The San Francisco 49ers have a 70-63 record against the spread as favorites against the AFC all-time.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 11/15/1981 | 0-1 | vs | L 12-15 | -3 | -6 (N) | 43 | -16 (U) | 0 | 21 | 305 | 267 | ||||||
| 2 | | 49ers | 12/13/1981 | 1-0 | vs | W 28-6 | -7 | +15 (Y) | 39 | -5 (U) | 4 | 22 | 414 | 186 | ||||||
| 3 | | 49ers | 1/24/1982 | 1-0 | @ | W 26-21 | -1 | +4 (Y) | 48 | -1 (U) | 2 | 20 | 275 | 356 | ||||||
| 4 | | 49ers | 9/12/1982 | 0-1 | vs | L 17-23 | -6 | -12 (N) | 38 | +2 (O) | 2 | 18 | 252 | 255 | ||||||
| 5 | | 49ers | 12/11/1982 | 0-1 | vs | L 37-41 | -2 | -6 (N) | 47 | +31 (O) | 5 | 29 | 465 | 538 | ||||||
| 6 | | 49ers | 12/26/1982 | 1-0 | @ | W 26-13 | -3 | +10 (Y) | 41 | -2 (U) | 2 | 23 | 370 | 275 | ||||||
| 7 | | 49ers | 10/2/1983 | 1-0 | @ | W 33-13 | -3 | +17 (Y) | 49.5 | -3.5 (U) | 3 | 29 | 426 | 295 | ||||||
| 8 | | 49ers | 10/30/1983 | 0-1 | vs | L 13-27 | -6 | -20 (N) | 47.5 | -7.5 (U) | 1 | 17 | 312 | 364 | ||||||
| 9 | | 49ers | 11/6/1983 | 0-1 | vs | L 17-20 | -2 | -5 (N) | 45 | -8 (U) | 2 | 20 | 394 | 316 | ||||||
| 10 | | 49ers | 12/11/1983 | 1-0 | @ | W 23-10 | -1.5 | +11.5 (Y) | 39 | -6 (U) | 2 | 19 | 310 | 303 | ||||||
| 11 | | 49ers | 10/14/1984 | 0-1 | vs | L 17-20 | -8 | -11 (N) | 42 | -5 (U) | 2 | 22 | 358 | 324 | ||||||
| 12 | | 49ers | 10/21/1984 | 1-0 | @ | W 34-21 | -11 | +2 (Y) | 42 | +13 (O) | 4 | 25 | 517 | 432 | ||||||
| 13 | | 49ers | 11/4/1984 | 0-1 | vs | W 23-17 | -10.5 | -4.5 (N) | 43 | -3 (U) | 2 | 26 | 385 | 346 | ||||||
| 14 | | 49ers | 11/11/1984 | 1-0 | @ | W 41-7 | -6 | +28 (Y) | 35 | +13 (O) | 5 | 23 | 468 | 251 | ||||||
| 15 | | 49ers | 1/20/1985 | 1-0 | vs | W 38-16 | -3.5 | +18.5 (Y) | 53.5 | +0.5 (O) | 5 | 31 | 537 | 314 | ||||||
| 16 | | 49ers | 9/22/1985 | 1-0 | @ | W 34-10 | -2.5 | +21.5 (Y) | 44 | 0 (P) | 4 | 17 | 352 | 280 | ||||||
| 17 | | 49ers | 11/11/1985 | 0-1 | @ | L 16-17 | -3 | -4 (N) | 39 | -6 (U) | 1 | 16 | 341 | 336 | ||||||
| 18 | | 49ers | 11/17/1985 | 1-0 | vs | W 31-3 | -12.5 | +15.5 (Y) | 44 | -10 (U) | 4 | 24 | 417 | 200 | ||||||
| 19 | | 49ers | 11/25/1985 | 1-0 | vs | W 19-6 | -7 | +6 (Y) | 42 | -17 (U) | 2 | 21 | 376 | 252 | ||||||
| 20 | | 49ers | 10/5/1986 | 1-0 | vs | W 35-14 | -17 | +4 (Y) | 39.5 | +9.5 (O) | 5 | 16 | 358 | 323 | ||||||
| 21 | | 49ers | 12/7/1986 | 1-0 | vs | W 24-10 | -6 | +8 (Y) | 44 | -10 (U) | 3 | 27 | 432 | 199 | ||||||
| 22 | | 49ers | 12/14/1986 | 1-0 | @ | W 29-24 | -2.5 | +2.5 (Y) | 41 | +12 (O) | 3 | 23 | 400 | 267 | ||||||
| 23 | | 49ers | 9/13/1987 | 0-1 | @ | L 17-30 | -6 | -19 (N) | 40 | +7 (O) | 2 | 24 | 356 | 266 | ||||||
| 24 | | 49ers | 11/8/1987 | 0-1 | vs | W 27-20 | -9.5 | -2.5 (N) | 45 | +2 (O) | 3 | 33 | 443 | 269 | ||||||
| 25 | | 49ers | 11/29/1987 | 1-0 | vs | W 38-24 | -3 | +11 (Y) | 46 | +16 (O) | 5 | 23 | 455 | 360 | ||||||
| Average | 0.4 | 3.0 | 21.3 | 374.4 | 300.9 | |||||||||||||||
| Total | 70-63 | 395 | 2,835 | 49,795 | 40,018 | |||||||||||||||
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More 49ers Stats
Team Leaders 
PASS
1,196
Purdy
RUSH
286
McCaffrey
REC
326
Evans
Team Rankings
PPG
30.8
3rd
OPP PPG
18.6
3rd
RUSH YDS/G
128.6
8th
PASS YDS/G
239.2
15th
Rams
Cardinals
WAS
ATL
DAL
MIN
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 1 | .700 | |
2 | 3 | 0 | .400 | |
2 | 3 | 0 | .400 | |
1 | 3 | 1 | .300 | |
| NFC North | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| NFC South | W | L | T | PCT |
2 | 2 | 0 | .500 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
1 | 4 | 0 | .200 | |
| NFC West | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 |
Giants
Eagles
Packers
Lions
Bears
Panthers
Buccaneers
Saints| AFC East | W | L | T | PCT |
|---|---|---|---|---|
4 | 1 | 0 | .800 | |
3 | 2 | 0 | .600 | |
2 | 3 | 0 | .400 | |
0 | 5 | 0 | .000 | |
| AFC North | W | L | T | PCT |
4 | 1 | 0 | .800 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| AFC South | W | L | T | PCT |
4 | 1 | 0 | .800 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
0 | 5 | 0 | .000 | |
| AFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
0 | 5 | 0 | .000 |
Ravens
Jaguars
Texans
Titans