most single season passing yards per game all-time playing 16 or more games

Peyton Manning has gained the most passing yards per game with 16+ games played in a season, with 342.3 per game in 2013.

Interpreted as:

most single season passing yards per game by a player all-time playing 16 or more games

	NAME	YDS/G	GP	SEASON	TM	CMP	ATT	PCT	YDS	AVG	TD	INT	RTG	TD%	INT%	SCK	SCKY
1	Peyton Manning P. Manning	342.3	16	2013	DEN	450	659	68.3	5,477	8.3	55	10	115.1	8.3	1.5	18	120
2	Drew Brees D. Brees	342.3	16	2011	NO	468	657	71.2	5,476	8.3	46	14	110.6	7.0	2.1	24	158
3	Tom Brady T. Brady	327.2	16	2011	NE	401	611	65.6	5,235	8.6	39	12	105.6	6.4	2.0	32	173
4	Drew Brees D. Brees	325.5	16	2016	NO	471	673	70.0	5,208	7.7	37	15	101.7	5.5	2.2	27	184
5	Drew Brees D. Brees	323.6	16	2012	NO	422	670	63.0	5,177	7.7	43	19	96.3	6.4	2.8	26	190
6	Drew Brees D. Brees	322.6	16	2013	NO	446	650	68.6	5,162	7.9	39	12	104.7	6.0	1.8	37	244
7	Ben Roethlisberger B. Roethlisberger	320.6	16	2018	PIT	452	675	67.0	5,129	7.6	34	16	96.5	5.0	2.4	24	166
8	Jameis Winston J. Winston	319.3	16	2019	TB	380	626	60.7	5,109	8.2	33	30	84.3	5.3	4.8	47	282
9	Patrick Mahomes P. Mahomes	318.6	16	2018	KC	383	580	66.0	5,097	8.8	50	12	113.8	8.6	2.1	26	171
10	Dan Marino D. Marino	317.8	16	1984	MIA	362	564	64.2	5,084	9.0	48	17	108.9	8.5	3.0	13	120
11	Drew Brees D. Brees	316.8	16	2008	NO	413	635	65.0	5,069	8.0	34	17	96.2	5.4	2.7	13	92
12	Matthew Stafford M. Stafford	314.9	16	2011	DET	421	663	63.5	5,038	7.6	41	16	97.2	6.2	2.4	36	257
13	Tom Brady T. Brady	312.7	17	2021	TB	485	719	67.5	5,316	7.4	43	12	102.1	6.0	1.7	22	144
14	Matthew Stafford M. Stafford	310.4	16	2012	DET	435	727	59.8	4,967	6.8	20	17	79.8	2.8	2.3	29	212
15	Drew Brees D. Brees	309.5	16	2014	NO	456	659	69.2	4,952	7.5	33	17	97.0	5.0	2.6	29	186
16	Ben Roethlisberger B. Roethlisberger	309.5	16	2014	PIT	408	608	67.1	4,952	8.1	32	9	103.3	5.3	1.5	33	172
17	Matt Ryan M. Ryan	309.0	16	2016	ATL	373	534	69.9	4,944	9.3	38	7	117.1	7.1	1.3	37	235
18	Patrick Mahomes P. Mahomes	308.8	17	2022	KC	435	648	67.1	5,250	8.1	41	12	105.2	6.3	1.9	26	188
19	Eli Manning E. Manning	308.3	16	2011	NYG	359	589	61.0	4,933	8.4	29	16	92.9	4.9	2.7	28	199
20	Matt Ryan M. Ryan	307.8	16	2018	ATL	422	608	69.4	4,924	8.1	35	7	108.1	5.8	1.2	42	296
21	Kirk Cousins K. Cousins	307.3	16	2016	WAS	406	606	67.0	4,917	8.1	25	12	97.2	4.1	2.0	23	190
22	Tony Romo T. Romo	306.4	16	2012	DAL	425	648	65.6	4,903	7.6	28	19	90.5	4.3	2.9	36	263
23	Dak Prescott D. Prescott	306.4	16	2019	DAL	388	596	65.1	4,902	8.2	30	11	99.7	5.0	1.8	23	151
24	Kurt Warner K. Warner	301.9	16	2001	STL	375	546	68.7	4,830	8.8	36	22	101.4	6.6	4.0	38	233
25	Tom Brady T. Brady	301.7	16	2012	NE	401	637	63.0	4,827	7.6	34	8	98.7	5.3	1.3	27	182

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StatMuse has season-level data for passing yards per game going back to the 1932 season.

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Thu 9/4	KC	@	LAC	21-27
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Sun 10/19	LAR	@	JAX	9:30 AM
Sun 10/19	NE	@	TEN	1:00 PM
Sun 10/19	NO	@	CHI	1:00 PM
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Peyton Manning has gained the most passing yards per game with 16+ games played in a season, with 342.3 per game in 2013.

Interpreted as:

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