James Cook III has rushed for the most yards in a game versus the Panthers, with 216 yards on October 26.
Interpreted as:
most rushing yards by a player vs. the panthers in a single regular-season game all-time| NAME | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | J. Cook III | 216 | 10/26/2025 |  BUF | @ |  CAR | 19 | 11.4 | 2 | 0 | 0 | 0 | 0 | |
| 2 |  | D. Ward | 215 | 12/21/2008 |  NYG | vs | CAR | 15 | 14.3 | 0 | -5 | 1 | 2 | -5.0 | 0 |
| 3 |  | M. Forte | 205 | 10/2/2011 |  CHI | vs | CAR | 25 | 8.2 | 1 | 23 | 4 | 5 | 5.8 | 0 |
| 4 |  | M. Faulk | 202 | 12/23/2001 |  STL | @ | CAR | 30 | 6.7 | 2 | 50 | 3 | 3 | 16.7 | 0 |
| 5 | | S. Alexander | 195 | 10/31/2004 |  SEA | vs | CAR | 32 | 6.1 | 1 | 13 | 3 | 4 | 4.3 | 1 |
| 6 | | J. Jones | 194 | 12/24/2005 |  DAL | @ | CAR | 34 | 5.7 | 2 | 17 | 2 | 2 | 8.5 | 0 |
| 7 | | R. Droughns | 193 | 10/10/2004 |  DEN | vs | CAR | 30 | 6.4 | 0 | 18 | 4 | 5 | 4.5 | 1 |
| 8 |  | R. Jones | 192 | 11/15/2020 |  TB | @ | CAR | 23 | 8.3 | 1 | 6 | 1 | 2 | 6.0 | 0 |
| 9 | | M. Faulk | 183 | 11/11/2001 | STL | vs | CAR | 15 | 12.2 | 2 | 14 | 4 | 5 | 3.5 | 0 |
| 10 | | B. Brown | 178 | 11/26/2012 |  PHI | vs | CAR | 19 | 9.4 | 2 | 11 | 4 | 5 | 2.8 | 0 |
| 11 |  | B. Robinson | 170 | 1/5/2025 |  ATL | vs | CAR | 28 | 6.1 | 2 | 3 | 2 | 5 | 1.5 | 0 |
| 12 | | M. Forte | 166 | 10/10/2010 | CHI | @ | CAR | 22 | 7.5 | 2 | 22 | 2 | 2 | 11.0 | 0 |
| 13 |  | C. Martin | 159 | 10/28/2001 |  NYJ | @ | CAR | 27 | 5.9 | 0 | 39 | 7 | 7 | 5.6 | 0 |
| 14 |  | A. Kamara | 155 | 11/3/2024 |  NO | @ | CAR | 29 | 5.3 | 0 | 60 | 6 | 9 | 10.0 | 0 |
| 15 |  | J. Mixon | 153 | 11/6/2022 |  CIN | vs | CAR | 22 | 7.0 | 4 | 58 | 4 | 5 | 14.5 | 1 |
| 16 |  | B. Irving | 152 | 12/1/2024 | TB | @ | CAR | 25 | 6.1 | 1 | 33 | 3 | 3 | 11.0 | 0 |
| 17 |  | R. Dowdle | 149 | 12/15/2024 | DAL | @ | CAR | 25 | 6.0 | 0 | 0 | 0 | 0 | 0 | |
| 18 |  | L. Bell | 147 | 9/21/2014 |  PIT | @ | CAR | 21 | 7.0 | 0 | 10 | 2 | 4 | 5.0 | 0 |
| 19 | | R. Williams | 147 | 10/14/2001 | NO | @ | CAR | 31 | 4.7 | 1 | 31 | 4 | 7 | 7.8 | 0 |
| 20 |  | A. Jones Sr. | 145 | 12/19/2020 |  GB | vs | CAR | 20 | 7.3 | 1 | 13 | 3 | 4 | 4.3 | 0 |
| 21 | | T. Canidate | 145 | 11/11/2001 | STL | vs | CAR | 16 | 9.1 | 1 | 1 | 1 | 2 | 1.0 | 0 |
| 22 | | R. Williams | 144 | 10/15/2000 | NO | vs | CAR | 38 | 3.8 | 2 | 35 | 3 | 4 | 11.7 | 0 |
| 23 |  | T. Etienne Jr. | 143 | 9/7/2025 |  JAX | vs | CAR | 16 | 8.9 | 0 | 13 | 3 | 3 | 4.3 | 0 |
| 24 |  | E. Elliott | 143 | 10/3/2021 | DAL | vs | CAR | 20 | 7.2 | 1 | 0 | 0 | 1 | 0 | |
| 25 |  | N. Chubb | 141 | 9/11/2022 |  CLE | @ | CAR | 22 | 6.4 | 0 | 2 | 1 | 1 | 2.0 | 0 |
Results may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.
More Bills Stats
Team Rankings
PPG
28.1
5th
OPP PPG
21.6
13th
RUSH YDS/G
155.7
1st
PASS YDS/G
240.5
11th
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