The San Francisco 49ers have a record of 10-4 in the month of September against the AFC East all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/24/1972 | 0-1 | @ | L 20-27 | .000 | 2 | 10 | 202 | 233 | ||||
| 2 | | 49ers | 9/16/1973 | 0-1 | @ | L 13-21 | .000 | 1 | 16 | 252 | 279 | ||||
| 3 | | 49ers | 9/25/1977 | 0-1 | vs | L 15-19 | .000 | 2 | 13 | 280 | 361 | ||||
| 4 | | 49ers | 9/21/1980 | 1-0 | @ | W 37-27 | 1.000 | 5 | 24 | 376 | 460 | ||||
| 5 | | 49ers | 9/28/1986 | 1-0 | @ | W 31-16 | 1.000 | 4 | 16 | 314 | 437 | ||||
| 6 | | 49ers | 9/10/1989 | 1-0 | @ | W 30-24 | 1.000 | 3 | 24 | 404 | 344 | ||||
| 7 | | 49ers | 9/13/1992 | 0-1 | vs | L 31-34 | .000 | 4 | 26 | 598 | 488 | 61.5 | 100.0 | ||
| 8 | | 49ers | 9/20/1992 | 1-0 | @ | W 31-14 | 1.000 | 4 | 19 | 335 | 311 | 46.2 | 0.0 | ||
| 9 | | 49ers | 9/17/1995 | 1-0 | vs | W 28-3 | 1.000 | 4 | 21 | 363 | 302 | 38.5 | 100.0 | ||
| 10 | | 49ers | 9/6/1998 | 1-0 | vs | W 36-30 | 1.000 | 5 | 26 | 557 | 465 | 33.3 | 100.0 | ||
| 11 | | 49ers | 9/30/2012 | 1-0 | @ | W 34-0 | 1.000 | 4 | 26 | 381 | 145 | 33.3 | 100.0 | ||
| 12 | | 49ers | 9/20/2020 | 1-0 | @ | W 31-13 | 1.000 | 4 | 17 | 359 | 277 | 53.8 | |||
| 13 | | 49ers | 9/9/2024 | 1-0 | vs | W 32-19 | 1.000 | 2 | 24 | 401 | 266 | 46.2 | |||
| 14 | | 49ers | 9/29/2024 | 1-0 | vs | W 30-13 | 1.000 | 3 | 19 | 431 | 216 | 53.8 | |||
| Average | .714 | 3.4 | 20.1 | 375.2 | 327.4 | ||||||||||
| Total | 10-4 | .714 | 47 | 281 | 5,253 | 4,584 |
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Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
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NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
