Since 2019, J.C. Jackson has made the most interceptions, with 21 interceptions.

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who has had the most interceptions in the nfl since 2019
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Who has had the most defensive interceptions in the NFL since 2019?
JacksonHowardSimmonsMathieuDiggsDiggsByardWhiteFitzpatrickGilmoreMcCourtyPoyerSmithPetersBradberryWilliamsMooreJenkinsDesirJacksonOruwariyeHadenHarris21141312111111101099999999888877
NAMEGPINTTKLASTCOMBSCKSCKYINT YDSINT TDFFFRFR TD
J.C. JacksonJ.C. Jackson442197211180.002111130
Xavien HowardXavien Howard321480231030.00940321
Justin SimmonsJustin Simmons4313184612450.001960010
Tyrann MathieuTyrann Mathieu4112150361863.0251902020
Trevon DiggsTrevon Diggs23117916951.001852100
Quandre DiggsQuandre Diggs3711119551740.001701110
Kevin ByardKevin Byard4411181782591.0111451211
Tre'Davious WhiteTre'Davious White4010119371563.020850430
Minkah FitzpatrickMinkah Fitzpatrick4210153672200.002252441
Stephon GilmoreStephon Gilmore3298217990.001542110
Devin McCourtyDevin McCourty449122471690.001331210
Jordan PoyerJordan Poyer429206832894.0291010530
Harrison SmithHarrison Smith409173742473.534560420
Marcus PetersMarcus Peters30986191051.0102273430
James BradberryJames Bradberry419125331581.03380230
Marcus WilliamsMarcus Williams409117531700.001491200
Kenny MooreKenny Moore399177372145.5271591110
Janoris JenkinsJanoris Jenkins398126361620.001371100
Pierre DesirPierre Desir32894231170.00581100
Donte JacksonDonte Jackson398104311350.001560120
Amani OruwariyeAmani Oruwariye36895201150.00230010
Joe HadenJoe Haden387118231410.00581210
Anthony HarrisAnthony Harris4071211012220.00441010
Joe SchobertJoe Schobert4372211313524.531691510
Darius LeonardDarius Leonard3972151313468.047.510011050
StatMuse has season-level data for interceptions going back to the 1940 season.