The Buffalo Bills are 47-24 against the AFC in the regular-season and playoffs since January 22, 2021.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 1/24/2021 | 0-1 | @ | L 24-38 | .000 | 2 | 24 | 363 | 439 | 35.7 | 100.0 | ||
| 2 | | Bills | 9/12/2021 | 0-1 | vs | L 16-23 | .000 | 1 | 22 | 371 | 252 | 44.4 | 33.3 | ||
| 3 | | Bills | 9/19/2021 | 1-0 | @ | W 35-0 | 1.000 | 5 | 21 | 314 | 216 | 53.8 | 100.0 | ||
| 4 | | Bills | 10/3/2021 | 1-0 | vs | W 40-0 | 1.000 | 4 | 26 | 450 | 109 | 41.7 | 50.0 | ||
| 5 | | Bills | 10/10/2021 | 1-0 | @ | W 38-20 | 1.000 | 5 | 20 | 436 | 392 | 45.5 | |||
| 6 | | Bills | 10/18/2021 | 0-1 | @ | L 31-34 | .000 | 3 | 28 | 417 | 362 | 53.8 | 0.0 | ||
| 7 | | Bills | 10/31/2021 | 1-0 | vs | W 26-11 | 1.000 | 3 | 24 | 351 | 262 | 46.2 | 0.0 | ||
| 8 | | Bills | 11/7/2021 | 0-1 | @ | L 6-9 | .000 | 0 | 17 | 301 | 218 | 40.0 | 0.0 | ||
| 9 | | Bills | 11/14/2021 | 1-0 | @ | W 45-17 | 1.000 | 6 | 26 | 489 | 366 | 57.1 | |||
| 10 | | Bills | 11/21/2021 | 0-1 | vs | L 15-41 | .000 | 2 | 19 | 311 | 370 | 50.0 | |||
| 11 | | Bills | 12/6/2021 | 0-1 | vs | L 10-14 | .000 | 1 | 16 | 230 | 241 | 30.8 | 0.0 | ||
| 12 | | Bills | 12/26/2021 | 1-0 | @ | W 33-21 | 1.000 | 4 | 28 | 428 | 288 | 50.0 | 75.0 | ||
| 13 | | Bills | 1/9/2022 | 1-0 | vs | W 27-10 | 1.000 | 3 | 25 | 424 | 63 | 44.4 | 0.0 | ||
| 14 | | Bills | 1/15/2022 | 1-0 | vs | W 47-17 | 1.000 | 7 | 29 | 482 | 305 | 85.7 | |||
| 15 | | Bills | 1/23/2022 | 0-1 | @ | L 36-42 | .000 | 5 | 23 | 422 | 552 | 42.9 | 100.0 | ||
| 16 | | Bills | 9/19/2022 | 1-0 | vs | W 41-7 | 1.000 | 5 | 23 | 414 | 187 | 38.5 | 66.7 | ||
| 17 | | Bills | 9/25/2022 | 0-1 | @ | L 19-21 | .000 | 2 | 31 | 497 | 212 | 61.1 | 66.7 | ||
| 18 | | Bills | 10/2/2022 | 1-0 | @ | W 23-20 | 1.000 | 2 | 22 | 326 | 296 | 36.4 | 100.0 | ||
| 19 | | Bills | 10/9/2022 | 1-0 | vs | W 38-3 | 1.000 | 5 | 21 | 552 | 364 | 55.6 | |||
| 20 | | Bills | 10/16/2022 | 1-0 | @ | W 24-20 | 1.000 | 3 | 26 | 443 | 387 | 36.4 | 33.3 | ||
| 21 | | Bills | 11/6/2022 | 0-1 | @ | L 17-20 | .000 | 2 | 19 | 317 | 310 | 61.5 | 0.0 | ||
| 22 | | Bills | 11/20/2022 | 1-0 | vs | W 31-23 | 1.000 | 2 | 22 | 357 | 396 | 27.3 | |||
| 23 | | Bills | 12/1/2022 | 1-0 | @ | W 24-10 | 1.000 | 3 | 22 | 355 | 242 | 60.0 | |||
| 24 | | Bills | 12/11/2022 | 1-0 | vs | W 20-12 | 1.000 | 2 | 14 | 232 | 309 | 15.4 | |||
| 25 | | Bills | 12/17/2022 | 1-0 | vs | W 32-29 | 1.000 | 4 | 29 | 446 | 405 | 57.1 | |||
| Average | .662 | 3.3 | 22.2 | 371.5 | 313.5 | 46.2 | 0.0 | ||||||||
| Total | 47-24 | .662 | 234 | 1,573 | 26,373 | 22,255 | 46.2 | 63.2 | |||||||
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More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |