Ron Francis has recorded the most career points against the Sabres, with 114 points.

Interpreted as:

most points by a player vs buffalo sabres all-time

	NAME	P	GP	G	A	+/-	PIM	PPG	PPA	SHG	SHA	GWG	OTG	S	S%	FOW	FO	FOW%	HIT	BKS	TKA	GVA	TOI/GP
1	Ron Francis R. Francis	114	128	36	78	-12	70	12	32	1	0	7	1	270	13.3	186	325	57.2	8	8	11	13	18:49
2	Ray Bourque R. Bourque	113	128	27	86	+32	86	10	41	2	6	5	0	471	5.7	0	0		5	6	4	5	26:21
3	Jaromir Jagr J. Jagr	109	91	46	63	+24	80	13	21	1	0	4	1	317	14.5	0	1	0.0	12	15	31	79	19:28
4	Michel Goulet M. Goulet	100	84	38	62	+10	56	11	19	2	0	7	0	259	14.7
5	Peter Stastny P. Stastny	92	78	41	51	+1	46	14	16	1	1	2	0	190	21.6
6	Daniel Alfredsson D. Alfredsson	89	93	44	45	+23	22	11	15	1	0	9	1	293	15.0	10	33	30.3	64	43	52	65	20:28
7	Sidney Crosby S. Crosby	86	63	30	56	+15	26	10	25	0	0	5	2	193	15.5	743	1,374	54.1	41	24	31	61	20:25
8	Wayne Gretzky W. Gretzky	83	55	27	56	+10	6	4	19	2	2	5	0	173	15.6
9	Mark Messier M. Messier	80	73	25	55	+7	66	7	20	2	1	6	1	161	15.5	231	385	60.0	8	10	9	24	19:40
10	Joe Sakic J. Sakic	75	64	28	47	-13	18	10	19	1	2	4	0	213	13.1	111	199	55.8	7	5	10	9	21:01
11	Guy Lafleur G. Lafleur	75	82	29	46	+2	34	7	15	0	0	3	0	221	13.1
12	Mark Recchi M. Recchi	74	89	27	47	-23	44	8	19	0	2	5	1	199	13.6	54	105	51.4	45	20	20	31	18:22
13	Evgeni Malkin E. Malkin	73	56	22	51	+15	56	9	24	0	0	4	0	190	11.6	293	574	51.0	21	16	32	58	19:20
14	Jason Spezza J. Spezza	73	70	23	50	+25	48	8	20	1	0	6	0	173	13.3	621	1,151	54.0	17	19	44	63	17:18
15	Mats Sundin M. Sundin	73	85	28	45	-15	99	12	17	0	1	2	1	252	11.1	578	1,058	54.6	39	19	11	45	20:02
16	Alex Ovechkin A. Ovechkin	71	68	42	29	-3	71	13	15	0	0	5	1	355	11.8	6	11	54.5	168	14	26	64	20:00
17	Adam Oates A. Oates	70	65	19	51	-3	12	7	19	1	1	4	0	143	13.3	165	288	57.3	2	12	7	10	21:39
18	Mario Lemieux M. Lemieux	70	40	29	41	+5	42	14	11	0	0	4	0	190	15.3	70	126	55.6	1	1	1	7	21:54
19	Kevin Dineen K. Dineen	70	82	37	33	-2	170	12	12	3	1	6	0	222	16.7	0	0		9	2	1	0	12:15
20	Marcel Dionne M. Dionne	70	65	32	38	-8	25	7	11	1	0	4	0	235	13.6
21	Phil Esposito P. Esposito	69	51	39	30	+4	25	16	11	5	0	4	0	210	18.6
22	Brad Marchand B. Marchand	68	67	27	41	+25	54	4	12	3	2	4	2	179	15.1	11	38	28.9	54	23	46	47	17:20
23	Steve Yzerman S. Yzerman	67	41	26	41	+10	34	9	13	3	3	3	1	138	18.8	42	67	62.7	3	3	1	3	18:48
24	Larry Robinson L. Robinson	67	98	15	52	+38	58	4	20	1	0	4	0	154	9.7
25	Stephane Richer S. Richer	66	73	35	31	+11	55	7	13	1	2	8	0	227	15.4	0	0		0	1	3	3	12:44