Barry Sanders had the most games with 150+ rushing yards, with 25 games.

Interpreted as:

most regular-season games by a player of 150+ rush yds

	NAME	GP	RUSH YDS	ATT	YPC	RUSH YDS/G	RUSH TD	REC YDS	REC	TRG	AVG	REC YDS/G	REC TD
1	Barry Sanders B. Sanders	25	4,464	614	7.3	178.6	33	312	45		6.9	12.5	1
2	Walter Payton W. Payton	20	3,546	576	6.2	177.3	27	287	38		7.6	14.4	0
3	Derrick Henry D. Henry	19	3,598	494	7.3	189.4	38	255	27	32	9.4	13.4	2
4	Adrian Peterson A. Peterson	19	3,564	513	6.9	187.6	25	229	36	55	6.4	12.1	1
5	Emmitt Smith E. Smith	18	3,001	485	6.2	166.7	27	274	55	0	5.0	15.2	1
6	Eric Dickerson E. Dickerson	18	3,215	526	6.1	178.6	27	254	24		10.6	14.1	0
7	LaDainian Tomlinson L. Tomlinson	16	3,029	430	7.0	189.3	34	404	73	100	5.5	25.3	2
8	O.J. Simpson	16	3,106	435	7.1	194.1	21	138	15		9.2	8.6	0
9	Earl Campbell E. Campbell	14	2,576	468	5.5	184.0	21	28	8		3.5	2.0	0
10	Jim Brown J. Brown	14	2,544	342	7.4	181.7	21	309	26		11.9	22.1	3
11	Jonathan Taylor J. Taylor	12	2,236	323	6.9	186.3	22	201	22	27	9.1	16.8	3
12	Ahman Green A. Green	12	2,008	271	7.4	167.3	11	236	37	49	6.4	19.7	2
13	Terrell Davis T. Davis	12	2,202	350	6.3	183.5	17	223	27		8.3	18.6	2
14	Marshall Faulk M. Faulk	12	2,204	290	7.6	183.7	18	581	62	64	9.4	48.4	5
15	Shaun Alexander S. Alexander	11	1,988	321	6.2	180.7	18	51	9	15	5.7	4.6	1
16	Priest Holmes P. Holmes	11	1,902	292	6.5	172.9	17	375	40	44	9.4	34.1	4
17	Saquon Barkley S. Barkley	10	1,732	233	7.4	173.2	11	279	30	36	9.3	27.9	3
18	LeSean McCoy L. McCoy	10	1,668	256	6.5	166.8	11	76	16	19	4.8	7.6	0
19	Jamal Lewis J. Lewis	10	1,956	278	7.0	195.6	12	124	14	19	8.9	12.4	0
20	Tony Dorsett T. Dorsett	10	1,654	222	7.5	165.4	9	94	13		7.2	9.4	0
21	Jamaal Charles J. Charles	9	1,696	206	8.2	188.4	10	169	20	30	8.5	18.8	1
22	Chris Johnson C. Johnson	9	1,586	192	8.3	176.2	12	164	22	31	7.5	18.2	1
23	Larry Johnson L. Johnson	9	1,566	282	5.6	174.0	18	76	13	22	5.8	8.4	1
24	Fred Taylor F. Taylor	9	1,588	247	6.4	176.4	15	119	19	24	6.3	13.2	1
25	Corey Dillon C. Dillon	9	1,757	260	6.8	195.2	14	94	16	22	5.9	10.4	1

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StatMuse has game-level data for rushing yards going back to the 1960 season.

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Bears	11	6	0	.647
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AFC East	W	L	T	PCT
Patriots - y	14	3	0	.824
Bills - w	12	5	0	.706
Dolphins - e	7	10	0	.412
Jets - e	3	14	0	.176
AFC North	W	L	T	PCT
Steelers - y	10	7	0	.588
Ravens - e	8	9	0	.471
Bengals - e	6	11	0	.353
Browns - e	5	12	0	.294
AFC South	W	L	T	PCT
Jaguars - y	13	4	0	.765
Texans - w	12	5	0	.706
Colts - e	8	9	0	.471
Titans - e	3	14	0	.176
AFC West	W	L	T	PCT
Broncos - z*	14	3	0	.824
Chargers - w	11	6	0	.647
Chiefs - e	6	11	0	.353
Raiders - e	3	14	0	.176

NFC East	W	L	T	PCT
Eagles - y	11	6	0	.647
Cowboys - e	7	9	1	.441
Commanders - e	5	12	0	.294
Giants - e	4	13	0	.235
NFC North	W	L	T	PCT
Bears - y	11	6	0	.647
Packers - w	9	7	1	.559
Vikings - e	9	8	0	.529
Lions - e	9	8	0	.529
NFC South	W	L	T	PCT
Panthers - y	8	9	0	.471
Buccaneers - e	8	9	0	.471
Falcons - e	8	9	0	.471
Saints - e	6	11	0	.353
NFC West	W	L	T	PCT
Seahawks - z*	14	3	0	.824
Rams - w	12	5	0	.706
49ers - w	12	5	0	.706
Cardinals - e	3	14	0	.176