The Arizona Cardinals have a point differential of -194 points in the regular-season and playoffs against the 49ers since 1967.
| TEAM | DATE | DIFF | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Cardinals | 9/22/1968 | -18 |  STL | @ |  SF | L 17-35 | 2 | 13 | 228 | 395 | ||
| 2 | | Cardinals | 10/24/1971 | -12 | STL | vs | SF | L 14-26 | 2 | 15 | 284 | 366 | ||
| 3 | | Cardinals | 10/6/1974 | 25 | STL | @ | SF | W 34-9 | 4 | 21 | 407 | 306 | ||
| 4 | | Cardinals | 10/31/1976 | 3 | STL | vs | SF | W 23-20 | 3 | 17 | 373 | 382 | ||
| 5 | | Cardinals | 11/12/1978 | 6 | STL | @ | SF | W 16-10 | 2 | 21 | 335 | 264 | ||
| 6 | | Cardinals | 12/2/1979 | 3 | STL | vs | SF | W 13-10 | 2 | 16 | 286 | 290 | ||
| 7 | | Cardinals | 9/14/1980 | -3 | STL | @ | SF | L 21-24 | 3 | 21 | 342 | 392 | ||
| 8 | | Cardinals | 11/21/1982 | -11 | STL | vs | SF | L 20-31 | 2 | 15 | 254 | 448 | ||
| 9 | | Cardinals | 9/18/1983 | -15 | STL | vs | SF | L 27-42 | 3 | 22 | 385 | 527 | ||
| 10 | | Cardinals | 11/9/1986 | -26 | STL | @ | SF | L 17-43 | 2 | 22 | 364 | 460 | ||
| 11 | | Cardinals | 10/18/1987 | -6 | STL | @ | SF | L 28-34 | 4 | 18 | 324 | 448 | ||
| 12 |  | Cardinals | 11/6/1988 | 1 |  PHX | vs | SF | W 24-23 | 3 | 21 | 355 | 357 | ||
| 13 | | Cardinals | 11/17/1991 | -4 | PHX | @ | SF | L 10-14 | 1 | 13 | 176 | 257 | 20.0 | 0.0 |
| 14 | | Cardinals | 11/1/1992 | 10 | PHX | vs | SF | W 24-14 | 3 | 21 | 342 | 330 | 68.8 | |
| 15 | | Cardinals | 10/24/1993 | -14 | PHX | @ | SF | L 14-28 | 2 | 25 | 429 | 428 | 58.8 | 66.7 |
| 16 |  | Cardinals | 9/27/1999 | -14 |  ARI | vs | SF | L 10-24 | 1 | 20 | 250 | 322 | 30.8 | 100.0 |
| 17 | | Cardinals | 10/1/2000 | -7 | ARI | @ | SF | L 20-27 | 2 | 16 | 365 | 345 | 23.1 | 66.7 |
| 18 | | Cardinals | 10/27/2002 | -10 | ARI | @ | SF | L 28-38 | 4 | 23 | 420 | 357 | 75.0 | 100.0 |
| 19 | | Cardinals | 12/21/2002 | -3 | ARI | vs | SF | L 14-17 | 2 | 14 | 184 | 358 | 53.8 | |
| 20 | | Cardinals | 10/26/2003 | 3 | ARI | vs | SF | W 16-13 | 1 | 18 | 314 | 255 | 40.0 | |
| 21 | | Cardinals | 12/7/2003 | -36 | ARI | @ | SF | L 14-50 | 2 | 18 | 210 | 496 | 21.4 | 66.7 |
| 22 | | Cardinals | 10/10/2004 | -3 | ARI | @ | SF | L 28-31 | 4 | 19 | 320 | 448 | 35.7 | 100.0 |
| 23 | | Cardinals | 12/12/2004 | -3 | ARI | vs | SF | L 28-31 | 3 | 25 | 374 | 352 | 43.8 | |
| 24 | | Cardinals | 10/2/2005 | 17 | ARI | vs | SF | W 31-14 | 2 | 24 | 463 | 168 | 42.1 | |
| 25 | | Cardinals | 12/4/2005 | 7 | ARI | @ | SF | W 17-10 | 1 | 18 | 404 | 220 | 31.3 | 0.0 |
| Average | -3.0 | 2.3 | 19.3 | 334.6 | 348.9 | |||||||||
| Total | -194 | 150 | 1,233 | 21,413 | 22,328 | |||||||||
More Cardinals Stats
Team Rankings
PPG
21.7
20th
OPP PPG
21.2
12th
RUSH YDS/G
113.2
17th
PASS YDS/G
213.7
20th
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Bills 
Patriots 
Steelers 
Bengals 
Colts 
Chargers 
Broncos | NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 4 | 2 | 0 | .667 |
 Commanders | 3 | 2 | 0 | .600 |
| NFC North | W | L | T | PCT |
 Lions | 4 | 1 | 0 | .800 |
 Packers | 3 | 1 | 1 | .700 |
| NFC South | W | L | T | PCT |
 Buccaneers | 5 | 1 | 0 | .833 |
 Panthers | 3 | 3 | 0 | .500 |
| NFC West | W | L | T | PCT |
| 49ers | 4 | 2 | 0 | .667 |
 Seahawks | 4 | 2 | 0 | .667 |
KC 
NYJ 
ATL 
LV 
CHI 
