Peyton Manning had the most games by a quarterback with 450+ passing yards and 4+ passing touchdowns, with 3 games.

which qb has the most games with 450 passing yards and 4 tds
Interpreted as:
Which qb has the most regular-season games with 450 or more passing yards and 4 or more passing tds?
ManningWinstonBreesMarinoKramerPrescottFolesMahomesLuckGoffWilsonCarrRyanRoethlisbergerRomoRodgersManningSchaubFlynnStaffordBradyCasselVolek32222111111111111111111
NAMEGPYDSTDCMPATTPCTAVGYDS/GTD%INTINT%SCKSCKYRATE
Peyton ManningPeyton Manning31,413168313362.410.6471.012.032.3420128.5
Jameis WinstonJameis Winston29148618770.110.5457.09.244.6319115.8
Drew BreesDrew Brees297011739973.79.8485.011.133.015128.8
Dan MarinoDan Marino29439589958.69.5471.59.133.0553108.3
Tommy KramerTommy Kramer29468588469.011.3473.09.511.2133.3
Dak PrescottDak Prescott15024415870.78.7502.06.911.7321112.9
Nick FolesNick Foles14714354971.49.6471.08.212.019120.4
Patrick MahomesPatrick Mahomes14786334671.710.4478.013.036.5330117.6
Andrew LuckAndrew Luck14644406264.57.5464.06.500.0427108.5
Jared GoffJared Goff14655263378.814.1465.015.200.019158.3
Russell WilsonRussell Wilson14524264163.411.0452.09.812.426123.2
Derek CarrDerek Carr15134405967.88.7513.06.800.0215117.4
Matt RyanMatt Ryan15034283775.713.6503.010.812.7322142.0
Ben RoethlisbergerBen Roethlisberger15226404981.610.7522.012.200.000150.6
Tony RomoTony Romo15065253669.414.1506.013.912.8436140.0
Aaron RodgersAaron Rodgers14804344281.011.4480.09.500.0439146.0
Eli ManningEli Manning14504274264.310.7450.09.537.1322102.3
Matt SchaubMatt Schaub15275435578.29.6527.09.123.6223121.7
Matt FlynnMatt Flynn14806314470.510.9480.013.612.3311136.4
Matthew StaffordMatthew Stafford15205365961.08.8520.08.523.4218103.8
Tom BradyTom Brady15174324866.710.8517.08.312.111121.6
Matt CasselMatt Cassel14694335362.38.8469.07.500.0436116.0
Billy VolekBilly Volek14924406066.78.2492.06.711.7326107.1
Donovan McNabbDonovan McNabb14645324374.410.8464.011.600.0415147.8
Jake PlummerJake Plummer14994315556.49.1499.07.335.50088.4
StatMuse has game-level data for passing touchdowns and passing yards going back to the 1950 season.

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