which rb has the most games with 250 yards

O.J. Simpson had the most games by a running back with 250+ rushing yards, with 2 games.

Interpreted as:
Which rb has the most regular-season games with 250 or more rushing yards?
NAMEGPRUSH YDSATTYPCRUSH YDS/GRUSH TDREC YDSRECTRGAVGREC YDS/GREC TD
1O.J. Simpson
O.J. Simpson
2
523
58
9.0
261.5
4
0
0
0.0
0
2Saquon Barkley
S. Barkley
1
255
26
9.8
255.0
2
47
4
4
11.8
47.0
0
3Derrick Henry
D. Henry
1
250
34
7.4
250.0
2
0
0
0
0.0
0
4Jonathan Taylor
J. Taylor
1
253
30
8.4
253.0
2
1
1
2
1.0
1.0
0
5Doug Martin
D. Martin
1
251
25
10.0
251.0
4
21
4
5
5.3
21.0
0
6DeMarco Murray
D. Murray
1
253
25
10.1
253.0
1
0
0
2
0.0
0
7Jamaal Charles
J. Charles
1
259
25
10.4
259.0
2
3
1
1
3.0
3.0
0
8Jerome Harrison
J. Harrison
1
286
34
8.4
286.0
3
12
2
3
6.0
12.0
0
9Adrian Peterson
A. Peterson
1
296
30
9.9
296.0
3
19
1
2
19.0
19.0
0
10Jamal Lewis
J. Lewis
1
295
30
9.8
295.0
2
0
0
1
0.0
0
11Shaun Alexander
S. Alexander
1
266
35
7.6
266.0
3
7
1
1
7.0
7.0
0
12Mike Anderson
M. Anderson
1
251
37
6.8
251.0
4
5
1
1
5.0
5.0
0
13Corey Dillon
C. Dillon
1
278
22
12.6
278.0
2
0
0
0
0.0
0
14Walter Payton
W. Payton
1
275
40
6.9
275.0
1
6
1
6.0
6.0
0
StatMuse has game-level data for rushing yards going back to the 1960 season.

More Bills Stats

Team Leaders

PASS

3,668

Allen

Josh Allen

RUSH

1,606

Cook

James Cook III

REC

719

Shakir

Khalil Shakir
Team Rankings

PPG

27.9

6th

OPP PPG

22.3

13th

RUSH YDS/G

156.4

2nd

PASS YDS/G

232.6

18th

2025 Division Standings
TEAMWLTPCT
13
3
0
.813
Bills Bills
11
5
0
.688
7
9
0
.438
3
13
0
.188
Schedule
DATEMATCHUPTIME (ET)
Sun
1/4
@
4:25 PM
Last Game
PHI Eagles

11 - 5

13

Final

12

BUF Bills

11 - 5

Sun 28 Dec 2025

NFL 2025 Leaders

NFL 2025 Rankings

NFL Fantasy 2025

NFL 2025 Betting

NFL 2025 Standings

NFC EastWLTPCT
11
5
0
.688
7
8
1
.469
4
12
0
.250
3
13
0
.188
NFC NorthWLTPCT
Bears Bears - y
11
5
0
.688
9
6
1
.594
8
8
0
.500
Lions Lions - e
8
8
0
.500
NFC SouthWLTPCT
8
9
0
.471
8
9
0
.471
7
9
0
.438
6
10
0
.375
NFC WestWLTPCT
14
3
0
.824
49ers 49ers - w
12
5
0
.706
Rams Rams - w
11
5
0
.688
3
13
0
.188
AFC EastWLTPCT
13
3
0
.813
Bills Bills - w
11
5
0
.688
7
9
0
.438
Jets Jets - e
3
13
0
.188
AFC NorthWLTPCT
9
7
0
.563
8
8
0
.500
6
10
0
.375
4
12
0
.250
AFC SouthWLTPCT
12
4
0
.750
11
5
0
.688
Colts Colts - e
8
8
0
.500
3
13
0
.188
AFC WestWLTPCT
13
3
0
.813
11
5
0
.688
6
10
0
.375
2
14
0
.125

NFL 2025 Scores & Schedule

Scores

DATEMATCHUPSCORE
Sat
9/27
@
20-27
Sat
9/27
@
25-24
Sat
9/27
@
20-37
Sat
9/27
@
40-40
Sun
9/28
@
21-27

Schedule

DATEMATCHUPTIME (ET)
Sun
1/4
@
1:00 PM
Sun
1/4
@
1:00 PM
Sun
1/4
@
1:00 PM
Sun
1/4
@
1:00 PM
Sun
1/4
@
1:00 PM