Alvin Kamara and Gale Sayers are tied for the most points in a game, with 36 points.

the most points by a player scored against michael lebron james in a regular-season game

	NAME	PTS	DATE	TM		OPP	RUSH TD	REC TD	RET TD	TD	FGM	XPM	XP2	SFTY
1	Alvin Kamara A. Kamara	36	12/25/2020	NO	vs	MIN	6	0	0	6	0	0	0	0
2	Gale Sayers G. Sayers	36	12/12/1965	CHI	vs	SF	4	1	1	6	0	0		0
3	Paul Hornung P. Hornung	33	10/8/1961	GB	vs	BAL	3	1	0	4	1	6		0
4	Joe Mixon J. Mixon	30	11/6/2022	CIN	vs	CAR	4	1	0	5	0	0	0	0
5	Jonathan Taylor J. Taylor	30	11/21/2021	IND	@	BUF	4	1	0	5	0	0	0	0
6	Jamaal Charles J. Charles	30	12/15/2013	KC	@	OAK	1	4	0	5	0	0	0	0
7	Clinton Portis C. Portis	30	12/7/2003	DEN	vs	KC	5	0	0	5	0	0	0	0
8	Shaun Alexander S. Alexander	30	9/29/2002	SEA	vs	MIN	4	1	0	5	0	0	0	0
9	James Stewart J. Stewart	30	10/12/1997	JAX	vs	PHI	5	0	0	5	0	0	0	0
10	Jerry Rice J. Rice	30	10/14/1990	SF	@	ATL	0	5	0	5	0	0		0
11	Kellen Winslow K. Winslow	30	11/22/1981	SD	@	OAK	0	5	0	5	0	0		0
12	Paul Hornung P. Hornung	30	12/12/1965	GB	@	BAL	3	2	0	5	0	0		0
13	Cookie Gilchrist C. Gilchrist	30	12/8/1963	BUF	vs	NYJ	5	0	0	5	0	0	0	0
14	Billy Cannon B. Cannon	30	12/10/1961	HOU	@	NYT	3	2	0	5	0	0	0	0
15	Abner Haynes A. Haynes	30	11/26/1961	DLT	vs	OAK	4	1	0	5	0	0	0	0
16	Gino Cappelletti G. Cappelletti	28	12/18/1965	BOS	vs	HOU	0	2	0	2	4	4	0	0
17	Paul Hornung P. Hornung	28	9/16/1962	GB	vs	MIN	3	0	0	3	2	4		0
18	Rob Bironas R. Bironas	26	10/21/2007	TEN	@	HOU	0	0	0	0	8	2	0	0
19	George Blanda G. Blanda	26	9/18/1960	HOU	vs	LAC	3	0	0	3	1	5	0	0
20	Jay Feely J. Feely	25	12/12/2010	ARI	vs	DEN	1	0	0	1	5	4	0	0
21	Jahmyr Gibbs J. Gibbs	24	1/5/2025	DET	vs	MIN	3	1	0	4	0	0	0	0
22	Alvin Kamara A. Kamara	24	9/15/2024	NO	@	DAL	3	1	0	4	0	0	0	0
23	Christian McCaffrey C. McCaffrey	24	10/1/2023	SF	vs	ARI	3	1	0	4	0	0	0	0
24	Raheem Mostert R. Mostert	24	9/24/2023	MIA	vs	DEN	3	1	0	4	0	0	0	0
25	De'Von Achane D. Achane	24	9/24/2023	MIA	vs	DEN	2	2	0	4	0	0	0	0