The Buffalo Bills have a record of 38-37-1 against the spread against the AFC since January 22, 2021.
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| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 1/24/2021 | 0-1 | +135 | @ | -162 | L 24-38 | +3 | -11 (N) | 55 | +7 (O) | 2 | 24 | 363 | 439 | 35.7 | 100.0 | ||
| 2 | | Bills | 9/12/2021 | 0-1 | -286 | vs | +229 | L 16-23 | -6.5 | -13.5 (N) | 48.5 | -9.5 (U) | 1 | 22 | 371 | 252 | 44.4 | 33.3 | ||
| 3 | | Bills | 9/19/2021 | 1-0 | -188 | @ | +159 | W 35-0 | -3.5 | +31.5 (Y) | 48 | -13 (U) | 5 | 21 | 314 | 216 | 53.8 | 100.0 | ||
| 4 | | Bills | 10/3/2021 | 1-0 | -1784 | vs | +957 | W 40-0 | -19 | +21 (Y) | 47.5 | -7.5 (U) | 4 | 26 | 450 | 109 | 41.7 | 50.0 | ||
| 5 | | Bills | 10/10/2021 | 1-0 | +124 | @ | -146 | W 38-20 | +3 | +21 (Y) | 56.5 | +1.5 (O) | 5 | 20 | 436 | 392 | 45.5 | |||
| 6 | | Bills | 10/18/2021 | 0-1 | -270 | @ | +218 | L 31-34 | -6 | -9 (N) | 53.5 | +11.5 (O) | 3 | 28 | 417 | 362 | 53.8 | 0.0 | ||
| 7 | | Bills | 10/31/2021 | 0-0-1 | -1046 | vs | +681 | W 26-11 | -15 | 0 (P) | 48.5 | -11.5 (U) | 3 | 24 | 351 | 262 | 46.2 | 0.0 | ||
| 8 | | Bills | 11/7/2021 | 0-1 | -1144 | @ | +704 | L 6-9 | -14.5 | -17.5 (N) | 48.5 | -33.5 (U) | 0 | 17 | 301 | 218 | 40.0 | 0.0 | ||
| 9 | | Bills | 11/14/2021 | 1-0 | -777 | @ | +533 | W 45-17 | -13.5 | +14.5 (Y) | 48.5 | +13.5 (O) | 6 | 26 | 489 | 366 | 57.1 | |||
| 10 | | Bills | 11/21/2021 | 0-1 | -310 | vs | +244 | L 15-41 | -7 | -33 (N) | 49.5 | +6.5 (O) | 2 | 19 | 311 | 370 | 50.0 | |||
| 11 | | Bills | 12/6/2021 | 0-1 | -147 | vs | +124 | L 10-14 | -3 | -7 (N) | 40 | -16 (U) | 1 | 16 | 230 | 241 | 30.8 | 0.0 | ||
| 12 | | Bills | 12/26/2021 | 1-0 | -107 | @ | -113 | W 33-21 | +1 | +13 (Y) | 43.5 | +10.5 (O) | 4 | 28 | 428 | 288 | 50.0 | 75.0 | ||
| 13 | | Bills | 1/9/2022 | 1-0 | -1163 | vs | +714 | W 27-10 | -16 | +1 (Y) | 43 | -6 (U) | 3 | 25 | 424 | 63 | 44.4 | 0.0 | ||
| 14 | | Bills | 1/15/2022 | 1-0 | -216 | vs | +175 | W 47-17 | -4.5 | +25.5 (Y) | 43 | +21 (O) | 7 | 29 | 482 | 305 | 85.7 | |||
| 15 | | Bills | 1/23/2022 | 0-1 | +112 | @ | -133 | L 36-42 | +2.5 | -3.5 (N) | 54 | +24 (O) | 5 | 23 | 422 | 552 | 42.9 | 100.0 | ||
| 16 | | Bills | 9/19/2022 | 1-0 | -453 | vs | +349 | W 41-7 | -10 | +24 (Y) | 47.5 | +0.5 (O) | 5 | 23 | 414 | 187 | 38.5 | 66.7 | ||
| 17 | | Bills | 9/25/2022 | 0-1 | -206 | @ | +171 | L 19-21 | -4.5 | -6.5 (N) | 54.5 | -14.5 (U) | 2 | 31 | 497 | 212 | 61.1 | 66.7 | ||
| 18 | | Bills | 10/2/2022 | 0-1 | -173 | @ | +144 | W 23-20 | -3.5 | -0.5 (N) | 50.5 | -7.5 (U) | 2 | 22 | 326 | 296 | 36.4 | 100.0 | ||
| 19 | | Bills | 10/9/2022 | 1-0 | -908 | vs | +611 | W 38-3 | -14 | +21 (Y) | 44.5 | -3.5 (U) | 5 | 21 | 552 | 364 | 55.6 | |||
| 20 | | Bills | 10/16/2022 | 1-0 | -148 | @ | +124 | W 24-20 | -2.5 | +1.5 (Y) | 54 | -10 (U) | 3 | 26 | 443 | 387 | 36.4 | 33.3 | ||
| 21 | | Bills | 11/6/2022 | 0-1 | -562 | @ | +410 | L 17-20 | -10.5 | -13.5 (N) | 46 | -9 (U) | 2 | 19 | 317 | 310 | 61.5 | 0.0 | ||
| 22 | | Bills | 11/20/2022 | 1-0 | -367 | vs | +290 | W 31-23 | -7.5 | +0.5 (Y) | 50.5 | +3.5 (O) | 2 | 22 | 357 | 396 | 27.3 | |||
| 23 | | Bills | 12/1/2022 | 1-0 | -204 | @ | +170 | W 24-10 | -4 | +10 (Y) | 43.5 | -9.5 (U) | 3 | 22 | 355 | 242 | 60.0 | |||
| 24 | | Bills | 12/11/2022 | 0-1 | -462 | vs | +356 | W 20-12 | -10 | -2 (N) | 43.5 | -11.5 (U) | 2 | 14 | 232 | 309 | 15.4 | |||
| 25 | | Bills | 12/17/2022 | 0-1 | -349 | vs | +273 | W 32-29 | -7 | -4 (N) | 44.5 | +16.5 (O) | 4 | 29 | 446 | 405 | 57.1 | |||
| Average | 0.7 | 3.3 | 22.1 | 371.6 | 314.6 | 45.8 | 0.0 | |||||||||||||
| Total | 38-37-1 | 251 | 1,681 | 28,243 | 23,911 | 45.8 | 64.3 | |||||||||||||
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More Bills Stats
Team Leaders 
PASS
1,793
Allen
RUSH
707
Cook
REC
401
Kincaid
Team Rankings
PPG
33.3
1st
OPP PPG
25.9
24th
RUSH YDS/G
148.4
3rd
PASS YDS/G
256.1
10th
Jets
MIN
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
5 | 2 | 1 | .688 | |
4 | 5 | 0 | .444 | |
2 | 5 | 1 | .313 | |
2 | 7 | 0 | .222 | |
| NFC North | W | L | T | PCT |
6 | 1 | 0 | .857 | |
6 | 2 | 0 | .750 | |
6 | 2 | 0 | .750 | |
6 | 3 | 0 | .667 | |
| NFC South | W | L | T | PCT |
3 | 5 | 0 | .375 | |
3 | 5 | 0 | .375 | |
3 | 5 | 0 | .375 | |
3 | 6 | 0 | .333 | |
| NFC West | W | L | T | PCT |
7 | 1 | 0 | .875 | |
5 | 4 | 0 | .556 | |
5 | 4 | 0 | .556 | |
3 | 6 | 0 | .333 |
Giants
Cowboys
Commanders
Eagles
Lions
Bears
Packers
Buccaneers
Panthers
Saints
Falcons
49ers
Seahawks
Rams
Cardinals| AFC East | W | L | T | PCT |
|---|---|---|---|---|
6 | 1 | 0 | .857 | |
5 | 4 | 0 | .556 | |
2 | 7 | 0 | .222 | |
1 | 7 | 0 | .125 | |
| AFC North | W | L | T | PCT |
6 | 2 | 0 | .750 | |
6 | 2 | 0 | .750 | |
5 | 4 | 0 | .556 | |
4 | 5 | 0 | .444 | |
| AFC South | W | L | T | PCT |
6 | 2 | 0 | .750 | |
3 | 5 | 0 | .375 | |
2 | 7 | 0 | .222 | |
1 | 7 | 0 | .125 | |
| AFC West | W | L | T | PCT |
7 | 2 | 0 | .778 | |
6 | 2 | 0 | .750 | |
4 | 5 | 0 | .444 | |
0 | 8 | 0 | .000 |
Bengals
Broncos
Raiders
Chargers