The Florida Panthers had the highest goal differential by a team in 2021-22, with a differential of 95 goals.

TEAM	DIFF	SEASON	GP	W	L	OTL	PTS	PTS%	G	GA	PP%	PK%	S/GP	SA/GP
Florida Panthers	95	2021-22	82	58	18	6	122	.744	337	242	24.4	79.5	37.34	30.67
Calgary Flames	85	2021-22	82	50	21	11	111	.677	291	206	22.9	83.2	35.46	28.95
Carolina Hurricanes	77	2021-22	82	54	20	8	116	.707	277	200	22.0	88.0	34.12	28.17
Colorado Avalanche	76	2021-22	82	56	19	7	119	.726	308	232	24.0	79.7	35.05	32.01
St. Louis Blues	70	2021-22	82	49	22	11	109	.665	309	239	27.0	84.1	30.39	31.60
Toronto Maple Leafs	60	2021-22	82	54	21	7	115	.701	312	252	27.3	82.1	34.57	30.62
Tampa Bay Lightning	57	2021-22	82	51	23	8	110	.671	285	228	23.9	80.6	30.91	29.77
Minnesota Wild	56	2021-22	82	53	22	7	113	.689	305	249	20.5	76.1	32.51	31.43
Pittsburgh Penguins	47	2021-22	82	46	25	11	103	.628	269	222	20.2	84.4	34.74	31.41
New York Rangers	46	2021-22	82	52	24	6	110	.671	250	204	25.2	82.3	29.17	30.83
Boston Bruins	35	2021-22	82	51	26	5	107	.652	253	218	21.2	81.3	36.12	28.71
Edmonton Oilers	34	2021-22	82	49	27	6	104	.634	285	251	26.0	79.4	34.02	32.28
Washington Capitals	28	2021-22	82	44	26	12	100	.610	270	242	18.8	80.4	31.43	29.00
Vegas Golden Knights	18	2021-22	82	43	31	8	94	.573	262	244	18.4	77.4	34.51	29.98
Vancouver Canucks	15	2021-22	82	40	30	12	92	.561	246	231	23.5	74.9	31.98	31.85
Nashville Predators	12	2021-22	82	45	30	7	97	.591	262	250	24.4	79.2	29.74	32.27
Los Angeles Kings	3	2021-22	82	44	27	11	99	.604	235	232	16.1	76.7	34.94	28.55
New York Islanders	-2	2021-22	82	37	35	10	84	.512	229	231	22.1	84.2	28.87	32.55
Winnipeg Jets	-3	2021-22	82	39	32	11	89	.543	250	253	21.1	75.0	32.26	33.18
Dallas Stars	-11	2021-22	82	46	30	6	98	.598	233	244	22.4	79.0	30.32	31.04
Anaheim Ducks	-38	2021-22	82	31	37	14	76	.463	228	266	21.9	80.8	29.18	33.23
Columbus Blue Jackets	-39	2021-22	82	37	38	7	81	.494	258	297	18.6	78.6	30.04	35.21
Ottawa Senators	-40	2021-22	82	33	42	7	73	.445	224	264	19.3	80.3	30.04	33.41
San Jose Sharks	-50	2021-22	82	32	37	13	77	.470	211	261	19.0	85.2	29.27	31.98
New Jersey Devils	-57	2021-22	82	27	46	9	63	.384	245	302	15.6	80.2	31.24	30.98