Peyton Manning had a record of 27-42 when throwing 2+ interceptions.

peyton career record in games with 2 interceptions
Interpreted as:
peyton career record in games with 2 or more passing interceptions
NAMEGPRECW%INTCMPATTPCTYDSAVGYDS/GTDTD%INT%SCKSCKYRATE
Peyton ManningPeyton Manning6927-42.3911661,6632,67562.219,1607.2277.71284.86.28754773.8
StatMuse has game-level data for intercepted passes going back to the 1950 season.

See Trending NFL Searches