.518
Keith ByarsKeith Byars1851143,1098653.616.8235,6216059.330.431
Kevin FaulkKevin Faulk1611113,6078644.222.4163,7014315718.623.015
Tony DorsettTony Dorsett17311112,7392,9364.373.6773,5543988.920.513
Darren SprolesDarren Sproles1831103,5527324.919.4234,8405537488.826.432
Walter PaytonWalter Payton19010916,7263,8384.488.01104,5384929.223.915
Fred McAfeeFred McAfee1941081,2733044.26.682113506.01.10
Earnest BynerEarnest Byner2111088,2612,0953.939.2564,6055129.021.815
Mack StrongMack Strong2011079092304.04.551,4562182416.77.210
Bill BrownBill Brown1941075,8381,6493.530.1523,18328611.116.423
John KuhnJohn Kuhn1661066582173.04.019642981256.63.99
Preston PearsonPreston Pearson1551043,5319223.822.8133,02525212.019.515
Jerome BettisJerome Bettis19210213,6623,4793.971.2911,4492001007.27.53
Anthony ShermanAnthony Sherman15310073282.60.5155266888.43.64