The Arizona Cardinals are 3-5 against the spread as underdogs against the 49ers since July 31, 2022.
Showing
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Cardinals | 11/21/2022 | 0-1 | +341 | vs | -442 | L 10-38 | +9.5 | -18.5 (N) | 43 | +5 (O) | 1 | 19 | 314 | 387 | 50.0 | 0.0 | ||
| 2 | | Cardinals | 1/8/2023 | 0-1 | +693 | @ | -1057 | L 13-38 | +14.5 | -10.5 (N) | 39.5 | +11.5 (O) | 2 | 11 | 255 | 311 | 40.0 | 0.0 | ||
| 3 | | Cardinals | 10/1/2023 | 0-1 | +692 | @ | -1106 | L 16-35 | +14.5 | -4.5 (N) | 44 | +7 (O) | 2 | 23 | 362 | 395 | 53.3 | 66.7 | ||
| 4 | | Cardinals | 12/17/2023 | 0-1 | +529 | vs | -771 | L 29-45 | +12.5 | -3.5 (N) | 48 | +26 (O) | 3 | 22 | 436 | 406 | 43.8 | 75.0 | ||
| 5 | | Cardinals | 10/6/2024 | 1-0 | +278 | @ | -350 | W 24-23 | +7.5 | +8.5 (Y) | 48.5 | -1.5 (U) | 2 | 19 | 358 | 384 | 30.0 | 100.0 | ||
| 6 | | Cardinals | 9/21/2025 | 1-0 | +103 | @ | -123 | L 15-16 | +1.5 | +0.5 (Y) | 44.5 | -13.5 (U) | 1 | 16 | 260 | 355 | 33.3 | 100.0 | ||
| 7 | | Cardinals | 11/16/2025 | 0-1 | +158 | vs | -191 | L 22-41 | +3.5 | -15.5 (N) | 48.5 | +14.5 (O) | 3 | 24 | 488 | 281 | 42.9 | |||
| 8 | | Cardinals | 9/27/2026 | 1-0 | +308 | @ | -394 | L 30-36 | +7.5 | +1.5 (Y) | 48.5 | +17.5 (O) | 3 | 27 | 365 | 437 | 50.0 | 100.0 | ||
| Average | 4.7 | 2.1 | 20.1 | 354.8 | 369.5 | 43.9 | 0.1 | |||||||||||||
| Total | 3-5 | 17 | 161 | 2,838 | 2,956 | 43.9 | 62.5 |
ARI
SFMore NFL News
Chicago Bears acquire DT Jeffery Simmons in pricey trade with the Tennessee Titans
Raiders' run game sputters again as Ashton Jeanty struggles behind shaky blocking
Commanders are feeling urgency to play a complete game as they enter an important stretch
Bills coach Joe Brady questions NFL disciplinary process after Sam Franklin wins his appeal
Broncos linebacker Alex Singleton says 16 tackles can mean a bad day. Why 19 felt different
Garrett Wilson says he loves the Jets and wants to stay. But the frustrated wide receiver wants wins
More Cardinals Stats
Team Leaders 
PASS
1,600
Brissett
RUSH
245
Love
REC
472
McBride
Team Rankings
PPG
20.3
26th
OPP PPG
29.7
32nd
RUSH YDS/G
96.0
23rd
PASS YDS/G
229.6
21st
Seahawks
Rams
DAL
KC
WAS
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
4 | 2 | 1 | .643 | |
3 | 4 | 0 | .429 | |
2 | 5 | 0 | .286 | |
1 | 4 | 1 | .250 | |
| NFC North | W | L | T | PCT |
6 | 0 | 0 | 1.000 | |
5 | 2 | 0 | .714 | |
4 | 2 | 0 | .667 | |
4 | 3 | 0 | .571 | |
| NFC South | W | L | T | PCT |
3 | 3 | 0 | .500 | |
3 | 4 | 0 | .429 | |
2 | 5 | 0 | .286 | |
2 | 5 | 0 | .286 | |
| NFC West | W | L | T | PCT |
6 | 1 | 0 | .857 | |
4 | 3 | 0 | .571 | |
3 | 4 | 0 | .429 | |
2 | 5 | 0 | .286 |
Giants
Eagles
Vikings
Bears
Lions
Packers
Panthers
Falcons
Buccaneers
Saints| AFC East | W | L | T | PCT |
|---|---|---|---|---|
5 | 1 | 0 | .833 | |
4 | 3 | 0 | .571 | |
2 | 5 | 0 | .286 | |
1 | 5 | 0 | .167 | |
| AFC North | W | L | T | PCT |
5 | 2 | 0 | .714 | |
5 | 2 | 0 | .714 | |
4 | 2 | 0 | .667 | |
4 | 3 | 0 | .571 | |
| AFC South | W | L | T | PCT |
4 | 2 | 0 | .667 | |
2 | 5 | 0 | .286 | |
2 | 5 | 0 | .286 | |
1 | 6 | 0 | .143 | |
| AFC West | W | L | T | PCT |
5 | 1 | 0 | .833 | |
5 | 2 | 0 | .714 | |
3 | 4 | 0 | .429 | |
0 | 6 | 0 | .000 |
Bills
Patriots
Jets
Dolphins
Browns
Steelers
Bengals
Ravens
Jaguars
Colts
Texans
Titans
Broncos
Raiders
Chargers