The San Francisco 49ers have a record of 10-8 against the spread as underdogs in the regular season and playoffs against the NFC since December 28, 2021.
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| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 1/9/2022 | 1-0 | +151 | @ | -178 | W 27-24 | +3.5 | +6.5 (Y) | 46.5 | +4.5 (O) | 3 | 23 | 449 | 265 | 64.3 | |||
| 2 | | 49ers | 1/16/2022 | 1-0 | +153 | @ | -181 | W 23-17 | +3.5 | +9.5 (Y) | 51 | -11 (U) | 2 | 21 | 341 | 307 | 46.2 | |||
| 3 | | 49ers | 1/22/2022 | 1-0 | +208 | @ | -254 | W 13-10 | +5.5 | +8.5 (Y) | 47 | -24 (U) | 1 | 12 | 212 | 263 | 36.4 | 0.0 | ||
| 4 | | 49ers | 1/30/2022 | 1-0 | +155 | @ | -183 | L 17-20 | +3.5 | +0.5 (Y) | 45.5 | -8.5 (U) | 2 | 16 | 282 | 396 | 33.3 | |||
| 5 | | 49ers | 10/30/2022 | 1-0 | -107 | @ | -113 | W 31-14 | -1.5 | +15.5 (Y) | 42 | +3 (O) | 4 | 22 | 368 | 223 | 55.6 | |||
| 6 | | 49ers | 1/29/2023 | 0-1 | +131 | @ | -155 | L 7-31 | +3 | -21 (N) | 44.5 | -6.5 (U) | 1 | 11 | 164 | 269 | 25.0 | 0.0 | ||
| 7 | | 49ers | 11/24/2024 | 0-1 | +237 | @ | -292 | L 10-38 | +6 | -22 (N) | 45 | +3 (O) | 1 | 11 | 241 | 325 | 30.0 | 0.0 | ||
| 8 | | 49ers | 12/30/2024 | 0-1 | +183 | vs | -223 | L 34-40 | +3.5 | -2.5 (N) | 50.5 | +23.5 (O) | 5 | 29 | 475 | 439 | 62.5 | 100.0 | ||
| 9 | | 49ers | 1/5/2025 | 0-1 | +188 | @ | -229 | L 24-47 | +4.5 | -18.5 (N) | 43 | +28 (O) | 3 | 26 | 436 | 393 | 38.5 | 50.0 | ||
| 10 | | 49ers | 10/2/2025 | 1-0 | +344 | @ | -444 | W 26-23 | +8.5 | +11.5 (Y) | 43.5 | +5.5 (O) | 2 | 27 | 407 | 456 | 38.9 | 100.0 | ||
| 11 | | 49ers | 10/12/2025 | 0-1 | +158 | @ | -189 | L 19-30 | +3.5 | -7.5 (N) | 47 | +2 (O) | 1 | 17 | 363 | 352 | 43.8 | 0.0 | ||
| 12 | | 49ers | 10/19/2025 | 1-0 | -106 | vs | -112 | W 20-10 | -1.5 | +8.5 (Y) | 46.5 | -16.5 (U) | 2 | 23 | 324 | 292 | 60.0 | |||
| 13 | | 49ers | 11/9/2025 | 0-1 | +210 | vs | -254 | L 26-42 | +5.5 | -10.5 (N) | 49.5 | +18.5 (O) | 4 | 24 | 393 | 401 | 37.5 | 33.3 | ||
| 14 | | 49ers | 1/3/2026 | 0-1 | +131 | vs | -156 | L 3-13 | +2.5 | -7.5 (N) | 48.5 | -32.5 (U) | 0 | 9 | 173 | 361 | 22.2 | 0.0 | ||
| 15 | | 49ers | 1/11/2026 | 1-0 | +208 | @ | -262 | W 23-19 | +5.5 | +9.5 (Y) | 44.5 | -2.5 (U) | 3 | 20 | 361 | 307 | 54.5 | |||
| 16 | | 49ers | 1/17/2026 | 0-1 | +245 | @ | -304 | L 6-41 | +7 | -28 (N) | 44.5 | +2.5 (O) | 0 | 15 | 236 | 281 | 50.0 | 0.0 | ||
| 17 | | 49ers | 9/10/2026 | 1-0 | +172 | @ | -207 | W 27-7 | +3.5 | +23.5 (Y) | 47.5 | -13.5 (U) | 3 | 23 | 379 | 290 | 58.3 | |||
| 18 | | 49ers | 10/11/2026 | 1-0 | +135 | @ | -164 | W 32-29 | +3 | +6 (Y) | 46.5 | +14.5 (O) | 4 | 14 | 269 | 251 | 33.3 | |||
| Average | 3.1 | 2.3 | 19.1 | 326.3 | 326.2 | 44.7 | 0.0 | |||||||||||||
| Total | 10-8 | 41 | 343 | 5,873 | 5,871 | 44.7 | 28.6 |
SF
LAR
DAL
GB
PHI
DET
ARI
TB
ATL
SEAMore NFL News
Josh Jacobs says Packers running backs must help out their injury-riddled offensive line
Raiders activate Dont'e Thornton Jr. off injured reserve and waive Jonah Laulu
Bears defensive end Montez Sweat returns from PED suspension and apologizes to teammates
The 49ers bring back DeForest Buckner in trade with the Colts
Cowboys had that run-first look in beating the Eagles, and owner Jerry Jones liked what he saw
Colts send All-Pro guard Quenton Nelson to Seahawks, DeForest Buckner to 49ers for draft picks
More 49ers Stats
Team Leaders 
PASS
1,748
Purdy
RUSH
389
McCaffrey
REC
425
Kittle
Team Rankings
PPG
28.1
3rd
OPP PPG
19.9
6th
RUSH YDS/G
127.4
8th
PASS YDS/G
249.7
12th
LV
MIN
NYG
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
4 | 2 | 1 | .643 | |
3 | 4 | 0 | .429 | |
2 | 5 | 0 | .286 | |
1 | 4 | 1 | .250 | |
| NFC North | W | L | T | PCT |
6 | 0 | 0 | 1.000 | |
5 | 2 | 0 | .714 | |
4 | 2 | 0 | .667 | |
4 | 3 | 0 | .571 | |
| NFC South | W | L | T | PCT |
3 | 3 | 0 | .500 | |
3 | 4 | 0 | .429 | |
2 | 5 | 0 | .286 | |
2 | 5 | 0 | .286 | |
| NFC West | W | L | T | PCT |
6 | 1 | 0 | .857 | |
4 | 3 | 0 | .571 | |
3 | 4 | 0 | .429 | |
2 | 5 | 0 | .286 |
Commanders
Bears
Panthers
Saints| AFC East | W | L | T | PCT |
|---|---|---|---|---|
5 | 1 | 0 | .833 | |
4 | 3 | 0 | .571 | |
2 | 5 | 0 | .286 | |
1 | 5 | 0 | .167 | |
| AFC North | W | L | T | PCT |
5 | 2 | 0 | .714 | |
5 | 2 | 0 | .714 | |
4 | 2 | 0 | .667 | |
4 | 3 | 0 | .571 | |
| AFC South | W | L | T | PCT |
4 | 2 | 0 | .667 | |
2 | 5 | 0 | .286 | |
2 | 5 | 0 | .286 | |
1 | 6 | 0 | .143 | |
| AFC West | W | L | T | PCT |
5 | 1 | 0 | .833 | |
5 | 2 | 0 | .714 | |
3 | 4 | 0 | .429 | |
0 | 6 | 0 | .000 |
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