who has the most rushing yards in week 12

O.J. Simpson has the most rushing yards in a Week-12 game, with 273 yards against the Lions on November 25, 1976.

	NAME	RUSH YDS	DATE	TM		OPP	ATT	YPC	RUSH TD	REC YDS	REC	TRG	AVG	REC TD
1	O.J. Simpson	273	11/25/1976	BUF	@	DET	29	9.4	2	0	0			0
2	Saquon Barkley S. Barkley	255	11/24/2024	PHI	@	LAR	26	9.8	2	47	4	4	11.8	0
3	Willie Ellison W. Ellison	247	12/5/1971	LA	vs	NO	26	9.5	1	0	0			0
4	Fred Taylor F. Taylor	234	11/19/2000	JAX	@	PIT	30	7.8	3	14	3	7	4.7	1
5	Josh Jacobs J. Jacobs	229	11/27/2022	LV	@	SEA	33	6.9	2	74	6	7	12.3	0
6	Beanie Wells B. Wells	228	11/27/2011	ARI	@	STL	27	8.4	1	0	0	0		0
7	Priest Holmes P. Holmes	227	11/22/1998	BAL	@	CIN	36	6.3	1	0	0			0
8	Knowshon Moreno K. Moreno	224	11/24/2013	DEN	@	NE	37	6.1	1	6	1	1	6.0	0
9	Tommy Wilson T. Wilson	223	12/16/1956	LA	vs	GB	23	9.7	0	5	1		5.0	0
10	Bo Jackson B. Jackson	221	11/30/1987	RAI	@	SEA	18	12.3	2	14	1		14.0	1
11	Jahmyr Gibbs J. Gibbs	219	11/23/2025	DET	vs	NYG	15	14.6	2	45	11	12	4.1	1
12	Greg Bell G. Bell	206	11/18/1984	BUF	vs	DAL	27	7.6	1	12	2		6.0	1
13	Tony Dorsett T. Dorsett	206	12/4/1977	DAL	vs	PHI	23	9.0	2	24	3		8.0	0
14	Rudi Johnson R. Johnson	202	11/28/2004	CIN	vs	CLE	26	7.8	2	5	1	2	5.0	0
15	Shaun Alexander S. Alexander	201	11/27/2006	SEA	vs	GB	40	5.0	0	0	0	1		0
16	Earl Campbell E. Campbell	199	11/20/1978	HOU	vs	MIA	28	7.1	4	0	0			0
17	Priest Holmes P. Holmes	197	11/24/2002	KC	@	SEA	23	8.6	2	110	7	7	15.7	1
18	Gary Brown G. Brown	194	11/21/1993	HOU	@	CLE	34	5.7	1	28	2		14.0	0
19	Chris Johnson C. Johnson	190	11/27/2011	TEN	vs	TB	23	8.3	0	3	1	2	3.0	0
20	Rick Casares R. Casares	190	12/16/1956	CHB	vs	DET	17	11.2	1	20	1		20.0	0
21	Billy Sims B. Sims	189	11/20/1983	DET	@	GB	36	5.3	0	47	5		9.4	0
22	Bill Paschal B. Paschal	188	12/5/1943	NYG	vs	WAS	24	7.8	2
23	Jamal Lewis J. Lewis	187	11/19/2000	BAL	vs	DAL	28	6.7	0	20	4	4	5.0	0
24	Jim Taylor J. Taylor	186	12/3/1961	GB	vs	NYG	27	6.9	2	18	1		18.0	0
25	LaDainian Tomlinson L. Tomlinson	184	11/27/2005	SD	@	WAS	25	7.4	3	29	6	9	4.8	0

Unlock 2x data

Results may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.

More Bills Stats

Team Leaders

PASS

3,668

Allen

RUSH

1,621

Cook

REC

719

Shakir

Team Rankings

PPG

28.3

4th

OPP PPG

21.5

12th

RUSH YDS/G

159.6

1st

PASS YDS/G

234.2

13th

2025 Division Standings

TEAM	W	L	PCT
Patriots	14	3	.824
Bills	12	5	.706
Dolphins	7	10	.412
Jets	3	14	.176

Last Game

Bills

1 - 1

Final

Broncos

1 - 0

Sat 17 Jan 2026

NFL 2025 Leaders

Pass Yards Leaders

4,707

Stafford

4,564

Goff

4,552

Prescott

Rush Yards Leaders

1,621

Cook

1,595

Henry

1,585

Taylor

Rec Yards Leaders

1,793

Smith-Njigba

1,715

Nacua

1,429

Pickens

Pass TD Leaders

46

Stafford

34

Goff

31

Maye

Rush TD Leaders

18

Taylor

16

Henry

14

Allen

Rec TD Leaders

14

Adams

11

McBride

11

St. Brown

QB Rating Leaders

113.5

Maye

109.2

Stafford

105.5

Goff

Sack Leaders

23.0

Garrett

16.5

Burns

15.0

Hunter

NFL 2025 Rankings

PPG Rankings

30.5

28.8

28.4

28.3

27.9

Opp PPG Rankings

17.2

17.4

18.3

18.8

19.1

19.3

Total Yards Rankings

394.6

391.9

379.4

376.3

373.2

369.5

Rush Yards Rankings

159.6

156.6

144.5

134.7

129.1

128.9

Pass Yards Rankings

278.5

276.9

268.6

262.3

256.1

254.0

Sack Leaders

68.0

57.0

53.0

49.0

48.0

NFL Fantasy 2025

Fantasy RB Rankings

316.3

Taylor

314.6

McCaffrey

291.8

Robinson

Fantasy WR Rankings

246

Nacua

240.9

Smith-Njigba

207

St. Brown

Fantasy TE Rankings

189.9

McBride

125.1

Goedert

122.8

Pitts

Fantasy K Rankings

202

Myers

194

Fairbairn

187.6

Aubrey

NFL 2025 Betting

Best Record ATS

15-5

12-6

14-7

12-6-1

12-7

11-7

Worst Record ATS

5-12

5-12-1

6-11

7-10

NFL 2025 Standings

AFC East	W	L	T	PCT
Patriots - y	14	3	0	.824
Bills - w	12	5	0	.706
Dolphins - e	7	10	0	.412
Jets - e	3	14	0	.176
AFC North	W	L	T	PCT
Steelers - y	10	7	0	.588
Ravens - e	8	9	0	.471
Bengals - e	6	11	0	.353
Browns - e	5	12	0	.294
AFC South	W	L	T	PCT
Jaguars - y	13	4	0	.765
Texans - w	12	5	0	.706
Colts - e	8	9	0	.471
Titans - e	3	14	0	.176
AFC West	W	L	T	PCT
Broncos - z*	14	3	0	.824
Chargers - w	11	6	0	.647
Chiefs - e	6	11	0	.353
Raiders - e	3	14	0	.176

NFC East	W	L	T	PCT
Eagles - y	11	6	0	.647
Cowboys - e	7	9	1	.441
Commanders - e	5	12	0	.294
Giants - e	4	13	0	.235
NFC North	W	L	T	PCT
Bears - y	11	6	0	.647
Packers - w	9	7	1	.559
Vikings - e	9	8	0	.529
Lions - e	9	8	0	.529
NFC South	W	L	T	PCT
Panthers - y	8	9	0	.471
Buccaneers - e	8	9	0	.471
Falcons - e	8	9	0	.471
Saints - e	6	11	0	.353
NFC West	W	L	T	PCT
Seahawks - z*	14	3	0	.824
Rams - w	12	5	0	.706
49ers - w	12	5	0	.706
Cardinals - e	3	14	0	.176