Between the 1999-00 and 2008-09 seasons, the Washington Capitals had the highest goal differential by a team in a game, with a differential of 10 goals against the Panthers on January 11, 2003.

NHL team highest goals diff in a regular-season game 2000s

	TEAM	DIFF	DATE	TM		OPP	RESULT	G	GA	PPG	PPO	OPP PPG	OPP PPO	S	SA
1	Capitals	10	1/11/2003	WSH	vs	FLA	W 12-2	12	2	3	4	0	4	40	26
2	Hurricanes	9	4/7/2009	CAR	vs	NYI	W 9-0	9	0	4	11	0	1	57	12
3	Sabres	9	1/18/2008	BUF	vs	ATL	W 10-1	10	1	3	9	0	6	49	24
4	Sabres	9	1/14/2006	BUF	vs	LAK	W 10-1	10	1	3	9	0	7	34	33
5	Thrashers	9	11/12/2005	ATL	@	CAR	W 9-0	9	0	4	13	0	8	36	19
6	Lightning	9	11/8/2003	TBL	vs	PIT	W 9-0	9	0	1	8	0	4	42	15
7	Devils	9	10/28/2000	NJD	@	PIT	W 9-0	9	0	1	3	0	0	42	21
8	Devils	9	3/10/2000	NJD	@	ATL	W 9-0	9	0	2	4	0	1	38	19
9	Predators	8	2/28/2009	NSH	vs	DET	W 8-0	8	0	1	3	0	2	23	30
10	Stars	8	2/6/2009	DAL	vs	NYR	W 10-2	10	2	4	9	1	4	39	22
11	Sabres	8	1/27/2009	BUF	@	EDM	W 10-2	10	2	3	6	1	8	37	38
12	Capitals	8	3/3/2008	WSH	vs	BOS	W 10-2	10	2	4	7	1	7	34	27
13	Panthers	8	2/5/2008	FLA	@	TOR	W 8-0	8	0	3	4	0	5	26	24
14	Maple Leafs	8	1/4/2007	TOR	@	BOS	W 10-2	10	2	1	5	1	7	39	31
15	Coyotes	8	12/30/2006	PHX	vs	SJS	W 8-0	8	0	2	6	0	4	26	40
16	Lightning	8	12/7/2006	TBL	vs	ATL	W 8-0	8	0	2	8	0	4	38	21
17	Sabres	8	10/17/2006	BUF	vs	PHI	W 9-1	9	1	3	6	0	5	37	38
18	Stars	8	11/4/2005	DAL	vs	CHI	W 9-1	9	1	3	12	0	5	40	19
19	Senators	8	10/29/2005	OTT	@	TOR	W 8-0	8	0	1	8	0	6	33	27
20	Maple Leafs	8	10/14/2005	TOR	@	ATL	W 9-1	9	1	7	16	0	7	34	20
21	Senators	8	1/24/2004	OTT	vs	NYR	W 9-1	9	1	3	7	0	3	25	29
22	Canadiens	8	1/10/2004	MTL	@	PIT	W 8-0	8	0	4	6	0	5	34	25
23	Canucks	8	2/25/2003	VAN	vs	ATL	W 8-0	8	0	3	7	0	4	31	23
24	Sharks	8	3/30/2002	SJS	vs	CBJ	W 10-2	10	2	3	3	0	3	31	34
25	Bruins	8	2/4/2002	BOS	@	CBJ	W 8-0	8	0	0	1	0	3	25	30