Between the 1999-00 and 2008-09 seasons, Andrew Brunette had the most games, with 729 games.

Interpreted as:

most regular-season games played by a player, 2000s

	NAME	GP	G	A	P	+/-	PIM	PPG	PPA	SHG	SHA	GWG	OTG	S	S%	FOW	FO	FOW%	HIT	BKS	TKA	GVA	TOI/GP
1	Andrew Brunette A. Brunette	729	184	344	528	-47	232	77	139	0	0	22	0	1,049	17.5	138	281	49.1	199	164	225	293	15:58
2	Olli Jokinen O. Jokinen	725	228	269	497	-70	744	75	100	12	2	42	11	2,211	10.3	4,784	10,531	45.4	726	235	306	408	19:11
3	Martin Skoula M. Skoula	724	41	144	185	+13	318	16	43	0	2	5	1	752	5.5	2	3	66.7	697	626	237	404	19:47
4	Markus Naslund M. Naslund	722	296	362	658	+12	505	100	176	3	1	41	5	2,378	12.4	23	60	38.3	270	158	402	409	18:45
5	Vinny Prospal V. Prospal	721	177	346	523	-61	390	58	118	0	2	25	4	1,689	10.5	2,013	3,935	51.2	543	226	414	349	17:55
6	Nicklas Lidstrom N. Lidstrom	718	127	447	574	+232	278	68	237	6	10	21	3	1,909	6.7	0	0		331	737	366	529	27:49
7	Shane Doan S. Doan	716	236	325	561	-5	676	76	125	6	12	38	4	2,061	11.5	668	1,619	41.3	1,652	183	445	343	19:30
8	Patrick Marleau P. Marleau	716	242	291	533	-14	265	80	118	7	3	47	5	1,696	14.3	3,899	8,358	46.6	657	120	310	567	17:41
9	Miroslav Satan M. Satan	714	249	287	536	-11	326	85	100	13	8	32	1	1,944	12.8	308	597	51.6	253	221	347	529	19:31
10	Sean O'Donnell S. O'Donnell	713	17	115	132	+75	944	2	10	1	10	7	4	500	3.4	9	20	45.0	651	622	293	535	20:05
11	Chris Drury C. Drury	712	220	314	534	-7	367	88	129	8	7	43	5	1,839	12.0	6,145	11,241	54.7	456	508	501	389	18:41
12	Daymond Langkow D. Langkow	712	208	312	520	+97	367	61	103	8	10	35	2	1,733	12.0	5,098	11,140	45.8	552	379	527	482	19:02
13	Mark Recchi M. Recchi	709	212	388	600	-13	395	83	162	6	7	34	4	1,596	13.3	774	1,572	49.2	733	241	300	470	19:25
14	Marian Hossa M. Hossa	708	324	364	688	+95	421	102	166	16	6	54	7	2,481	13.1	47	144	32.6	714	184	535	459	19:16
15	Jarome Iginla J. Iginla	708	347	371	718	+78	544	112	139	10	5	57	4	2,561	13.5	1,868	3,512	53.2	794	204	348	472	21:09
16	John Madden J. Madden	708	140	156	296	+37	193	6	9	17	10	19	1	1,529	9.2	5,685	11,226	50.6	515	385	608	350	16:56
17	Scott Gomez S. Gomez	706	148	430	578	+60	458	38	150	1	1	27	3	1,914	7.7	4,520	9,087	49.7	303	153	501	520	17:43
18	Vincent Lecavalier V. Lecavalier	705	289	352	641	-70	538	83	135	13	9	45	5	2,268	12.7	5,517	11,901	46.4	776	192	335	575	19:59
19	Craig Conroy C. Conroy	704	142	283	425	+76	441	25	69	13	13	21	2	1,118	12.7	6,635	12,434	53.4	724	357	412	487	17:22
20	Brian Rolston B. Rolston	704	223	269	492	+36	327	72	124	23	9	49	6	2,422	9.2	2,682	5,718	46.9	439	246	298	300	19:30
21	Hal Gill H. Gill	703	26	109	135	+75	690	0	1	0	6	1	0	827	3.1	0	1	0.0	1,127	796	210	502	19:23
22	Milan Hejduk M. Hejduk	701	298	311	609	+129	248	110	106	6	5	47	9	1,955	15.2	237	551	43.0	302	248	436	313	19:22
23	Petr Sykora P. Sykora	701	236	285	521	+46	327	81	106	4	1	38	1	2,058	11.5	309	658	47.0	176	160	288	369	17:14
24	Joe Thornton J. Thornton	700	246	548	794	+117	743	89	199	3	2	42	8	1,612	15.3	7,457	14,390	51.8	594	185	476	671	21:05
25	Darryl Sydor D. Sydor	695	43	201	244	+2	298	22	91	0	1	4	2	980	4.4	0	4	0.0	467	876	197	404	19:59