The San Francisco 49ers have a record of 11-1 against the spread against the NFC East since January 22, 2021.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/19/2021 | 1-0 | -150 | @ | +127 | W 17-11 | -3 | +3 (Y) | 49 | -21 (U) | 2 | 23 | 306 | 328 | 42.9 | 100.0 | ||
| 2 | | 49ers | 1/16/2022 | 1-0 | +153 | @ | -181 | W 23-17 | +3.5 | +9.5 (Y) | 51 | -11 (U) | 2 | 21 | 341 | 307 | 46.2 | |||
| 3 | | 49ers | 12/24/2022 | 1-0 | -299 | vs | +240 | W 37-20 | -6.5 | +10.5 (Y) | 37 | +20 (O) | 4 | 14 | 371 | 349 | 36.4 | 50.0 | ||
| 4 | | 49ers | 1/22/2023 | 1-0 | -194 | vs | +162 | W 19-12 | -3.5 | +3.5 (Y) | 46.5 | -15.5 (U) | 1 | 21 | 312 | 282 | 50.0 | |||
| 5 | | 49ers | 1/29/2023 | 0-1 | +131 | @ | -155 | L 7-31 | +3 | -21 (N) | 44.5 | -6.5 (U) | 1 | 11 | 164 | 269 | 25.0 | 0.0 | ||
| 6 | | 49ers | 9/21/2023 | 1-0 | -573 | vs | +426 | W 30-12 | -10.5 | +7.5 (Y) | 43.5 | -1.5 (U) | 3 | 26 | 441 | 150 | 56.3 | |||
| 7 | | 49ers | 10/8/2023 | 1-0 | -182 | vs | +154 | W 42-10 | -3.5 | +28.5 (Y) | 45.5 | +6.5 (O) | 6 | 25 | 421 | 197 | 54.5 | 0.0 | ||
| 8 | | 49ers | 12/3/2023 | 1-0 | -158 | @ | +134 | W 42-19 | -3 | +20 (Y) | 46.5 | +14.5 (O) | 6 | 24 | 456 | 333 | 72.7 | 100.0 | ||
| 9 | | 49ers | 12/31/2023 | 1-0 | -967 | @ | +633 | W 27-10 | -14 | +3 (Y) | 48.5 | -11.5 (U) | 3 | 28 | 408 | 225 | 44.4 | 0.0 | ||
| 10 | | 49ers | 10/27/2024 | 1-0 | -249 | vs | +203 | W 30-24 | -5.5 | +0.5 (Y) | 47.5 | +6.5 (O) | 3 | 19 | 469 | 292 | 50.0 | 0.0 | ||
| 11 | | 49ers | 11/2/2025 | 1-0 | -145 | @ | +122 | W 34-24 | -2.5 | +7.5 (Y) | 47.5 | +10.5 (O) | 4 | 25 | 380 | 296 | 54.5 | 100.0 | ||
| 12 | | 49ers | 1/11/2026 | 1-0 | +208 | @ | -262 | W 23-19 | +5.5 | +9.5 (Y) | 44.5 | -2.5 (U) | 3 | 20 | 361 | 307 | 54.5 | |||
| Average | 7.6 | 3.2 | 21.4 | 369.2 | 277.9 | 49.7 | 5.0 | |||||||||||||
| Total | 11-1 | 38 | 257 | 4,430 | 3,335 | 49.7 | 40.0 |
StatMuse has team, game-level data for spread records going back to the 1979 season.
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| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
