The San Francisco 49ers are 10-12 against the spread as underdogs since January 22, 2021.

	TEAM	DATE	ATS	TM			OPP		RESULT	SPREAD	ATS DIFF	O/U	O/U DIFF	TD	1DWN	OFF	OPP OFF	3DWN%	4DWN%
1	49ers	10/10/2021	0-1	SF	+208	@	ARI	-257	L 10-17	+5.5	-1.5 (N)	48.5	-21.5 (U)	1	19	338	304	27.3	20.0
2	49ers	11/15/2021	1-0	SF	+154	vs	LAR	-184	W 31-10	+3.5	+24.5 (Y)	50	-9 (U)	4	20	335	278	57.1	50.0
3	49ers	1/9/2022	1-0	SF	+151	@	LAR	-178	W 27-24	+3.5	+6.5 (Y)	46.5	+4.5 (O)	3	23	449	265	64.3
4	49ers	1/16/2022	1-0	SF	+153	@	DAL	-181	W 23-17	+3.5	+9.5 (Y)	51	-11 (U)	2	21	341	307	46.2
5	49ers	1/22/2022	1-0	SF	+208	@	GB	-254	W 13-10	+5.5	+8.5 (Y)	47	-24 (U)	1	12	212	263	36.4	0.0
6	49ers	1/30/2022	1-0	SF	+155	@	LAR	-183	L 17-20	+3.5	+0.5 (Y)	45.5	-8.5 (U)	2	16	282	396	33.3
7	49ers	10/23/2022	0-1	SF	-103	vs	KC	-118	L 23-44	+1	-20 (N)	49	+18 (O)	2	25	444	529	57.1
8	49ers	10/30/2022	1-0	SF	-107	@	LAR	-113	W 31-14	-1.5	+15.5 (Y)	42	+3 (O)	4	22	368	223	55.6
9	49ers	1/29/2023	0-1	SF	+131	@	PHI	-155	L 7-31	+3	-21 (N)	44.5	-6.5 (U)	1	11	164	269	25.0	0.0
10	49ers	11/24/2024	0-1	SF	+237	@	GB	-292	L 10-38	+6	-22 (N)	45	+3 (O)	1	11	241	325	30.0	0.0
11	49ers	12/1/2024	0-1	SF	+265	@	BUF	-330	L 10-35	+6.5	-18.5 (N)	45.5	-0.5 (U)	1	15	239	372	30.0	100.0
12	49ers	12/30/2024	0-1	SF	+183	vs	DET	-223	L 34-40	+3.5	-2.5 (N)	50.5	+23.5 (O)	5	29	475	439	62.5	100.0
13	49ers	1/5/2025	0-1	SF	+188	@	ARI	-229	L 24-47	+4.5	-18.5 (N)	43	+28 (O)	3	26	436	393	38.5	50.0
14	49ers	10/2/2025	1-0	SF	+344	@	LAR	-444	W 26-23	+8.5	+11.5 (Y)	43.5	+5.5 (O)	2	27	407	456	38.9	100.0
15	49ers	10/12/2025	0-1	SF	+158	@	TB	-189	L 19-30	+3.5	-7.5 (N)	47	+2 (O)	1	17	363	352	43.8	0.0
16	49ers	10/19/2025	1-0	SF	-106	vs	ATL	-112	W 20-10	-1.5	+8.5 (Y)	46.5	-16.5 (U)	2	23	324	292	60.0
17	49ers	10/26/2025	0-1	SF	+135	@	HOU	-159	L 15-26	+3	-8 (N)	42	-1 (U)	2	12	223	475	33.3	0.0
18	49ers	11/9/2025	0-1	SF	+210	vs	LAR	-254	L 26-42	+5.5	-10.5 (N)	49.5	+18.5 (O)	4	24	393	401	37.5	33.3
19	49ers	1/3/2026	0-1	SF	+131	vs	SEA	-156	L 3-13	+2.5	-7.5 (N)	48.5	-32.5 (U)	0	9	173	361	22.2	0.0
20	49ers	1/11/2026	1-0	SF	+208	@	PHI	-262	W 23-19	+5.5	+9.5 (Y)	44.5	-2.5 (U)	3	20	361	307	54.5
21	49ers	1/17/2026	0-1	SF	+245	@	SEA	-304	L 6-41	+7	-28 (N)	44.5	+2.5 (O)	0	15	236	281	50.0	0.0
22	49ers	9/10/2026	1-0	SF	+172	@	LAR	-207	W 27-7	+3.5	+23.5 (Y)	47.5	-13.5 (U)	3	23	379	290	58.3
	Average		2.1											2.1	19.1	326.5	344.5	44.9	0.0
	Total		10-12											47	420	7,183	7,578	44.9	30.0

StatMuse has team, game-level data for spread records going back to the 1979 season.

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More 49ers Stats

Team Leaders

PASS

789

Purdy

RUSH

166

McCaffrey

REC

174

Kittle

Team Rankings

PPG

32.7

2nd

OPP PPG

16.7

3rd

RUSH YDS/G

136.3

6th

PASS YDS/G

263.0

9th

2026 Division Standings

TEAM	W	L	PCT
49ers	3	0	1.000
Seahawks	2	1	.667
Cardinals	1	2	.333
Rams	1	2	.333

Schedule

DATE	MATCHUP			TIME (ET)
Sun 10/4	DEN	@	SF	4:25 PM
Sun 10/11	SF	@	SEA	4:25 PM
Mon 10/19	WAS	@	SF	8:15 PM
Sun 10/25	SF	@	ATL	1:00 PM
Sun 11/8	LV	@	SF	4:05 PM

Last Game

Cardinals

1 - 2

Final

49ers

3 - 0

Sun 27 Sep 2026

NFL 2026 Leaders

Pass Yards Leaders

939

Young

917

Shough

872

Stafford

Rush Yards Leaders

360

Walker

349

Robinson

346

Cook

Rec Yards Leaders

405

Smith-Njigba

375

Olave

358

Adams

Pass TD Leaders

9

Purdy

9

Cousins

8

Shough

Rush TD Leaders

6

Allen

6

Henry

4

Gibbs

Rec TD Leaders

6

Smith-Njigba

5

St. Brown

4

Watson

QB Rating Leaders

133.1

Purdy

127.3

Lock

116.1

Goff

Sack Leaders

6.0

Rousseau

4.0

Anderson

4.0

Graham

NFL 2026 Rankings

PPG Rankings

33.7

32.7

31.0

30.7

29.7

Opp PPG Rankings

12.0

13.7

16.7

17.0

Total Yards Rankings

417.7

416.3

408.0

401.7

399.3

398.7

Rush Yards Rankings

184.3

173.0

167.3

155.0

153.3

136.3

Pass Yards Rankings

313.0

305.7

295.0

281.3

276.0

270.7

Sack Leaders

14.0

12.0

11.0

10.0

9.0

NFL Fantasy 2026

Fantasy RB Rankings

80.3

Gibbs

69.9

Henry

68.2

Walker

Fantasy WR Rankings

77.1

Smith-Njigba

52.8

St. Brown

52.4

Watson

Fantasy TE Rankings

35.4

Kittle

35.1

Kelce

33.3

Johnson

Fantasy K Rankings

42

McPherson

39

McLaughlin

38

Shrader

NFL 2026 Betting

Best Record ATS

3-0

2-0-1

2-1

Worst Record ATS

0-3

NFL 2026 Standings

NFC East	W	L	T	PCT
Eagles	2	1	0	.667
Giants	2	1	0	.667
Cowboys	1	2	0	.333
Commanders	1	2	0	.333
NFC North	W	L	T	PCT
Vikings	3	0	0	1.000
Lions	2	1	0	.667
Bears	2	1	0	.667
Packers	1	2	0	.333
NFC South	W	L	T	PCT
Panthers	1	2	0	.333
Saints	1	2	0	.333
Falcons	1	2	0	.333
Buccaneers	0	3	0	.000
NFC West	W	L	T	PCT
49ers	3	0	0	1.000
Seahawks	2	1	0	.667
Rams	1	2	0	.333
Cardinals	1	2	0	.333

AFC East	W	L	T	PCT
Bills	3	0	0	1.000
Jets	1	2	0	.333
Patriots	1	2	0	.333
Dolphins	0	3	0	.000
AFC North	W	L	T	PCT
Steelers	2	1	0	.667
Ravens	2	1	0	.667
Browns	2	1	0	.667
Bengals	2	1	0	.667
AFC South	W	L	T	PCT
Jaguars	2	1	0	.667
Colts	1	2	0	.333
Titans	0	3	0	.000
Texans	0	3	0	.000
AFC West	W	L	T	PCT
Chiefs	3	0	0	1.000
Raiders	3	0	0	1.000
Broncos	2	1	0	.667
Chargers	0	3	0	.000