The San Francisco 49ers are 71-45 in the regular season and playoffs against the AFC at home all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/27/1970 | 1-0 | vs | W 34-31 | 1.000 | 5 | 24 | 435 | 448 | ||||
| 2 | | 49ers | 10/25/1970 | 1-0 | vs | W 19-14 | 1.000 | 1 | 16 | 362 | 283 | ||||
| 3 | | 49ers | 10/31/1971 | 1-0 | vs | W 27-10 | 1.000 | 3 | 13 | 247 | 246 | ||||
| 4 | | 49ers | 12/6/1971 | 0-1 | vs | L 17-26 | .000 | 2 | 18 | 331 | 427 | ||||
| 5 | | 49ers | 9/17/1972 | 1-0 | vs | W 34-3 | 1.000 | 4 | 18 | 295 | 258 | ||||
| 6 | | 49ers | 11/12/1972 | 1-0 | vs | W 24-21 | 1.000 | 3 | 19 | 310 | 297 | ||||
| 7 | | 49ers | 12/15/1973 | 0-1 | vs | L 14-37 | .000 | 2 | 16 | 239 | 308 | ||||
| 8 | | 49ers | 9/29/1974 | 0-1 | vs | L 3-21 | .000 | 0 | 14 | 226 | 373 | ||||
| 9 | | 49ers | 10/27/1974 | 0-1 | vs | L 24-35 | .000 | 3 | 20 | 372 | 297 | ||||
| 10 | | 49ers | 12/7/1975 | 0-1 | vs | L 13-27 | .000 | 1 | 11 | 200 | 279 | ||||
| 11 | | 49ers | 10/3/1976 | 1-0 | vs | W 17-6 | 1.000 | 2 | 16 | 247 | 261 | ||||
| 12 | | 49ers | 9/25/1977 | 0-1 | vs | L 15-19 | .000 | 2 | 13 | 280 | 361 | ||||
| 13 | | 49ers | 10/1/1978 | 1-0 | vs | W 28-12 | 1.000 | 4 | 11 | 179 | 322 | ||||
| 14 | | 49ers | 11/27/1978 | 0-1 | vs | L 7-24 | .000 | 1 | 12 | 141 | 380 | ||||
| 15 | | 49ers | 10/7/1979 | 0-1 | vs | L 24-35 | .000 | 3 | 29 | 464 | 310 | ||||
| 16 | | 49ers | 11/18/1979 | 0-1 | vs | L 28-38 | .000 | 4 | 18 | 240 | 369 | ||||
| 17 | | 49ers | 11/30/1980 | 1-0 | vs | W 21-17 | 1.000 | 3 | 15 | 229 | 343 | ||||
| 18 | | 49ers | 12/21/1980 | 0-1 | vs | L 13-18 | .000 | 2 | 19 | 298 | 267 | ||||
| 19 | | 49ers | 11/15/1981 | 0-1 | vs | L 12-15 | .000 | 0 | 21 | 305 | 267 | ||||
| 20 | | 49ers | 12/13/1981 | 1-0 | vs | W 28-6 | 1.000 | 4 | 22 | 414 | 186 | ||||
| 21 | | 49ers | 9/12/1982 | 0-1 | vs | L 17-23 | .000 | 2 | 18 | 252 | 255 | ||||
| 22 | | 49ers | 12/11/1982 | 0-1 | vs | L 37-41 | .000 | 5 | 29 | 465 | 538 | ||||
| 23 | | 49ers | 10/30/1983 | 0-1 | vs | L 13-27 | .000 | 1 | 17 | 312 | 364 | ||||
| 24 | | 49ers | 11/6/1983 | 0-1 | vs | L 17-20 | .000 | 2 | 20 | 394 | 316 | ||||
| 25 | | 49ers | 10/14/1984 | 0-1 | vs | L 17-20 | .000 | 2 | 22 | 358 | 324 | ||||
| Average | .612 | 2.8 | 20.3 | 355.0 | 313.3 | ||||||||||
| Total | 71-45 | .612 | 327 | 2,360 | 41,177 | 36,338 | |||||||||
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More 49ers Stats
Team Leaders 
PASS
1,196
Purdy
RUSH
286
McCaffrey
REC
326
Evans
Team Rankings
PPG
30.8
3rd
OPP PPG
18.6
3rd
RUSH YDS/G
128.6
8th
PASS YDS/G
239.2
15th
Rams
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WAS
ATL
DAL
MIN
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NFL 2026 Rankings
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NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 1 | .700 | |
2 | 3 | 0 | .400 | |
2 | 3 | 0 | .400 | |
1 | 3 | 1 | .300 | |
| NFC North | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| NFC South | W | L | T | PCT |
2 | 2 | 0 | .500 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
1 | 4 | 0 | .200 | |
| NFC West | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 |
Giants
Eagles
Packers
Lions
Bears
Panthers
Buccaneers
Saints| AFC East | W | L | T | PCT |
|---|---|---|---|---|
4 | 1 | 0 | .800 | |
3 | 2 | 0 | .600 | |
2 | 3 | 0 | .400 | |
0 | 5 | 0 | .000 | |
| AFC North | W | L | T | PCT |
4 | 1 | 0 | .800 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| AFC South | W | L | T | PCT |
4 | 1 | 0 | .800 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
0 | 5 | 0 | .000 | |
| AFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
0 | 5 | 0 | .000 |
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