18 players are tied for the most career hat tricks by an active defenseman, with 1 hat trick. The first three are Simon Nemec, Cale Makar and Jakob Chychrun.

Interpreted as:

active defensemen with most regular-season hat tricks

	NAME	HT	GP	G	A	P	+/-	PIM	PPG	PPA	SHG	SHA	GWG	OTG	S	S%	FOW	FO	FOW%	HIT	BKS	TKA	GVA	TOI/GP
1	Simon Nemec S. Nemec	1	109	9	27	36	-10	59	0	4	0	0	3	1	131	6.9	0	0		29	166	28	66	18:33
2	Cale Makar C. Makar	1	417	125	332	457	+158	120	41	145	3	4	27	6	1,180	10.6	0	0		354	587	308	324	24:50
3	Jakob Chychrun J. Chychrun	1	564	104	180	284	-39	383	36	44	0	0	17	4	1,373	7.6	0	0		650	846	202	463	21:22
4	Tony DeAngelo T. DeAngelo	1	429	53	184	237	-37	364	13	80	0	0	8	4	887	6.0	1	1	100.0	293	452	116	377	19:17
5	MacKenzie Weegar M. Weegar	1	574	59	196	255	+94	417	8	40	1	8	9	1	1,123	5.3	1	2	50.0	1,273	1,038	348	621	21:05
6	Zach Werenski Z. Werenski	1	590	120	285	405	+12	146	26	97	2	3	17	7	1,675	7.2	0	0		318	781	292	432	23:59
7	Brandon Montour B. Montour	1	619	88	217	305	+24	462	17	77	3	1	21	5	1,407	6.3	0	0		690	698	191	455	21:21
8	Erik Gustafsson E. Gustafsson	1	515	47	193	240	-15	163	7	66	0	0	6	2	786	6.0	0	1	0.0	454	504	155	391	18:31
9	Jaccob Slavin J. Slavin	1	747	55	244	299	+166	94	7	21	4	14	9	3	1,288	4.3	0	1	0.0	433	1,244	701	454	22:26
10	Hampus Lindholm H. Lindholm	1	777	74	245	319	+141	457	15	69	1	4	13	3	1,318	5.6	2	8	25.0	701	999	274	662	22:21
11	Rasmus Ristolainen R. Ristolainen	1	776	56	248	304	-179	383	15	105	1	4	8	5	1,455	3.8	1	2	50.0	1,900	1,254	192	425	22:39
12	Nikita Zadorov N. Zadorov	1	747	52	124	176	+39	882	2	7	0	3	5	1	908	5.7	1	1	100.0	2,061	807	221	505	18:28
13	Dougie Hamilton D. Hamilton	1	853	155	353	508	+74	536	49	118	1	2	34	9	2,440	6.4	1	4	25.0	993	944	257	704	20:37
14	Justin Faulk J. Faulk	1	1,003	136	335	471	-67	488	49	103	3	5	33	4	2,331	5.8	0	1	0.0	1,591	1,373	580	685	23:00
15	Cam Fowler C. Fowler	1	1,065	105	397	502	-120	273	40	147	4	6	19	5	1,669	6.3	2	3	66.7	483	1,447	352	666	23:07
16	Jared Spurgeon J. Spurgeon	1	956	118	302	420	+120	164	35	100	0	6	23	5	1,565	7.5	1	3	33.3	825	1,649	269	335	22:05
17	Erik Karlsson E. Karlsson	1	1,105	201	682	883	-116	492	44	264	2	5	38	12	3,014	6.7	0	4	0.0	780	1,450	863	1,316	25:12
18	Shea Weber S. Weber	1	1,038	224	365	589	+79	714	106	133	5	6	35	7	2,765	8.1	0	0		2,212	1,691	372	737	24:03