Rashaad Penny has the most career rushing yards per attempt by a running back with 300+ carries, with 5.6 per attempt.

which running back has the highest yards per carry in nfl history with 300 carries
Interpreted as:
Which running back has the highest yards per carry in NFL history with 300 or more carries?
Penny Mitchell Jackson Charles Cuff Chubb Feathers Brown Caddel Mostert Towler Norwood Morris Mitchell Jones Wilson Motley Sayers Cook Sanders Taylor Trippi Walker Kaufman Harper Herbert Bell 0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5 5.5 5.6 5.4 5.4 5.4 5.4 5.3 5.2 5.2 5.2 5.2 5.2 5.2 5.1 5.1 5.0 5.0 5.0 5.0 5.0 5.0 5.0 4.9 4.9 4.9 4.9 4.9 4.9
NAME YPC ATT GP RUSH YDS RUSH YDS/G RUSH TD REC YDS REC TRG AVG REC YDS/G REC TD
Rashaad Penny Rashaad Penny 5.6 348 45 1,951 43.4 13 227 28 37 8.1 5.0 1
Bobby Mitchell Bobby Mitchell 5.4 423 50 2,297 45.9 16 1,462 128 11.4 29.2 16
Bo Jackson Bo Jackson 5.4 515 38 2,782 73.2 16 352 40 8.8 9.3 2
Jamaal Charles Jamaal Charles 5.4 1,407 119 7,563 63.6 44 2,593 310 441 8.4 21.8 20
Ward Cuff Ward Cuff 5.4 330 90 1,766 19.6 6 1,477 101 14.6 16.4 12
Nick Chubb Nick Chubb 5.3 1,238 77 6,511 84.6 48 1,011 123 162 8.2 13.1 4
Beattie Feathers Beattie Feathers 5.2 378 54 1,980 36.7 16 243 15 16.2 4.5 1
Jim Brown Jim Brown 5.2 2,359 118 12,312 104.3 106 2,499 262 9.5 21.2 20
Ernie Caddel Ernie Caddel 5.2 443 64 2,311 36.1 20 641 54 11.9 10.0 5
Raheem Mostert Raheem Mostert 5.2 674 90 3,513 39.0 32 738 92 122 8.0 8.2 8
Dan Towler Dan Towler 5.2 672 67 3,493 52.1 43 665 62 10.7 9.9 1
Jerious Norwood Jerious Norwood 5.2 399 66 2,056 31.2 7 912 96 134 9.5 13.8 3
Mercury Morris Mercury Morris 5.1 804 99 4,133 41.7 31 543 54 10.1 5.5 1
Brian Mitchell Brian Mitchell 5.1 388 223 1,967 8.8 12 2,336 255 74 9.2 10.5 4
Aaron Jones Aaron Jones 5.0 1,177 97 5,940 61.2 45 2,076 272 364 7.6 21.4 18
Tommy Wilson Tommy Wilson 5.0 508 91 2,553 28.1 18 617 61 10.1 6.8 5
Marion Motley Marion Motley 5.0 339 54 1,696 31.4 5 463 40 11.6 8.6 3
Gale Sayers Gale Sayers 5.0 991 68 4,956 72.9 39 1,307 112 11.7 19.2 9
James Cook James Cook 5.0 326 33 1,629 49.4 4 625 65 86 9.6 18.9 5
Barry Sanders Barry Sanders 5.0 3,062 153 15,269 99.8 99 2,921 352 8.3 19.1 10
Jonathan Taylor Jonathan Taylor 5.0 925 53 4,582 86.5 40 955 123 153 7.8 18.0 4
Charley Trippi Charley Trippi 4.9 537 71 2,655 37.4 15 1,255 125 10.0 17.7 11
Doak Walker Doak Walker 4.9 309 67 1,520 22.7 12 2,539 152 16.7 37.9 21
Napoleon Kaufman Napoleon Kaufman 4.9 978 91 4,792 52.7 12 1,107 127 49 8.7 12.2 5
Bruce Harper Bruce Harper 4.9 374 99 1,829 18.5 8 2,409 220 11.0 24.3 12
StatMuse has season-level data for rush attempts and rushing yards per attempt going back to the 1932 season.

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