49ers ats since 1/22/21 vs nfc

The San Francisco 49ers have a record of 41-29 against the spread against the NFC since January 22, 2021.

		TEAM	DATE	ATS	TM			OPP		RESULT	SPREAD	ATS DIFF	O/U	O/U DIFF	TD	1DWN	OFF	OPP OFF	3DWN%	4DWN%
1		49ers	9/12/2021	1-0	SF	-371	@	DET	+285	W 41-33	-7.5	+0.5 (Y)	45	+29 (O)	5	21	442	430	33.3
2		49ers	9/19/2021	1-0	SF	-150	@	PHI	+127	W 17-11	-3	+3 (Y)	49	-21 (U)	2	23	306	328	42.9	100.0
3		49ers	9/26/2021	0-1	SF	-174	vs	GB	+148	L 28-30	-3	-5 (N)	50.5	+7.5 (O)	4	26	298	353	63.6
4		49ers	10/3/2021	0-1	SF	-137	vs	SEA	+115	L 21-28	-2.5	-9.5 (N)	52	-3 (U)	3	23	457	234	14.3	75.0
5		49ers	10/10/2021	0-1	SF	+208	@	ARI	-257	L 10-17	+5.5	-1.5 (N)	48.5	-21.5 (U)	1	19	338	304	27.3	20.0
6		49ers	10/31/2021	1-0	SF	-210	@	CHI	+172	W 33-22	-4.5	+6.5 (Y)	40	+15 (O)	3	21	467	324	40.0	100.0
7		49ers	11/7/2021	0-1	SF	-247	vs	ARI	+199	L 17-31	-5.5	-19.5 (N)	44.5	+3.5 (O)	2	22	337	437	40.0
8		49ers	11/15/2021	1-0	SF	+154	vs	LAR	-184	W 31-10	+3.5	+24.5 (Y)	50	-9 (U)	4	20	335	278	57.1	50.0
9		49ers	11/28/2021	1-0	SF	-200	vs	MIN	+168	W 34-26	-4	+4 (Y)	49	+11 (O)	4	23	423	323	41.7
10		49ers	12/5/2021	0-1	SF	-143	@	SEA	+122	L 23-30	-2.5	-9.5 (N)	44.5	+8.5 (O)	3	17	365	327	30.0	50.0
11		49ers	12/19/2021	1-0	SF	-408	vs	ATL	+311	W 31-13	-9	+9 (Y)	47.5	-3.5 (U)	4	23	397	275	54.5
12		49ers	1/9/2022	1-0	SF	+151	@	LAR	-178	W 27-24	+3.5	+6.5 (Y)	46.5	+4.5 (O)	3	23	449	265	64.3
13		49ers	1/16/2022	1-0	SF	+153	@	DAL	-181	W 23-17	+3.5	+9.5 (Y)	51	-11 (U)	2	21	341	307	46.2
14		49ers	1/22/2022	1-0	SF	+208	@	GB	-254	W 13-10	+5.5	+8.5 (Y)	47	-24 (U)	1	12	212	263	36.4	0.0
15		49ers	1/30/2022	1-0	SF	+155	@	LAR	-183	L 17-20	+3.5	+0.5 (Y)	45.5	-8.5 (U)	2	16	282	396	33.3
16		49ers	9/11/2022	0-1	SF	-285	@	CHI	+230	L 10-19	-6.5	-15.5 (N)	38	-9 (U)	1	17	331	204	47.1	0.0
17		49ers	9/18/2022	1-0	SF	-394	vs	SEA	+306	W 27-7	-8.5	+11.5 (Y)	39.5	-5.5 (U)	3	25	373	216	40.0	66.7
18		49ers	10/3/2022	1-0	SF	-125	vs	LAR	+105	W 24-9	-2	+13 (Y)	42	-9 (U)	3	13	327	257	41.7	0.0
19		49ers	10/9/2022	1-0	SF	-261	@	CAR	+211	W 37-15	-6	+16 (Y)	39.5	+12.5 (O)	5	22	397	308	58.3
20		49ers	10/16/2022	0-1	SF	-192	@	ATL	+161	L 14-28	-3.5	-17.5 (N)	46	-4 (U)	2	21	346	289	37.5	0.0
21		49ers	10/30/2022	1-0	SF	-107	@	LAR	-113	W 31-14	-1.5	+15.5 (Y)	42	+3 (O)	4	22	368	223	55.6
22		49ers	11/21/2022	1-0	SF	-442	@	ARI	+341	W 38-10	-9.5	+18.5 (Y)	43	+5 (O)	5	21	387	314	54.5
23		49ers	11/27/2022	1-0	SF	-426	vs	NO	+325	W 13-0	-8.5	+4.5 (Y)	43.5	-30.5 (U)	1	21	317	260	38.5	50.0
24		49ers	12/11/2022	1-0	SF	-182	vs	TB	+152	W 35-7	-3.5	+24.5 (Y)	38.5	+3.5 (O)	5	24	404	322	44.4	50.0
25		49ers	12/15/2022	1-0	SF	-181	@	SEA	+152	W 21-13	-3	+5 (Y)	42.5	-8.5 (U)	3	15	381	277	46.2
		Average		0.8											3.0	21.2	369.0	313.4	46.1	1.1
		Total		41-29											212	1,485	25,832	21,936	46.1	45.9

StatMuse has team, game-level data for spread records going back to the 1979 season.

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2025 Division Standings

TEAM	W	L	T	PCT
Seahawks	14	3	0	.824
Rams	12	5	0	.706
49ers	12	5	0	.706
Cardinals	3	14	0	.176

1 - 1

6

Final

41

SEA

1 - 0

Sat 17 Jan 2026

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Pass Yards Leaders

4,707

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4,564

Goff

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4,552

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Rush Yards Leaders

1,621

Cook

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1,595

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1,585

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Rec Yards Leaders

1,793

Smith-Njigba

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1,715

Nacua

Puka Nacua

1,429

Pickens

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Pass TD Leaders

46

Stafford

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34

Goff

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31

Maye

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Rush TD Leaders

18

Taylor

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16

Henry

Derrick Henry

14

Allen

Josh Allen

14

Adams

Davante Adams

11

McBride

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11

St. Brown

Amon-Ra St. Brown

QB Rating Leaders

113.5

Maye

Drake Maye

109.2

Stafford

Matthew Stafford

105.5

Goff

Jared Goff

23.0

Garrett

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16.5

Burns

Brian Burns

15.0

Hunter

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30.5

28.8

28.4

28.3

28.3

27.9

Opp PPG Rankings

17.2

17.4

18.3

18.8

19.1

19.3

Total Yards Rankings

394.6

391.9

379.4

376.3

373.2

369.5

Rush Yards Rankings

159.6

156.6

144.5

134.7

129.1

128.9

Pass Yards Rankings

278.5

276.9

268.6

262.3

256.1

254.0

68.0

57.0

53.0

49.0

49.0

48.0

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Fantasy RB Rankings

316.3

Taylor

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314.6

McCaffrey

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291.8

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Fantasy WR Rankings

246

Nacua

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240.9

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Fantasy TE Rankings

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122.8

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Fantasy K Rankings

202

Myers

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194

Fairbairn

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187.6

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NFL 2025 Betting

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15-5

12-6

14-7

12-6-1

12-7

11-7

Worst Record ATS

5-12

5-12-1

6-11

6-11

6-11

7-10

NFL 2025 Standings

AFC East	W	L	T	PCT
Patriots - y	14	3	0	.824
Bills - w	12	5	0	.706
Dolphins - e	7	10	0	.412
Jets - e	3	14	0	.176
AFC North	W	L	T	PCT
Steelers - y	10	7	0	.588
Ravens - e	8	9	0	.471
Bengals - e	6	11	0	.353
Browns - e	5	12	0	.294
AFC South	W	L	T	PCT
Jaguars - y	13	4	0	.765
Texans - w	12	5	0	.706
Colts - e	8	9	0	.471
Titans - e	3	14	0	.176
AFC West	W	L	T	PCT
Broncos - z*	14	3	0	.824
Chargers - w	11	6	0	.647
Chiefs - e	6	11	0	.353
Raiders - e	3	14	0	.176

NFC East	W	L	T	PCT
Eagles - y	11	6	0	.647
Cowboys - e	7	9	1	.441
Commanders - e	5	12	0	.294
Giants - e	4	13	0	.235
NFC North	W	L	T	PCT
Bears - y	11	6	0	.647
Packers - w	9	7	1	.559
Vikings - e	9	8	0	.529
Lions - e	9	8	0	.529
NFC South	W	L	T	PCT
Panthers - y	8	9	0	.471
Buccaneers - e	8	9	0	.471
Falcons - e	8	9	0	.471
Saints - e	6	11	0	.353
NFC West	W	L	T	PCT
Seahawks - z*	14	3	0	.824
Rams - w	12	5	0	.706
49ers - w	12	5	0	.706
Cardinals - e	3	14	0	.176