The Arizona Cardinals have a 22-26 record in the regular-season and playoffs versus the 49ers since December 27, 1999.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Cardinals | 10/1/2000 | 0-1 |  ARI | @ |  SF | L 20-27 | .000 | 2 | 16 | 365 | 345 | 23.1 | 66.7 |
| 2 | | Cardinals | 10/27/2002 | 0-1 | ARI | @ | SF | L 28-38 | .000 | 4 | 23 | 420 | 357 | 75.0 | 100.0 |
| 3 | | Cardinals | 12/21/2002 | 0-1 | ARI | vs | SF | L 14-17 | .000 | 2 | 14 | 184 | 358 | 53.8 | |
| 4 | | Cardinals | 10/26/2003 | 1-0 | ARI | vs | SF | W 16-13 | 1.000 | 1 | 18 | 314 | 255 | 40.0 | |
| 5 | | Cardinals | 12/7/2003 | 0-1 | ARI | @ | SF | L 14-50 | .000 | 2 | 18 | 210 | 496 | 21.4 | 66.7 |
| 6 | | Cardinals | 10/10/2004 | 0-1 | ARI | @ | SF | L 28-31 | .000 | 4 | 19 | 320 | 448 | 35.7 | 100.0 |
| 7 | | Cardinals | 12/12/2004 | 0-1 | ARI | vs | SF | L 28-31 | .000 | 3 | 25 | 374 | 352 | 43.8 | |
| 8 | | Cardinals | 10/2/2005 | 1-0 | ARI | vs | SF | W 31-14 | 1.000 | 2 | 24 | 463 | 168 | 42.1 | |
| 9 | | Cardinals | 12/4/2005 | 1-0 | ARI | @ | SF | W 17-10 | 1.000 | 1 | 18 | 404 | 220 | 31.3 | 0.0 |
| 10 | | Cardinals | 9/10/2006 | 1-0 | ARI | vs | SF | W 34-27 | 1.000 | 4 | 23 | 367 | 393 | 50.0 | |
| 11 | | Cardinals | 12/24/2006 | 1-0 | ARI | @ | SF | W 26-20 | 1.000 | 2 | 21 | 372 | 223 | 50.0 | 100.0 |
| 12 | | Cardinals | 9/10/2007 | 0-1 | ARI | @ | SF | L 17-20 | .000 | 2 | 20 | 261 | 194 | 40.0 | |
| 13 | | Cardinals | 11/25/2007 | 0-1 | ARI | vs | SF | L 31-37 | .000 | 4 | 25 | 552 | 374 | 28.6 | 100.0 |
| 14 | | Cardinals | 9/7/2008 | 1-0 | ARI | @ | SF | W 23-13 | 1.000 | 2 | 18 | 285 | 291 | 31.3 | 66.7 |
| 15 | | Cardinals | 11/10/2008 | 1-0 | ARI | vs | SF | W 29-24 | 1.000 | 3 | 21 | 374 | 336 | 30.8 | 100.0 |
| 16 | | Cardinals | 9/13/2009 | 0-1 | ARI | vs | SF | L 16-20 | .000 | 1 | 17 | 299 | 203 | 28.6 | 0.0 |
| 17 | | Cardinals | 12/14/2009 | 0-1 | ARI | @ | SF | L 9-24 | .000 | 1 | 11 | 245 | 327 | 36.4 | 100.0 |
| 18 | | Cardinals | 11/29/2010 | 0-1 | ARI | vs | SF | L 6-27 | .000 | 0 | 8 | 203 | 386 | 18.2 | 0.0 |
| 19 | | Cardinals | 1/2/2011 | 0-1 | ARI | @ | SF | L 7-38 | .000 | 1 | 19 | 279 | 362 | 45.0 | 0.0 |
| 20 | | Cardinals | 11/20/2011 | 0-1 | ARI | @ | SF | L 7-23 | .000 | 1 | 11 | 229 | 431 | 11.1 | 0.0 |
| 21 | | Cardinals | 12/11/2011 | 1-0 | ARI | vs | SF | W 21-19 | 1.000 | 3 | 12 | 325 | 233 | 21.4 | |
| 22 | | Cardinals | 10/29/2012 | 0-1 | ARI | vs | SF | L 3-24 | .000 | 0 | 16 | 265 | 317 | 14.3 | 50.0 |
| 23 | | Cardinals | 12/30/2012 | 0-1 | ARI | @ | SF | L 13-27 | .000 | 1 | 11 | 262 | 407 | 25.0 | 100.0 |
| 24 | | Cardinals | 10/13/2013 | 0-1 | ARI | @ | SF | L 20-32 | .000 | 3 | 16 | 403 | 387 | 38.5 | 0.0 |
| 25 | | Cardinals | 12/29/2013 | 0-1 | ARI | vs | SF | L 20-23 | .000 | 2 | 19 | 482 | 375 | 26.7 | 75.0 |
| Average | .458 | 2.3 | 19.4 | 339.1 | 340.8 | 37.4 | 1.9 | ||||||||
| Total | 22-26 | .458 | 111 | 932 | 16,279 | 16,356 | 37.4 | 59.7 | |||||||
More Cardinals Stats
Team Rankings
PPG
20.5
22nd
OPP PPG
18.5
6th
RUSH YDS/G
105.8
22nd
PASS YDS/G
185.5
28th
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| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 4 | 0 | 0 | 1.000 |
 Commanders | 2 | 2 | 0 | .500 |
| NFC North | W | L | T | PCT |
 Lions | 3 | 1 | 0 | .750 |
 Packers | 2 | 1 | 1 | .625 |
| NFC South | W | L | T | PCT |
 Buccaneers | 3 | 1 | 0 | .750 |
 Falcons | 2 | 2 | 0 | .500 |
| NFC West | W | L | T | PCT |
| 49ers | 3 | 1 | 0 | .750 |
 Seahawks | 3 | 1 | 0 | .750 |
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