The Buffalo Bills have a 4-3 record in the regular-season and playoffs against the Rams on the road all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 12/15/1974 | 0-1 | @ | L 14-19 | .000 | 2 | 8 | 218 | 321 | ||||
| 2 | | Bills | 11/27/1983 | 0-1 | @ | L 17-41 | .000 | 2 | 22 | 345 | 355 | ||||
| 3 | | Bills | 12/10/1995 | 1-0 | @ | W 45-27 | 1.000 | 6 | 28 | 454 | 450 | 50.0 | |||
| 4 | | Bills | 9/28/2008 | 1-0 | @ | W 31-14 | 1.000 | 3 | 14 | 277 | 380 | 23.1 | |||
| 5 | | Bills | 10/9/2016 | 1-0 | @ | W 30-19 | 1.000 | 4 | 15 | 305 | 345 | 33.3 | |||
| 6 | | Bills | 9/8/2022 | 1-0 | @ | W 31-10 | 1.000 | 4 | 23 | 413 | 243 | 90.0 | |||
| 7 | | Bills | 12/8/2024 | 0-1 | @ | L 42-44 | .000 | 6 | 25 | 445 | 457 | 55.6 | |||
| Average | .571 | 3.9 | 19.3 | 351.0 | 364.4 | ||||||||||
| Total | 4-3 | .571 | 27 | 135 | 2,457 | 2,551 |
LA
STLMore Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
