| NAME | SEASON | TM | GP | YDS | RUSH YDS | ATT | YPC | RUSH YDS/G | RUSH TD | REC YDS | REC | TRG | AVG | REC YDS/G | REC TD | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Chris Johnson | 2009 |  TEN | 16 | 2,509 | 2,006 | 358 | 5.6 | 125.4 | 14 | 503 | 50 | 71 | 10.1 | 31.4 | 2 |
 | Marshall Faulk | 1999 |  STL | 16 | 2,429 | 1,381 | 253 | 5.5 | 86.3 | 7 | 1,048 | 87 | 103 | 12.0 | 65.5 | 5 |
 | Christian McCaffrey | 2019 |  CAR | 16 | 2,392 | 1,387 | 287 | 4.8 | 86.7 | 15 | 1,005 | 116 | 142 | 8.7 | 62.8 | 4 |
| Tiki Barber | 2005 |  NYG | 16 | 2,390 | 1,860 | 357 | 5.2 | 116.3 | 9 | 530 | 54 | 70 | 9.8 | 33.1 | 2 |
 | LaDainian Tomlinson | 2003 |  SD | 16 | 2,370 | 1,645 | 313 | 5.3 | 102.8 | 13 | 725 | 100 | 137 | 7.3 | 45.3 | 4 |
 | Barry Sanders | 1997 |  DET | 16 | 2,358 | 2,053 | 335 | 6.1 | 128.3 | 11 | 305 | 33 | 9.2 | 19.1 | 3 | |
| Steven Jackson | 2006 | STL | 16 | 2,334 | 1,528 | 346 | 4.4 | 95.5 | 13 | 806 | 90 | 110 | 9.0 | 50.4 | 3 |
| LaDainian Tomlinson | 2006 | SD | 16 | 2,323 | 1,815 | 348 | 5.2 | 113.4 | 28 | 508 | 56 | 80 | 9.1 | 31.8 | 3 |
 | Adrian Peterson | 2012 |  MIN | 16 | 2,314 | 2,097 | 348 | 6.0 | 131.1 | 12 | 217 | 40 | 51 | 5.4 | 13.6 | 1 |
| Marcus Allen | 1985 |  RAI | 16 | 2,314 | 1,759 | 380 | 4.6 | 109.9 | 11 | 555 | 67 | 8.3 | 34.7 | 3 | |
| Edgerrin James | 2000 |  IND | 16 | 2,303 | 1,709 | 387 | 4.4 | 106.8 | 13 | 594 | 63 | 87 | 9.4 | 37.1 | 5 |
| Priest Holmes | 2002 |  KC | 14 | 2,287 | 1,615 | 313 | 5.2 | 115.4 | 21 | 672 | 70 | 81 | 9.6 | 48.0 | 3 |
| Jamal Lewis | 2003 |  BAL | 16 | 2,271 | 2,066 | 387 | 5.3 | 129.1 | 14 | 205 | 26 | 38 | 7.9 | 12.8 | 0 |
 | DeMarco Murray | 2014 |  DAL | 16 | 2,261 | 1,845 | 392 | 4.7 | 115.3 | 13 | 416 | 57 | 64 | 7.3 | 26.0 | 0 |
| Ahman Green | 2003 |  GB | 16 | 2,250 | 1,883 | 355 | 5.3 | 117.7 | 15 | 367 | 50 | 60 | 7.3 | 22.9 | 5 |
 | Eric Dickerson | 1984 | RAM | 16 | 2,244 | 2,105 | 379 | 5.6 | 131.6 | 14 | 139 | 21 | 6.6 | 8.7 | 0 | |
 | O.J. Simpson | 1975 |  BUF | 14 | 2,243 | 1,817 | 329 | 5.5 | 129.8 | 16 | 426 | 28 | 15.2 | 30.4 | 7 | |
| James Wilder | 1984 |  TB | 16 | 2,229 | 1,544 | 407 | 3.8 | 96.5 | 13 | 685 | 85 | 8.1 | 42.8 | 0 | |
 | Marshall Faulk | 1998 | IND | 16 | 2,227 | 1,319 | 324 | 4.1 | 82.4 | 6 | 908 | 86 | 10.6 | 56.8 | 4 | |
| Terrell Davis | 1998 |  DEN | 16 | 2,225 | 2,008 | 392 | 5.1 | 125.5 | 21 | 217 | 25 | 8.7 | 13.6 | 2 | |
| Arian Foster | 2010 |  HOU | 16 | 2,220 | 1,616 | 327 | 4.9 | 101.0 | 16 | 604 | 66 | 84 | 9.2 | 37.8 | 2 |
| Ricky Williams | 2002 |  MIA | 16 | 2,216 | 1,853 | 383 | 4.8 | 115.8 | 16 | 363 | 47 | 59 | 7.7 | 22.7 | 1 |
 | Le'Veon Bell | 2014 |  PIT | 16 | 2,215 | 1,361 | 290 | 4.7 | 85.1 | 8 | 854 | 83 | 105 | 10.3 | 53.4 | 3 |
| Eric Dickerson | 1983 | RAM | 16 | 2,212 | 1,808 | 390 | 4.6 | 113.0 | 18 | 404 | 51 | 7.9 | 25.3 | 2 | |
| Larry Johnson | 2006 | KC | 16 | 2,199 | 1,789 | 416 | 4.3 | 111.8 | 17 | 410 | 41 | 67 | 10.0 | 25.6 | 2 |
| Marshall Faulk | |||||||||||||||
 | Frank Gore | |||||||||||||||
| William Andrews | |||||||||||||||
| LaDainian Tomlinson | |||||||||||||||
 | Jonathan Taylor | |||||||||||||||
| Priest Holmes | |||||||||||||||
| Barry Sanders | |||||||||||||||
| Jamal Anderson | |||||||||||||||
| Deuce McAllister | |||||||||||||||
 | Emmitt Smith | |||||||||||||||
| Marshall Faulk | |||||||||||||||
 | LeSean McCoy | |||||||||||||||
 | Derrick Henry | |||||||||||||||
| Edgerrin James | |||||||||||||||
 | Jim Brown | |||||||||||||||
| Tiki Barber | |||||||||||||||
 | Walter Payton | |||||||||||||||
 | David Johnson | |||||||||||||||
| Thurman Thomas | |||||||||||||||
| Priest Holmes | |||||||||||||||
| Garrison Hearst | |||||||||||||||
| Brian Westbrook | |||||||||||||||
| Tiki Barber | |||||||||||||||
 | Todd Gurley | |||||||||||||||
| Larry Johnson |