who has the most rushing yards in week 12

O.J. Simpson has rushed for the most yards in a Week-12 game, with 273 yards versus the Lions on November 25, 1976.

	NAME	RUSH YDS	DATE	TM		OPP	ATT	YPC	RUSH TD	REC YDS	REC	TRG	AVG	REC TD
1	O.J. Simpson	273	11/25/1976	BUF	@	DET	29	9.4	2	0	0			0
2	Saquon Barkley S. Barkley	255	11/24/2024	PHI	@	LAR	26	9.8	2	47	4	4	11.8	0
3	Willie Ellison W. Ellison	247	12/5/1971	LA	vs	NO	26	9.5	1	0	0			0
4	Fred Taylor F. Taylor	234	11/19/2000	JAX	@	PIT	30	7.8	3	14	3	7	4.7	1
5	Josh Jacobs J. Jacobs	229	11/27/2022	LV	@	SEA	33	6.9	2	74	6	7	12.3	0
6	Beanie Wells B. Wells	228	11/27/2011	ARI	@	STL	27	8.4	1	0	0	0		0
7	Priest Holmes P. Holmes	227	11/22/1998	BAL	@	CIN	36	6.3	1	0	0			0
8	Knowshon Moreno K. Moreno	224	11/24/2013	DEN	@	NE	37	6.1	1	6	1	1	6.0	0
9	Tommy Wilson T. Wilson	223	12/16/1956	LA	vs	GB	23	9.7	0	5	1		5.0	0
10	Bo Jackson B. Jackson	221	11/30/1987	RAI	@	SEA	18	12.3	2	14	1		14.0	1
11	Jahmyr Gibbs J. Gibbs	219	11/23/2025	DET	vs	NYG	15	14.6	2	45	11	12	4.1	1
12	Greg Bell G. Bell	206	11/18/1984	BUF	vs	DAL	27	7.6	1	12	2		6.0	1
13	Tony Dorsett T. Dorsett	206	12/4/1977	DAL	vs	PHI	23	9.0	2	24	3		8.0	0
14	Rudi Johnson R. Johnson	202	11/28/2004	CIN	vs	CLE	26	7.8	2	5	1	2	5.0	0
15	Shaun Alexander S. Alexander	201	11/27/2006	SEA	vs	GB	40	5.0	0	0	0	1		0
16	Earl Campbell E. Campbell	199	11/20/1978	HOU	vs	MIA	28	7.1	4	0	0			0
17	Priest Holmes P. Holmes	197	11/24/2002	KC	@	SEA	23	8.6	2	110	7	7	15.7	1
18	Gary Brown G. Brown	194	11/21/1993	HOU	@	CLE	34	5.7	1	28	2		14.0	0
19	Chris Johnson C. Johnson	190	11/27/2011	TEN	vs	TB	23	8.3	0	3	1	2	3.0	0
20	Rick Casares R. Casares	190	12/16/1956	CHB	vs	DET	17	11.2	1	20	1		20.0	0
21	Billy Sims B. Sims	189	11/20/1983	DET	@	GB	36	5.3	0	47	5		9.4	0
22	Bill Paschal B. Paschal	188	12/5/1943	NYG	vs	WAS	24	7.8	2
23	Jamal Lewis J. Lewis	187	11/19/2000	BAL	vs	DAL	28	6.7	0	20	4	4	5.0	0
24	Jim Taylor J. Taylor	186	12/3/1961	GB	vs	NYG	27	6.9	2	18	1		18.0	0
25	LaDainian Tomlinson L. Tomlinson	184	11/27/2005	SD	@	WAS	25	7.4	3	29	6	9	4.8	0

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Results may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.

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Bills - w	12	5	0	.706
Dolphins - e	7	10	0	.412
Jets - e	3	14	0	.176
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