Drew Brees had the most games with 375+ passing yards, with 36 games.

Interpreted as:

most career 375+ pass yard regular-season games by a player

	NAME	GP	YDS	CMP	ATT	PCT	AVG	YDS/G	TD	INT	RTG	TD%	INT%	SCK	SCKY
1	Drew Brees D. Brees	36	14,729	1,147	1,623	70.7	9.1	409.1	114	30	114.5	7.0	1.8	52	382
2	Tom Brady T. Brady	29	11,817	923	1,335	69.1	8.9	407.5	94	20	113.8	7.0	1.5	60	375
3	Peyton Manning P. Manning	22	9,101	650	981	66.3	9.3	413.7	76	22	112.4	7.7	2.2	24	144
4	Ben Roethlisberger B. Roethlisberger	21	8,857	705	1,031	68.4	8.6	421.8	57	24	103.6	5.5	2.3	53	330
5	Matthew Stafford M. Stafford	20	8,274	600	933	64.3	8.9	413.7	50	15	103.8	5.4	1.6	39	271
6	Philip Rivers P. Rivers	18	7,397	547	789	69.3	9.4	410.9	47	20	108.2	6.0	2.5	33	192
7	Dan Marino D. Marino	18	7,627	527	865	60.9	8.8	423.7	59	28	98.8	6.8	3.2	25	202
8	Patrick Mahomes P. Mahomes	16	6,659	503	713	70.5	9.3	416.2	53	14	116.4	7.4	2.0	27	185
9	Dak Prescott D. Prescott	15	6,357	485	717	67.6	8.9	423.8	42	14	106.8	5.9	2.0	28	195
10	Matt Ryan M. Ryan	15	6,124	486	683	71.2	9.0	408.3	35	11	109.1	5.1	1.6	31	189
11	Eli Manning E. Manning	14	5,844	418	631	66.2	9.3	417.4	34	19	101.3	5.4	3.0	20	154
12	Aaron Rodgers A. Rodgers	13	5,418	370	550	67.3	9.9	416.8	38	5	118.4	6.9	0.9	39	251
13	Kirk Cousins K. Cousins	12	5,114	400	568	70.4	9.0	426.2	36	9	112.8	6.3	1.6	27	188
14	Warren Moon W. Moon	12	4,984	372	577	64.5	8.6	415.3	29	18	95.6	5.0	3.1	29	195
15	Joe Montana J. Montana	11	4,613	319	494	64.6	9.3	419.4	34	11	108.5	6.9	2.2	27	198
16	Jared Goff J. Goff	10	4,265	318	460	69.1	9.3	426.5	33	8	115.0	7.2	1.7	13	110
17	Jameis Winston J. Winston	10	4,155	304	466	65.2	8.9	415.5	32	18	100.4	6.9	3.9	27	156
18	Carson Palmer C. Palmer	10	4,089	313	467	67.0	8.8	408.9	27	12	103.0	5.8	2.6	19	145
19	Kurt Warner K. Warner	10	4,129	307	433	70.9	9.5	412.9	21	19	98.8	4.8	4.4	22	154
20	Dan Fouts D. Fouts	10	4,140	283	447	63.3	9.3	414.0	31	16	101.6	6.9	3.6
21	Joe Burrow J. Burrow	9	3,881	302	408	74.0	9.5	431.2	32	5	124.4	7.8	1.2	30	184
22	Drew Bledsoe D. Bledsoe	9	3,721	288	447	64.4	8.3	413.4	22	12	95.7	4.9	2.7	22	142
23	Brett Favre B. Favre	9	3,576	267	416	64.2	8.6	397.3	23	12	97.8	5.5	2.9	15	120
24	Boomer Esiason B. Esiason	9	3,773	258	407	63.4	9.3	419.2	25	17	96.6	6.1	4.2	19	125
25	Derek Carr D. Carr	8	3,342	249	398	62.6	8.4	417.8	21	5	101.6	5.3	1.3	17	114

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Drew Brees had the most games with 375+ passing yards, with 36 games.

Interpreted as:

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