Alvin Kamara and Gale Sayers are tied for the most points in a game, with 36 points.

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who has the most two points in a game
Interpreted as:
Who has the most two points in a regular-season game?
12/25/2020Kamara12/12/1965Sayers10/8/1961Hornung11/21/2021Taylor12/15/2013Charles12/7/2003Portis9/29/2002Alexander10/12/1997Stewart10/14/1990Rice11/22/1981Winslow12/12/1965Hornung12/8/1963Gilchrist12/10/1961Cannon11/26/1961Haynes12/18/1965Cappelletti9/16/1962Hornung10/21/2007Bironas9/18/1960Blanda12/12/2010Feely11/28/2021Fournette11/21/2021Ekeler9/20/2021Jones11/1/2020Cook3636333030303030303030303030282826262524242424
Results may be incomplete. StatMuse has complete game-level data for points going back to the 1960 season.