The San Francisco 49ers have a 48-23 record in the regular season and playoffs against the NFC since January 22, 2021.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/12/2021 | 1-0 | @ | W 41-33 | 1.000 | 5 | 21 | 442 | 430 | 33.3 | |||
| 2 | | 49ers | 9/19/2021 | 1-0 | @ | W 17-11 | 1.000 | 2 | 23 | 306 | 328 | 42.9 | 100.0 | ||
| 3 | | 49ers | 9/26/2021 | 0-1 | vs | L 28-30 | .000 | 4 | 26 | 298 | 353 | 63.6 | |||
| 4 | | 49ers | 10/3/2021 | 0-1 | vs | L 21-28 | .000 | 3 | 23 | 457 | 234 | 14.3 | 75.0 | ||
| 5 | | 49ers | 10/10/2021 | 0-1 | @ | L 10-17 | .000 | 1 | 19 | 338 | 304 | 27.3 | 20.0 | ||
| 6 | | 49ers | 10/31/2021 | 1-0 | @ | W 33-22 | 1.000 | 3 | 21 | 467 | 324 | 40.0 | 100.0 | ||
| 7 | | 49ers | 11/7/2021 | 0-1 | vs | L 17-31 | .000 | 2 | 22 | 337 | 437 | 40.0 | |||
| 8 | | 49ers | 11/15/2021 | 1-0 | vs | W 31-10 | 1.000 | 4 | 20 | 335 | 278 | 57.1 | 50.0 | ||
| 9 | | 49ers | 11/28/2021 | 1-0 | vs | W 34-26 | 1.000 | 4 | 23 | 423 | 323 | 41.7 | |||
| 10 | | 49ers | 12/5/2021 | 0-1 | @ | L 23-30 | .000 | 3 | 17 | 365 | 327 | 30.0 | 50.0 | ||
| 11 | | 49ers | 12/19/2021 | 1-0 | vs | W 31-13 | 1.000 | 4 | 23 | 397 | 275 | 54.5 | |||
| 12 | | 49ers | 1/9/2022 | 1-0 | @ | W 27-24 | 1.000 | 3 | 23 | 449 | 265 | 64.3 | |||
| 13 | | 49ers | 1/16/2022 | 1-0 | @ | W 23-17 | 1.000 | 2 | 21 | 341 | 307 | 46.2 | |||
| 14 | | 49ers | 1/22/2022 | 1-0 | @ | W 13-10 | 1.000 | 1 | 12 | 212 | 263 | 36.4 | 0.0 | ||
| 15 | | 49ers | 1/30/2022 | 0-1 | @ | L 17-20 | .000 | 2 | 16 | 282 | 396 | 33.3 | |||
| 16 | | 49ers | 9/11/2022 | 0-1 | @ | L 10-19 | .000 | 1 | 17 | 331 | 204 | 47.1 | 0.0 | ||
| 17 | | 49ers | 9/18/2022 | 1-0 | vs | W 27-7 | 1.000 | 3 | 25 | 373 | 216 | 40.0 | 66.7 | ||
| 18 | | 49ers | 10/3/2022 | 1-0 | vs | W 24-9 | 1.000 | 3 | 13 | 327 | 257 | 41.7 | 0.0 | ||
| 19 | | 49ers | 10/9/2022 | 1-0 | @ | W 37-15 | 1.000 | 5 | 22 | 397 | 308 | 58.3 | |||
| 20 | | 49ers | 10/16/2022 | 0-1 | @ | L 14-28 | .000 | 2 | 21 | 346 | 289 | 37.5 | 0.0 | ||
| 21 | | 49ers | 10/30/2022 | 1-0 | @ | W 31-14 | 1.000 | 4 | 22 | 368 | 223 | 55.6 | |||
| 22 | | 49ers | 11/21/2022 | 1-0 | @ | W 38-10 | 1.000 | 5 | 21 | 387 | 314 | 54.5 | |||
| 23 | | 49ers | 11/27/2022 | 1-0 | vs | W 13-0 | 1.000 | 1 | 21 | 317 | 260 | 38.5 | 50.0 | ||
| 24 | | 49ers | 12/11/2022 | 1-0 | vs | W 35-7 | 1.000 | 5 | 24 | 404 | 322 | 44.4 | 50.0 | ||
| 25 | | 49ers | 12/15/2022 | 1-0 | @ | W 21-13 | 1.000 | 3 | 15 | 381 | 277 | 46.2 | |||
| Average | .676 | 3.0 | 21.2 | 369.2 | 313.0 | 46.3 | 0.0 | ||||||||
| Total | 48-23 | .676 | 215 | 1,508 | 26,211 | 22,226 | 46.3 | 45.9 | |||||||
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More 49ers Stats
Team Leaders 
PASS
205
Purdy
RUSH
68
McCaffrey
REC
50
Robinson
Team Rankings
PPG
27.0
1st
OPP PPG
7.0
1st
RUSH YDS/G
174.0
1st
PASS YDS/G
205.0
1st
MIA
DEN
WAS
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
| NFC North | W | L | T | PCT |
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
| NFC South | W | L | T | PCT |
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
| NFC West | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 0 | 0 | ||
0 | 1 | 0 | .000 |
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