Between the 2005-06 and 2021-22 seasons, the Columbus Blue Jackets had the highest goal differential by a team in a game, with a differential of 10 goals versus the Canadiens on November 4, 2016.

biggest win margin in one regular-season game 2005-06 to 2021-22

	TEAM	DIFF	DATE	TM		OPP	RESULT	G	GA	PPG	PPO	OPP PPG	OPP PPO	S	SA
1	Blue Jackets	10	11/4/2016	CBJ	vs	MTL	W 10-0	10	0	4	5	0	1	40	30
2	Penguins	9	3/27/2022	PIT	vs	DET	W 11-2	11	2	3	6	1	5	35	35
3	Rangers	9	3/17/2021	NYR	vs	PHI	W 9-0	9	0	1	4	0	2	29	26
4	Canadiens	9	12/2/2017	MTL	vs	DET	W 10-1	10	1	1	2	0	1	34	23
5	Blackhawks	9	10/5/2017	CHI	vs	PIT	W 10-1	10	1	0	6	1	2	44	29
6	Canadiens	9	12/10/2016	MTL	vs	COL	W 10-1	10	1	1	2	0	3	36	16
7	Bruins	9	1/5/2012	BOS	vs	CGY	W 9-0	9	0	1	2	0	2	42	25
8	Hurricanes	9	4/7/2009	CAR	vs	NYI	W 9-0	9	0	4	11	0	1	57	12
9	Sabres	9	1/18/2008	BUF	vs	ATL	W 10-1	10	1	3	9	0	6	49	24
10	Sabres	9	1/14/2006	BUF	vs	LAK	W 10-1	10	1	3	9	0	7	34	33
11	Thrashers	9	11/12/2005	ATL	@	CAR	W 9-0	9	0	4	13	0	8	36	19
12	Canadiens	8	4/29/2022	MTL	vs	FLA	W 10-2	10	2	1	2	1	1	37	39
13	Flames	8	4/16/2022	CGY	vs	ARI	W 9-1	9	1	0	2	0	2	41	26
14	Predators	8	3/5/2022	NSH	@	SJS	W 8-0	8	0	1	4	0	3	36	20
15	Blues	8	4/9/2021	STL	vs	MIN	W 9-1	9	1	1	2	0	2	38	25
16	Avalanche	8	1/15/2021	COL	vs	STL	W 8-0	8	0	5	7	0	4	38	21
17	Penguins	8	10/25/2018	PIT	@	CGY	W 9-1	9	1	2	2	0	3	36	39
18	Ducks	8	1/15/2014	ANA	vs	VAN	W 9-1	9	1	6	11	1	3	44	32
19	Bruins	8	3/19/2012	BOS	vs	TOR	W 8-0	8	0	2	2	0	2	24	13
20	Bruins	8	12/23/2011	BOS	vs	FLA	W 8-0	8	0	2	5	0	2	35	30
21	Flames	8	2/14/2011	CGY	@	COL	W 9-1	9	1	1	4	1	3	33	23
22	Sharks	8	1/18/2010	SJS	vs	CGY	W 9-1	9	1	2	5	0	3	46	22
23	Red Wings	8	11/11/2009	DET	@	CBJ	W 9-1	9	1	2	4	0	2	39	26
24	Predators	8	2/28/2009	NSH	vs	DET	W 8-0	8	0	1	3	0	2	23	30
25	Stars	8	2/6/2009	DAL	vs	NYR	W 10-2	10	2	4	9	1	4	39	22