| TEAM | OPPONENT | WEEK/ROUND | DATE | TIME (ET) | SPREAD | OVER/UNDER | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | New Orleans Saints | +113 | vs |  New York Giants | -133 | WK 5 | Sun, Oct 5, 2025 | 1:00 PM | +2.5 | 41.5 |
| 2 |  | Buffalo Bills | -546 | vs |  New England Patriots | +415 | WK 5 | Sun, Oct 5, 2025 | 8:20 PM | -9.5 | 48.5 |
| 3 | | New Orleans Saints | +140 | vs | New England Patriots | -175 | WK 6 | Sun, Oct 12, 2025 | 4:25 PM | +3.5 | 42.5 |
| 4 | | Buffalo Bills | -238 | @ |  Atlanta Falcons | +190 | WK 6 | Mon, Oct 13, 2025 | 7:15 PM | -5.5 | 48.5 |
| 5 | | New Orleans Saints | +300 | @ |  Chicago Bears | -417 | WK 7 | Sun, Oct 19, 2025 | 1:00 PM | +8.5 | 44.5 |
| 6 | | Buffalo Bills | -333 | @ |  Carolina Panthers | +245 | WK 8 | Sun, Oct 26, 2025 | 1:00 PM | -7.0 | 48.5 |
| 7 | | New Orleans Saints | +190 | vs |  Tampa Bay Buccaneers | -238 | WK 8 | Sun, Oct 26, 2025 | 4:05 PM | +6.5 | 45.5 |
| 8 | | Buffalo Bills | -149 | vs |  Kansas City Chiefs | +120 | WK 9 | Sun, Nov 2, 2025 | 4:25 PM | -2.5 | 48.0 |
| 9 | | New Orleans Saints | +175 | @ | Carolina Panthers | -227 | WK 10 | Sun, Nov 9, 2025 | 1:00 PM | +5.5 | 43.5 |
| 10 | | Buffalo Bills | -238 | @ |  Miami Dolphins | +190 | WK 10 | Sun, Nov 9, 2025 | 1:00 PM | -5.5 | 49.5 |
| 11 | | Buffalo Bills | -227 | @ | New England Patriots | +175 | WK 15 | Sun, Dec 14, 2025 | 1:00 PM | -5.5 | 47.5 |
Betting lines shown represent consensus, closing odds.
More Bills Stats
Team Rankings
PPG
33.3
3rd
OPP PPG
22.5
17th
RUSH YDS/G
163.5
1st
PASS YDS/G
249.0
7th
Bills 
Jets 
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 4 | 0 | 0 | 1.000 |
 Commanders | 2 | 2 | 0 | .500 |
| NFC North | W | L | T | PCT |
 Lions | 3 | 1 | 0 | .750 |
 Packers | 2 | 1 | 0 | .667 |
| NFC South | W | L | T | PCT |
| Buccaneers | 3 | 1 | 0 | .750 |
| Falcons | 2 | 2 | 0 | .500 |
| NFC West | W | L | T | PCT |
 49ers | 3 | 1 | 0 | .750 |
 Seahawks | 3 | 1 | 0 | .750 |
Steelers 
Bengals 
Colts 
Jaguars 
Chargers 
Raiders 
DAL 
DEN 
LAR 
MIN 
CLE 
