The Buffalo Bills had their highest point differential in a game versus the Browns on November 4, 1990, with a 42-point differential.
Interpreted as:
What are the bills biggest wins in a regular-season game?| TEAM | DIFF | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 42 | 11/4/1990 |  BUF | @ |  CLE | W 42-0 | 6 | 24 | 310 | 234 | ||
| 2 | | Bills | 40 | 10/3/2021 | BUF | vs |  HOU | W 40-0 | 4 | 26 | 450 | 109 | 41.7 | 50.0 |
| 3 | | Bills | 38 | 9/20/1992 | BUF | vs |  IND | W 38-0 | 5 | 24 | 380 | 140 | 50.0 | |
| 4 | | Bills | 37 | 9/23/2024 | BUF | vs |  JAX | W 47-10 | 6 | 25 | 388 | 239 | 54.5 | 100.0 |
| 5 | | Bills | 37 | 12/23/1989 | BUF | @ |  NYJ | W 37-0 | 5 | 28 | 441 | 200 | ||
| 6 | | Bills | 36 | 10/13/1991 | BUF | vs | IND | W 42-6 | 6 | 23 | 396 | 240 | 85.7 | |
| 7 | | Bills | 35 | 10/9/2022 | BUF | vs |  PIT | W 38-3 | 5 | 21 | 552 | 364 | 55.6 | |
| 8 | | Bills | 35 | 9/19/2021 | BUF | @ |  MIA | W 35-0 | 5 | 21 | 314 | 216 | 53.8 | 100.0 |
| 9 | | Bills | 35 | 11/24/2014 | BUF | vs |  NYJ | W 38-3 | 5 | 21 | 336 | 218 | 53.8 | 0.0 |
| 10 | | Bills | 35 | 11/1/1970 | BUF | @ |  BOS | W 45-10 | 6 | 18 | 364 | 251 | ||
| 11 | | Bills | 34 | 9/24/2023 | BUF | @ |  WAS | W 37-3 | 4 | 20 | 386 | 230 | 60.0 | 0.0 |
| 12 | | Bills | 34 | 9/19/2022 | BUF | vs |  TEN | W 41-7 | 5 | 23 | 414 | 187 | 38.5 | 66.7 |
| 13 | | Bills | 34 | 9/11/2011 | BUF | @ |  KC | W 41-7 | 5 | 23 | 364 | 213 | 50.0 | |
| 14 | | Bills | 34 | 12/26/2004 | BUF | @ |  SF | W 41-7 | 5 | 27 | 441 | 189 | 64.3 | 0.0 |
| 15 | | Bills | 34 | 10/30/1994 | BUF | vs | KC | W 44-10 | 5 | 17 | 357 | 266 | 35.7 | 0.0 |
| 16 | | Bills | 34 | 9/27/1992 | BUF | @ | NE | W 41-7 | 5 | 23 | 490 | 265 | 50.0 | |
| 17 | | Bills | 34 | 9/18/1966 | BUF | vs | MIA | W 58-24 | 8 | 25 | 508 | 313 | ||
| 18 | | Bills | 33 | 9/6/1992 | BUF | vs |  RAM | W 40-7 | 5 | 23 | 363 | 215 | 50.0 | |
| 19 | | Bills | 33 | 10/3/1976 | BUF | vs | KC | W 50-17 | 7 | 25 | 446 | 502 | ||
| 20 | | Bills | 32 | 9/13/1981 | BUF | @ |  BAL | W 35-3 | 5 | 26 | 430 | 147 | ||
| 21 | | Bills | 31 | 11/11/2018 | BUF | @ | NYJ | W 41-10 | 5 | 23 | 451 | 199 | 50.0 | 100.0 |
| 22 | | Bills | 31 | 9/7/2003 | BUF | vs | NE | W 31-0 | 4 | 23 | 322 | 239 | 50.0 | 0.0 |
| 23 | | Bills | 31 | 11/11/1990 | BUF | vs |  PHX | W 45-14 | 6 | 20 | 360 | 127 | ||
| 24 | | Bills | 31 | 10/22/1989 | BUF | vs | NYJ | W 34-3 | 4 | 22 | 343 | 154 | ||
| 25 | | Bills | 31 | 9/6/1981 | BUF | vs | NYJ | W 31-0 | 4 | 25 | 418 | 231 | ||
More Bills Stats
Team Rankings
PPG
30.6
3rd
OPP PPG
22.6
17th
RUSH YDS/G
154.4
2nd
PASS YDS/G
249.8
11th
ATL 
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Division Standings
Bengals 
Chargers 
Broncos | NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 4 | 2 | 0 | .667 |
| Commanders | 3 | 2 | 0 | .600 |
| NFC North | W | L | T | PCT |
 Packers | 3 | 1 | 1 | .700 |
 Lions | 4 | 2 | 0 | .667 |
| NFC South | W | L | T | PCT |
 Buccaneers | 5 | 1 | 0 | .833 |
 Panthers | 3 | 3 | 0 | .500 |
| NFC West | W | L | T | PCT |
| 49ers | 4 | 2 | 0 | .667 |
 Seahawks | 4 | 2 | 0 | .667 |
DAL 
LV 
CHI 
LAR 
