The Florida Panthers had the most wins by a team in 2021-22, with 58 wins.

	TEAM	W	SEASON	GP	L	OTL	PTS	PTS%	SOW	SOL	G	GA	DIFF	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Panthers	58	2021-22	82	18	6	122	.744	3	4	337	242	95	24.4	79.5	37.34	11.0	30.67	.904
2	Avalanche	56	2021-22	82	19	7	119	.726	4	2	308	232	76	24.0	79.7	35.05	10.7	32.01	.912
3	Maple Leafs	54	2021-22	82	21	7	115	.701	3	1	312	252	60	27.3	82.1	34.57	11.0	30.62	.900
4	Hurricanes	54	2021-22	82	20	8	116	.707	1	2	277	200	77	22.0	88.0	34.12	9.9	28.17	.913
5	Wild	53	2021-22	82	22	7	113	.689	5	4	305	249	56	20.5	76.1	32.51	11.4	31.43	.903
6	Rangers	52	2021-22	82	24	6	110	.671	4	3	250	204	46	25.2	82.3	29.17	10.5	30.83	.919
7	Bruins	51	2021-22	82	26	5	107	.652	2	2	253	218	35	21.2	81.3	36.12	8.5	28.71	.907
8	Lightning	51	2021-22	82	23	8	110	.671	2	5	285	228	57	23.9	80.6	30.91	11.2	29.77	.907
9	Flames	50	2021-22	82	21	11	111	.677	2	2	291	206	85	22.9	83.2	35.46	10.0	28.95	.913
10	Blues	49	2021-22	82	22	11	109	.665	2	3	309	239	70	27.0	84.1	30.39	12.4	31.60	.908
11	Oilers	49	2021-22	82	27	6	104	.634	5	1	285	251	34	26.0	79.4	34.02	10.2	32.28	.905
12	Stars	46	2021-22	82	30	6	98	.598	5	2	233	244	-11	22.4	79.0	30.32	9.4	31.04	.904
13	Penguins	46	2021-22	82	25	11	103	.628	3	7	269	222	47	20.2	84.4	34.74	9.4	31.41	.914
14	Predators	45	2021-22	82	30	7	97	.591	4	2	262	250	12	24.4	79.2	29.74	10.7	32.27	.906
15	Kings	44	2021-22	82	27	11	99	.604	4	4	235	232	3	16.1	76.7	34.94	8.2	28.55	.901
16	Capitals	44	2021-22	82	26	12	100	.610	5	3	270	242	28	18.8	80.4	31.43	10.5	29.00	.898
17	Golden Knights	43	2021-22	82	31	8	94	.573	4	4	262	244	18	18.4	77.4	34.51	9.3	29.98	.901
18	Canucks	40	2021-22	82	30	12	92	.561	3	5	246	231	15	23.5	74.9	31.98	9.4	31.85	.912
19	Jets	39	2021-22	82	32	11	89	.543	2	4	250	253	-3	21.1	75.0	32.26	9.5	33.18	.907
20	Islanders	37	2021-22	82	35	10	84	.512	2	6	229	231	-2	22.1	84.2	28.87	9.7	32.55	.913
21	Blue Jackets	37	2021-22	82	38	7	81	.494	4	3	258	297	-39	18.6	78.6	30.04	10.5	35.21	.897
22	Senators	33	2021-22	82	42	7	73	.445	3	2	224	264	-40	19.3	80.3	30.04	9.1	33.41	.904
23	Red Wings	32	2021-22	82	40	10	74	.451	3	2	227	310	-83	16.3	73.8	29.44	9.4	33.67	.888
24	Sabres	32	2021-22	82	39	11	75	.457	3	3	229	287	-58	21.2	76.4	29.89	9.3	32.95	.894
25	Sharks	32	2021-22	82	37	13	77	.470	3	3	211	261	-50	19.0	85.2	29.27	8.8	31.98	.900