Tyrann Mathieu had his most tackles in a game against the 49ers on October 1, 2017, with 12 tackles.

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	NAME	TKL	DATE	TM		OPP	AST	COMB	SCK	SCKY	INT	INT YDS	INT TD	FF	FR	FR TD
1	Tyrann Mathieu T. Mathieu	12	10/1/2017	ARI	vs	SF	0	12	1.0	3	0	0	0	0	0	0
2	Tyrann Mathieu T. Mathieu	11	11/29/2015	ARI	@	SF	2	13	0.0	0	1	15	0	0	0	0
3	Tyrann Mathieu T. Mathieu	10	10/13/2019	KC	vs	HOU	0	10	0.0	0	0	0	0	0	0	0
4	Tyrann Mathieu T. Mathieu	10	12/10/2015	ARI	vs	MIN	1	11	0.0	0	0	0	0	0	0	0
5	Tyrann Mathieu T. Mathieu	9	9/22/2013	ARI	@	NO	1	10	0.0	0	1	0	0	0	0	0
6	Tyrann Mathieu T. Mathieu	8	11/18/2018	HOU	@	WAS	1	9	1.0	7	0	0	0	0	0	0
7	Tyrann Mathieu T. Mathieu	8	9/13/2015	ARI	vs	NO	0	8	0.0	0	0	0	0	0	0	0
8	Tyrann Mathieu T. Mathieu	7	9/22/2024	NO	vs	PHI	0	7	0.0	0	1	23	0	0	0	0
9	Tyrann Mathieu T. Mathieu	7	11/12/2023	NO	@	MIN	1	8	0.0	0	0	0	0	0	0	0
10	Tyrann Mathieu T. Mathieu	7	12/5/2021	KC	vs	DEN	2	9	0.0	0	0	0	0	0	0	0
11	Tyrann Mathieu T. Mathieu	7	12/29/2019	KC	vs	LAC	0	7	0.0	0	1	0	0	0	0	0
12	Tyrann Mathieu T. Mathieu	7	9/30/2018	HOU	@	IND	0	7	0.0	0	0	0	0	0	0	0
13	Tyrann Mathieu T. Mathieu	7	9/23/2018	HOU	vs	NYG	2	9	0.0	0	0	0	0	0	0	0
14	Tyrann Mathieu T. Mathieu	7	9/11/2016	ARI	vs	NE	0	7	0.0	0	0	0	0	0	0	0
15	Tyrann Mathieu T. Mathieu	7	10/26/2015	ARI	vs	BAL	0	7	1.0	9	0	0	0	0	0	0
16	Tyrann Mathieu T. Mathieu	7	9/8/2013	ARI	@	STL	0	7	0.0	0	0	0	0	1	0	0
17	Tyrann Mathieu T. Mathieu	6	12/21/2023	NO	@	LAR	3	9	0.0	0	0	0	0	0	0	0
18	Tyrann Mathieu T. Mathieu	6	12/24/2022	NO	@	CLE	5	11	0.0	0	0	0	0	0	0	0
19	Tyrann Mathieu T. Mathieu	6	12/18/2022	NO	vs	ATL	0	6	1.0	0	0	0	0	0	0	0
20	Tyrann Mathieu T. Mathieu	6	9/19/2021	KC	@	BAL	0	6	0.0	0	2	50	1	0	0	0
21	Tyrann Mathieu T. Mathieu	6	9/10/2020	KC	vs	HOU	2	8	0.0	0	0	0	0	0	0	0
22	Tyrann Mathieu T. Mathieu	6	12/22/2019	KC	@	CHI	0	6	0.0	0	0	0	0	0	0	0
23	Tyrann Mathieu T. Mathieu	6	12/8/2019	KC	@	NE	0	6	0.0	0	0	0	0	0	0	0
24	Tyrann Mathieu T. Mathieu	6	11/4/2018	HOU	@	DEN	0	6	0.0	0	0	0	0	0	0	0
25	Tyrann Mathieu T. Mathieu	6	10/25/2018	HOU	vs	MIA	1	7	1.0	9	0	0	0	0	0	0

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Tyrann Mathieu had his most tackles in a game against the 49ers on October 1, 2017, with 12 tackles.

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