The San Francisco 49ers have gained the most all-purpose yards by a team in a game against the Bills, with 621 yards on October 7, 2012.
| TEAM | YDS | DATE | TM | OPP | RESULT | TD | PASS YDS | SCKY | PASS TD | RUSH YDS | RUSH TD | RET YDS | RET TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 621 | 10/7/2012 | vs | W 45-3 | 6 | 310 | 0 | 3 | 311 | 3 | 64 | 0 | ||
| 2 | | 49ers | 598 | 9/13/1992 | vs | L 31-34 | 4 | 449 | 10 | 3 | 159 | 1 | 75 | 0 | ||
| 3 |  | Patriots | 580 | 9/30/2012 | @ | W 52-28 | 7 | 340 | 7 | 3 | 247 | 4 | 34 | 0 | ||
| 4 |  | Seahawks | 559 | 10/30/1977 | vs | W 56-17 | 8 | 333 | 0 | 4 | 226 | 4 | 98 | 0 | ||
| 5 |  | Colts | 555 | 9/23/2001 | vs | W 42-26 | 6 | 421 | 3 | 4 | 137 | 2 | 113 | 0 | ||
| 6 |  | Bengals | 553 | 11/17/1975 | vs | W 33-24 | 4 | 447 | 6 | 2 | 112 | 2 | 130 | 0 | ||
| 7 |  | Texans | 551 | 9/30/1962 | vs | W 41-21 | 6 | 258 | 27 | 3 | 320 | 3 | 83 | 0 | ||
| 8 |  | Chargers | 537 | 12/14/1969 | vs | W 45-6 | 6 | 321 | 26 | 3 | 242 | 3 | 93 | 0 | ||
| 9 |  | Broncos | 532 | 12/21/2008 | vs | L 23-30 | 2 | 359 | 8 | 0 | 181 | 2 | 108 | 0 | ||
| 10 |  | Jets | 532 | 9/15/1985 | vs | W 42-3 | 6 | 257 | 13 | 2 | 288 | 3 | 29 | 1 | ||
| 11 |  | Browns | 532 | 10/29/1978 | vs | W 41-20 | 6 | 234 | 11 | 4 | 309 | 2 | 111 | 0 | ||
| 12 |  | Lions | 521 | 12/15/2024 | vs | L 42-48 | 6 | 494 | 21 | 5 | 48 | 1 | 0 | 0 | ||
| 13 |  | Jets | 513 | 9/22/2013 | vs | W 27-20 | 3 | 331 | 0 | 2 | 182 | 1 | 71 | 0 | ||
| 14 | | Patriots | 510 | 11/18/2007 | @ | W 56-10 | 8 | 383 | 0 | 5 | 127 | 2 | 51 | 1 | ||
| 15 |  | Oilers | 510 | 10/29/1961 | @ | W 28-16 | 4 | 464 | 0 | 4 | 46 | 0 | 62 | 0 | ||
| 16 | | Patriots | 507 | 9/20/2015 | @ | W 40-32 | 4 | 466 | 15 | 3 | 56 | 1 | 41 | 0 | ||
| 17 | | Chiefs | 502 | 10/3/1976 | @ | L 17-50 | 2 | 363 | 22 | 2 | 161 | 0 | 253 | 0 | ||
| 18 | | Patriots | 498 | 11/23/1975 | @ | L 31-45 | 4 | 365 | 5 | 2 | 138 | 2 | 138 | 0 | ||
| 19 |  | Colts | 498 | 11/9/1975 | @ | W 42-35 | 6 | 321 | 22 | 3 | 199 | 3 | 103 | 0 | ||
| 20 | | Patriots | 495 | 9/25/2011 | @ | L 31-34 | 4 | 387 | 0 | 4 | 108 | 0 | 104 | 0 | ||
| 21 |  | Raiders | 495 | 10/6/2002 | @ | W 49-31 | 7 | 357 | 4 | 3 | 142 | 3 | 77 | 1 | ||
| 22 |  | Dolphins | 494 | 12/24/2016 | @ | W 34-31 | 4 | 233 | 0 | 2 | 261 | 2 | 105 | 0 | ||
| 23 | | Patriots | 494 | 12/11/2005 | @ | W 35-7 | 5 | 336 | 1 | 2 | 159 | 2 | 47 | 1 | ||
| 24 | | Raiders | 494 | 12/6/1987 | vs | W 34-21 | 4 | 360 | 10 | 3 | 144 | 1 | 64 | 0 | ||
| 25 | | Jets | 493 | 9/15/2016 | @ | W 37-31 | 4 | 374 | 4 | 1 | 123 | 3 | 54 | 0 | ||
SF
BUF
NE
SEA
IND
CIN
DLT
SD
DEN
NYJ
CLE
DET
NYJ
HOU
BAL
OAK
MIAMore NFL News
Drake Maye found his confidence in big win over Raiders and Patriots suddenly look dangerous again
Saints' recent home woes have left New Orleans desperate to avoid a sixth straight lost season
Texans land Marvin Harrison Jr. after first win, aiming for a quick impact
49ers receiver Deebo Samuel will miss time with hamstring injury
NFL suspends 49ers linebacker Dre Greenlaw 1 game for headbutt
No panic in Nashville: Saleh staying patient as the Titans sink to 0-5
More 49ers Stats
Team Leaders 
PASS
1,196
Purdy
RUSH
286
McCaffrey
REC
326
Evans
Team Rankings
PPG
30.8
3rd
OPP PPG
18.6
3rd
RUSH YDS/G
128.6
8th
PASS YDS/G
239.2
15th
Rams
Cardinals
WAS
ATL
DAL
MIN
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 1 | .700 | |
2 | 3 | 0 | .400 | |
2 | 3 | 0 | .400 | |
1 | 3 | 1 | .300 | |
| NFC North | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| NFC South | W | L | T | PCT |
2 | 2 | 0 | .500 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
1 | 4 | 0 | .200 | |
| NFC West | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
2 | 2 | 0 | .500 | |
1 | 4 | 0 | .200 |
Giants
Eagles
Packers
Bears
Panthers
Buccaneers
Saints| AFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 0 | .750 | |
3 | 2 | 0 | .600 | |
2 | 3 | 0 | .400 | |
0 | 5 | 0 | .000 | |
| AFC North | W | L | T | PCT |
4 | 1 | 0 | .800 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| AFC South | W | L | T | PCT |
4 | 1 | 0 | .800 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
0 | 5 | 0 | .000 | |
| AFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
0 | 5 | 0 | .000 |
Ravens
Steelers
Jaguars
Texans