lowest int% in a single season with at least 280 yards per game and 12 gp

Tom Brady has the fewest interceptions per hundred attempts with 12+ games played and 280.0+ passing yards per game in a season, with 0.5 per hundred in 2016.

Interpreted as:

lowest int% by a player in a single season with at least 280 passing yards per game and 12 or more gp

	NAME	INT%	YDS/G	GP	SEASON	TM	CMP	ATT	PCT	YDS	AVG	TD	INT	RTG	TD%	SCK	SCKY
1	Tom Brady T. Brady	0.5	296.2	12	2016	NE	291	432	67.4	3,554	8.2	28	2	112.2	6.5	15	87
2	Patrick Mahomes P. Mahomes	1.0	316.0	15	2020	KC	390	588	66.3	4,740	8.1	38	6	108.2	6.5	22	147
3	Patrick Mahomes P. Mahomes	1.0	287.9	14	2019	KC	319	484	65.9	4,031	8.3	26	5	105.3	5.4	17	127
4	Tom Brady T. Brady	1.1	298.1	16	2015	NE	402	624	64.4	4,770	7.6	36	7	102.2	5.8	38	225
5	Matt Ryan M. Ryan	1.2	307.8	16	2018	ATL	422	608	69.4	4,924	8.1	35	7	108.1	5.8	42	296
6	Aaron Rodgers A. Rodgers	1.2	309.5	15	2011	GB	343	502	68.3	4,643	9.2	45	6	122.5	9.0	36	219
7	Tom Brady T. Brady	1.3	301.7	16	2012	NE	401	637	63.0	4,827	7.6	34	8	98.7	5.3	27	182
8	Deshaun Watson D. Watson	1.3	301.4	16	2020	HOU	382	544	70.2	4,823	8.9	33	7	112.4	6.1	49	293
9	Matt Ryan M. Ryan	1.3	309.0	16	2016	ATL	373	534	69.9	4,944	9.3	38	7	117.1	7.1	37	235
10	Tom Brady T. Brady	1.4	286.1	16	2017	NE	385	581	66.3	4,577	7.9	32	8	102.8	5.5	35	201
11	Joe Burrow J. Burrow	1.4	289.3	17	2024	CIN	460	652	70.6	4,918	7.5	43	9	108.5	6.6	48	278
12	Tom Brady T. Brady	1.4	300.4	16	2007	NE	398	578	68.9	4,806	8.3	50	8	117.2	8.7	21	128
13	Ben Roethlisberger B. Roethlisberger	1.5	309.5	16	2014	PIT	408	608	67.1	4,952	8.1	32	9	103.3	5.3	33	172
14	Peyton Manning P. Manning	1.5	342.3	16	2013	DEN	450	659	68.3	5,477	8.3	55	10	115.1	8.3	18	120
15	Rich Gannon R. Gannon	1.6	293.1	16	2002	OAK	418	618	67.6	4,689	7.6	26	10	97.3	4.2	36	214
16	Tony Romo T. Romo	1.6	280.2	16	2009	DAL	347	550	63.1	4,483	8.2	26	9	97.6	4.7	34	196
17	Tom Brady T. Brady	1.7	312.7	17	2021	TB	485	719	67.5	5,316	7.4	43	12	102.1	6.0	22	144
18	Dak Prescott D. Prescott	1.7	280.2	16	2021	DAL	411	597	68.8	4,483	7.5	37	10	104.4	6.2	30	144
19	Justin Herbert J. Herbert	1.7	289.1	15	2020	LAC	396	595	66.6	4,336	7.3	31	10	98.3	5.2	32	218
20	Philip Rivers P. Rivers	1.7	282.2	16	2017	LAC	360	575	62.6	4,515	7.9	28	10	96.0	4.9	18	120
21	Josh Allen J. Allen	1.7	284.0	16	2020	BUF	396	572	69.2	4,544	7.9	37	10	107.2	6.5	26	159
22	Drew Brees D. Brees	1.8	324.7	15	2015	NO	428	627	68.3	4,870	7.8	32	11	101.0	5.1	31	235
23	Matt Ryan M. Ryan	1.8	286.3	16	2020	ATL	407	626	65.0	4,581	7.3	26	11	93.3	4.2	41	257
24	Kyle Orton K. Orton	1.8	281.0	13	2010	DEN	293	498	58.8	3,653	7.3	20	9	87.5	4.0	34	243
25	Dak Prescott D. Prescott	1.8	306.4	16	2019	DAL	388	596	65.1	4,902	8.2	30	11	99.7	5.0	23	151

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StatMuse has season-level data for interceptions per hundred attempts and passing yards per game going back to the 1932 season.

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Tom Brady has the fewest interceptions per hundred attempts with 12+ games played and 280.0+ passing yards per game in a season, with 0.5 per hundred in 2016.

Interpreted as:

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