The Buffalo Bills had their highest over/under line in a game against the Chiefs on October 10, 2021, at 56.5 points.
| TEAM | DATE | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 10/10/2021 | +124 | @ | -146 | W 38-20 | +3 | +21 (Y) | 56.5 | +1.5 (O) | 5 | 20 | 436 | 392 | 45.5 | |||
| 2 | | Bills | 12/15/2024 | +124 | @ | -148 | W 48-42 | +2.5 | +8.5 (Y) | 56 | +34 (O) | 6 | 28 | 559 | 521 | 50.0 | 100.0 | ||
| 3 | | Bills | 11/15/2020 | +127 | @ | -151 | L 30-32 | +3 | +1 (Y) | 55.5 | +6.5 (O) | 3 | 22 | 369 | 453 | 46.2 | |||
| 4 | | Bills | 1/24/2021 | +135 | @ | -162 | L 24-38 | +3 | -11 (N) | 55 | +7 (O) | 2 | 24 | 363 | 439 | 35.7 | 100.0 | ||
| 5 | | Bills | 11/8/2020 | +147 | vs | -176 | W 44-34 | +3 | +13 (Y) | 55 | +23 (O) | 5 | 27 | 420 | 419 | 41.7 | |||
| 6 | | Bills | 12/7/2025 | -287 | vs | +233 | W 39-34 | -5.5 | -0.5 (N) | 54.5 | +18.5 (O) | 5 | 22 | 416 | 338 | 54.5 | 75.0 | ||
| 7 | | Bills | 11/24/2022 | -433 | @ | +338 | W 28-25 | -9.5 | -6.5 (N) | 54.5 | -1.5 (U) | 3 | 28 | 401 | 326 | 58.3 | |||
| 8 | | Bills | 9/25/2022 | -206 | @ | +171 | L 19-21 | -4.5 | -6.5 (N) | 54.5 | -14.5 (U) | 2 | 31 | 497 | 212 | 61.1 | 66.7 | ||
| 9 | | Bills | 10/19/2020 | +204 | vs | -246 | L 17-26 | +5.5 | -3.5 (N) | 54.5 | -11.5 (U) | 2 | 20 | 206 | 466 | 44.4 | |||
| 10 | | Bills | 10/16/2022 | -148 | @ | +124 | W 24-20 | -2.5 | +1.5 (Y) | 54 | -10 (U) | 3 | 26 | 443 | 387 | 36.4 | 33.3 | ||
| 11 | | Bills | 1/23/2022 | +112 | @ | -133 | L 36-42 | +2.5 | -3.5 (N) | 54 | +24 (O) | 5 | 23 | 422 | 552 | 42.9 | 100.0 | ||
| 12 | | Bills | 11/11/2012 | +600 | @ | -800 | L 31-37 | +13.5 | +7.5 (Y) | 54 | +14 (O) | 4 | 35 | 481 | 347 | 63.6 | 100.0 | ||
| 13 | | Bills | 9/25/2011 | +280 | vs | -340 | W 34-31 | +7 | +10 (Y) | 54 | +11 (O) | 4 | 24 | 448 | 495 | 36.4 | 0.0 | ||
| 14 | | Bills | 10/18/2021 | -270 | @ | +218 | L 31-34 | -6 | -9 (N) | 53.5 | +11.5 (O) | 3 | 28 | 417 | 362 | 53.8 | 0.0 | ||
| 15 | | Bills | 10/9/2011 | +150 | vs | -170 | W 31-24 | +3 | +10 (Y) | 53 | +2 (O) | 4 | 21 | 331 | 489 | 42.9 | |||
| 16 | | Bills | 10/6/2002 | vs | L 31-49 | +3 | -15 (N) | 53 | +27 (O) | 4 | 29 | 479 | 495 | 46.7 | 100.0 | ||||
| 17 | | Bills | 11/2/2025 | +115 | vs | -136 | W 28-21 | +2.5 | +9.5 (Y) | 52.5 | -3.5 (U) | 4 | 23 | 404 | 305 | 58.3 | 0.0 | ||
| 18 | | Bills | 9/7/2025 | +102 | vs | -122 | W 41-40 | +1.5 | +2.5 (Y) | 52.5 | +28.5 (O) | 5 | 29 | 497 | 432 | 46.7 | 100.0 | ||
| 19 | | Bills | 1/19/2025 | +104 | vs | -123 | W 27-25 | +1.5 | +3.5 (Y) | 52.5 | -0.5 (U) | 3 | 20 | 273 | 416 | 45.5 | 100.0 | ||
| 20 | | Bills | 10/1/2023 | -150 | vs | +127 | W 48-20 | -3 | +25 (Y) | 52.5 | +15.5 (O) | 6 | 24 | 414 | 393 | 50.0 | |||
| 21 | | Bills | 12/12/2021 | +154 | @ | -181 | L 27-33 | +3.5 | -2.5 (N) | 52.5 | +7.5 (O) | 3 | 27 | 466 | 488 | 15.4 | 66.7 | ||
| 22 | | Bills | 10/4/2020 | -178 | @ | +148 | W 30-23 | -3.5 | +3.5 (Y) | 52.5 | +0.5 (O) | 4 | 21 | 337 | 383 | 53.8 | 100.0 | ||
| 23 | | Bills | 9/8/2022 | -131 | @ | +110 | W 31-10 | -2.5 | +18.5 (Y) | 52 | -11 (U) | 4 | 23 | 413 | 243 | 90.0 | |||
| 24 | | Bills | 10/13/2020 | -166 | @ | +141 | L 16-42 | -3 | -29 (N) | 52 | +6 (O) | 2 | 23 | 370 | 334 | 76.5 | |||
| 25 | | Bills | 1/11/2026 | +106 | @ | -126 | W 27-24 | +1.5 | +4.5 (Y) | 51.5 | -0.5 (U) | 3 | 20 | 340 | 359 | 50.0 | 100.0 | ||
Results may be incomplete. StatMuse has complete team, game-level data for over/under lines going back to the 1979 season.
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More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |