The Indianapolis Colts have an 8-3 record as favorites against the NFC South in the regular-season and playoffs at home all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Colts | 10/12/2003 | 0-1 | vs | L 20-23 | .000 | 2 | 20 | 369 | 341 | 25.0 | 100.0 | ||
| 2 | | Colts | 12/14/2003 | 1-0 | vs | W 38-7 | 1.000 | 5 | 27 | 465 | 154 | 50.0 | 0.0 | ||
| 3 | | Colts | 9/6/2007 | 1-0 | vs | W 41-10 | 1.000 | 5 | 20 | 452 | 293 | 36.4 | |||
| 4 | | Colts | 10/7/2007 | 1-0 | vs | W 33-14 | 1.000 | 4 | 28 | 400 | 177 | 75.0 | 100.0 | ||
| 5 | | Colts | 2/7/2010 | 0-1 | vs | L 17-31 | .000 | 2 | 23 | 432 | 332 | 46.2 | 50.0 | ||
| 6 | | Colts | 10/25/2015 | 0-1 | vs | L 21-27 | .000 | 3 | 15 | 376 | 449 | 23.1 | |||
| 7 | | Colts | 11/29/2015 | 1-0 | vs | W 25-12 | 1.000 | 2 | 23 | 336 | 344 | 43.8 | |||
| 8 | | Colts | 9/22/2019 | 1-0 | vs | W 27-24 | 1.000 | 3 | 29 | 379 | 397 | 62.5 | |||
| 9 | | Colts | 12/22/2019 | 1-0 | vs | W 38-6 | 1.000 | 5 | 25 | 324 | 286 | 36.4 | 50.0 | ||
| 10 | | Colts | 11/26/2023 | 1-0 | vs | W 27-20 | 1.000 | 3 | 26 | 394 | 298 | 18.2 | 75.0 | ||
| 11 | | Colts | 11/9/2025 | 1-0 | vs | W 31-25 | 1.000 | 4 | 25 | 519 | 290 | 16.7 | 50.0 | ||
| Average | .727 | 3.5 | 23.7 | 404.2 | 305.5 | 40.0 | 8.6 | ||||||||
| Total | 8-3 | .727 | 38 | 261 | 4,446 | 3,361 | 40.0 | 60.0 |
IND
CAR
TBMore Colts Stats
Team Leaders 
PASS
3,101
Jones
RUSH
1,443
Taylor
REC
785
Pierce
Team Rankings
PPG
28.0
6th
OPP PPG
21.6
12th
RUSH YDS/G
128.9
6th
PASS YDS/G
241.1
9th
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SF
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
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NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
11 | 3 | 0 | .786 | |
10 | 4 | 0 | .714 | |
 Dolphins - e | 6 | 8 | 0 | .429 |
 Jets - e | 3 | 11 | 0 | .214 |
| AFC North | W | L | T | PCT |
8 | 6 | 0 | .571 | |
7 | 7 | 0 | .500 | |
 Bengals - e | 4 | 10 | 0 | .286 |
 Browns - e | 3 | 11 | 0 | .214 |
| AFC South | W | L | T | PCT |
10 | 4 | 0 | .714 | |
9 | 5 | 0 | .643 | |
8 | 6 | 0 | .571 | |
 Titans - e | 2 | 12 | 0 | .143 |
| AFC West | W | L | T | PCT |
 Broncos - x | 12 | 2 | 0 | .857 |
10 | 4 | 0 | .714 | |
 Chiefs - e | 6 | 8 | 0 | .429 |
 Raiders - e | 2 | 12 | 0 | .143 |
Patriots
Bills
Steelers
Ravens
Chargers| NFC East | W | L | T | PCT |
|---|---|---|---|---|
9 | 5 | 0 | .643 | |
6 | 7 | 1 | .464 | |
 Commanders - e | 4 | 10 | 0 | .286 |
 Giants - e | 2 | 12 | 0 | .143 |
| NFC North | W | L | T | PCT |
10 | 4 | 0 | .714 | |
9 | 4 | 1 | .679 | |
8 | 6 | 0 | .571 | |
 Vikings - e | 6 | 8 | 0 | .429 |
| NFC South | W | L | T | PCT |
7 | 7 | 0 | .500 | |
7 | 7 | 0 | .500 | |
 Falcons - e | 5 | 9 | 0 | .357 |
 Saints - e | 4 | 10 | 0 | .286 |
| NFC West | W | L | T | PCT |
 Rams - x | 11 | 3 | 0 | .786 |
11 | 3 | 0 | .786 | |
10 | 4 | 0 | .714 | |
 Cardinals - e | 3 | 11 | 0 | .214 |
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