Between the 2009-10 and 2018-19 seasons, the Columbus Blue Jackets had the highest goal differential by a team in a game, with a differential of 10 goals against the Canadiens on November 4, 2016.

NHL team highest goals diff in a regular-season game 2010s

	TEAM	DIFF	DATE	TM		OPP	RESULT	G	GA	PPG	PPO	OPP PPG	OPP PPO	S	SA
1	Blue Jackets	10	11/4/2016	CBJ	vs	MTL	W 10-0	10	0	4	5	0	1	40	30
2	Canadiens	9	12/2/2017	MTL	vs	DET	W 10-1	10	1	1	2	0	1	34	23
3	Blackhawks	9	10/5/2017	CHI	vs	PIT	W 10-1	10	1	0	6	1	2	44	29
4	Canadiens	9	12/10/2016	MTL	vs	COL	W 10-1	10	1	1	2	0	3	36	16
5	Bruins	9	1/5/2012	BOS	vs	CGY	W 9-0	9	0	1	2	0	2	42	25
6	Penguins	8	10/25/2018	PIT	@	CGY	W 9-1	9	1	2	2	0	3	36	39
7	Ducks	8	1/15/2014	ANA	vs	VAN	W 9-1	9	1	6	11	1	3	44	32
8	Bruins	8	3/19/2012	BOS	vs	TOR	W 8-0	8	0	2	2	0	2	24	13
9	Bruins	8	12/23/2011	BOS	vs	FLA	W 8-0	8	0	2	5	0	2	35	30
10	Flames	8	2/14/2011	CGY	@	COL	W 9-1	9	1	1	4	1	3	33	23
11	Sharks	8	1/18/2010	SJS	vs	CGY	W 9-1	9	1	2	5	0	3	46	22
12	Red Wings	8	11/11/2009	DET	@	CBJ	W 9-1	9	1	2	4	0	2	39	26
13	Jets	7	3/8/2019	WPG	@	CAR	W 8-1	8	1	1	2	0	3	29	29
14	Canadiens	7	2/26/2019	MTL	@	DET	W 8-1	8	1	0	0	0	5	34	29
15	Sabres	7	11/3/2018	BUF	vs	OTT	W 9-2	9	2	1	3	0	1	41	29
16	Capitals	7	10/3/2018	WSH	vs	BOS	W 7-0	7	0	4	6	0	2	37	25
17	Maple Leafs	7	12/19/2017	TOR	vs	CAR	W 8-1	8	1	3	3	0	4	36	33
18	Golden Knights	7	10/27/2017	VGK	vs	COL	W 7-0	7	0	1	5	0	3	21	32
19	Panthers	7	3/25/2017	FLA	vs	CHI	W 7-0	7	0	1	5	0	3	31	25
20	Blue Jackets	7	2/25/2017	CBJ	vs	NYI	W 7-0	7	0	0	2	0	0	45	24
21	Penguins	7	12/12/2016	PIT	vs	ARI	W 7-0	7	0	2	7	0	3	34	32
22	Kings	7	11/8/2016	LAK	@	TOR	W 7-0	7	0	0	4	0	1	43	19
23	Kings	7	2/9/2016	LAK	@	BOS	W 9-2	9	2	3	3	1	3	57	37
24	Islanders	7	2/7/2016	NYI	vs	EDM	W 8-1	8	1	2	4	0	1	31	31
25	Sharks	7	1/9/2016	SJS	vs	TOR	W 7-0	7	0	0	4	0	3	31	28