Mario Williams has the most sacks for the Bills in a game, with 4.5 sacks against the Panthers on September 15, 2013.
| NAME | SCK | DATE | TM | OPP | TKL | AST | COMB | SCKY | INT | INT YDS | INT TD | FF | FR | FR TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | M. Williams | 4.5 | 9/15/2013 |  BUF | vs |  CAR | 5 | 1 | 6 | 24.5 | 0 | 0 | 0 | 0 | 0 | 0 |
| 2 |  | B. Smith | 4.0 | 9/18/1994 | BUF | @ |  HOU | 0 | 0 | 0 | 0 | ||||||
| 3 | | B. Smith | 4.0 | 12/9/1990 | BUF | @ |  IND | 0 | 0 | 0 | 0 | ||||||
| 4 | | C. Bennett | 4.0 | 12/27/1987 | BUF | @ |  PHI | 0 | 0 | 0 | 0 | ||||||
| 5 | | M. Williams | 3.5 | 11/13/2014 | BUF | @ |  MIA | 4 | 1 | 5 | 21 | 0 | 0 | 0 | 0 | 0 | 0 |
| 6 | | G. Rousseau | 3.0 | 9/8/2024 | BUF | vs |  ARI | 6 | 0 | 6 | 11 | 0 | 0 | 0 | 1 | 0 | 0 |
| 7 | | J. Phillips | 3.0 | 10/6/2019 | BUF | @ |  TEN | 3 | 0 | 3 | 23 | 0 | 0 | 0 | 0 | 0 | 0 |
| 8 | | L. Alexander | 3.0 | 10/9/2016 | BUF | @ |  LA | 7 | 0 | 7 | 19 | 0 | 0 | 0 | 0 | 0 | 0 |
| 9 | | M. Dareus | 3.0 | 11/9/2014 | BUF | vs |  KC | 4 | 3 | 7 | 15 | 0 | 0 | 0 | 0 | 0 | 0 |
| 10 | | M. Dareus | 3.0 | 10/5/2014 | BUF | @ |  DET | 5 | 0 | 5 | 18 | 0 | 0 | 0 | 1 | 0 | 0 |
| 11 | | M. Williams | 3.0 | 11/25/2012 | BUF | @ | IND | 3 | 0 | 3 | 8 | 0 | 0 | 0 | 0 | 0 | 0 |
| 12 | | C. Kelsay | 3.0 | 12/24/2011 | BUF | vs |  DEN | 7 | 3 | 10 | 27 | 0 | 0 | 0 | 1 | 0 | 0 |
| 13 | | A. Schobel | 3.0 | 12/27/2009 | BUF | @ |  ATL | 4 | 0 | 4 | 16 | 0 | 0 | 0 | 2 | 0 | 0 |
| 14 | | A. Schobel | 3.0 | 12/10/2006 | BUF | @ |  NYJ | 6 | 3 | 9 | 31 | 0 | 0 | 0 | 1 | 0 | 0 |
| 15 | | R. Denney | 3.0 | 9/17/2006 | BUF | @ | MIA | 4 | 0 | 4 | 33 | 0 | 0 | 0 | 1 | 0 | 0 |
| 16 | | L. Milloy | 3.0 | 11/21/2004 | BUF | vs | STL | 6 | 0 | 6 | 22 | 0 | 0 | 0 | 0 | 0 | 0 |
| 17 | | A. Schobel | 3.0 | 11/30/2003 | BUF | @ |  NYG | 5 | 0 | 5 | 18 | 0 | 0 | 0 | 0 | 1 | 0 |
| 18 | | P. Williams | 3.0 | 12/6/1998 | BUF | @ |  CIN | 0 | 0 | 0 | 0 | ||||||
| 19 | | B. Paup | 3.0 | 9/7/1997 | BUF | @ |  NYJ | 0 | 0 | 0 | 0 | ||||||
| 20 | | B. Smith | 3.0 | 9/8/1996 | BUF | vs |  NE | 0 | 0 | 0 | 0 | ||||||
| 21 | | B. Smith | 3.0 | 12/3/1995 | BUF | @ |  SF | 0 | 0 | 0 | 0 | ||||||
| 22 | | B. Paup | 3.0 | 11/5/1995 | BUF | @ | IND | 0 | 0 | 0 | 0 | ||||||
| 23 | | B. Paup | 3.0 | 9/17/1995 | BUF | vs | IND | 0 | 0 | 0 | 0 | ||||||
| 24 | | B. Smith | 3.0 | 9/20/1992 | BUF | vs | IND | 0 | 0 | 0 | 0 | ||||||
| 25 | | B. Smith | 3.0 | 10/22/1989 | BUF | vs | NYJ | 0 | 0 | 0 | 0 | ||||||
StatMuse has game-level data for sacks going back to the 1982 season.
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33.3
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OPP PPG
22.5
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163.5
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PASS YDS/G
249.0
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|---|---|---|---|---|
| Eagles | 4 | 0 | 0 | 1.000 |
 Commanders | 2 | 2 | 0 | .500 |
| NFC North | W | L | T | PCT |
| Lions | 3 | 1 | 0 | .750 |
 Packers | 2 | 1 | 1 | .625 |
| NFC South | W | L | T | PCT |
 Buccaneers | 3 | 1 | 0 | .750 |
| Falcons | 2 | 2 | 0 | .500 |
| NFC West | W | L | T | PCT |
| 49ers | 4 | 1 | 0 | .800 |
 Seahawks | 3 | 1 | 0 | .750 |
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