Since 1979-80, the Edmonton Oilers have the most wins by a team when the goal differential has been 5 or above goals, with 167 wins.

Interpreted as:

most regular-season wins by 5+ goals since 1980

	TEAM	W	DIFF	GP	L	T	OTL	PTS	PTS%	SOW	SOL	G	GA	PP%	PK%	S/GP	S%	SA/GP	SV%
1	Oilers	167	981	167	0	0	0	334	1.000	0	0	1,270	289	36.3	88.7	33.54	22.7	30.02	.942
2	Flames	151	901	151	0	0	0	302	1.000	0	0	1,132	231	38.0	89.2	35.61	21.1	27.35	.944
3	Sabres	143	827	143	0	0	0	286	1.000	0	0	1,019	192	35.8	91.9	33.62	21.2	27.25	.951
4	Penguins	140	801	140	0	0	0	280	1.000	0	0	1,015	214	40.3	91.3	34.44	21.1	29.17	.948
5	Avalanche	139	795	139	0	0	0	278	1.000	0	0	972	177	38.4	92.0	34.04	20.5	27.37	.953
6	Rangers	130	727	130	0	0	0	260	1.000	0	0	902	175	35.9	89.5	33.65	20.6	28.97	.954
7	Capitals	129	758	129	0	0	0	258	1.000	0	0	923	165	39.3	90.9	33.29	21.5	27.58	.954
8	Bruins	129	749	129	0	0	0	258	1.000	0	0	897	148	40.2	90.4	33.50	20.8	25.75	.955
9	Red Wings	128	746	128	0	0	0	256	1.000	0	0	918	172	34.8	90.5	33.97	21.1	25.68	.948
10	Flyers	128	730	128	0	0	0	256	1.000	0	0	889	159	36.1	90.0	34.23	20.3	27.19	.954
11	Blues	126	695	126	0	0	0	252	1.000	0	0	876	181	39.1	89.7	31.98	21.7	27.43	.948
12	Canadiens	125	740	125	0	0	0	250	1.000	0	0	918	178	38.2	88.1	34.11	21.5	26.02	.945
13	Kings	123	710	123	0	0	0	246	1.000	0	0	893	183	37.5	88.9	34.84	20.8	28.58	.948
14	Stars	118	672	118	0	0	0	236	1.000	0	0	831	159	39.9	91.6	33.84	20.8	27.43	.951
15	Islanders	116	678	116	0	0	0	232	1.000	0	0	838	160	34.0	91.3	32.90	22.0	29.03	.952
16	Maple Leafs	115	648	115	0	0	0	230	1.000	0	0	773	125	37.1	94.2	33.04	20.3	29.11	.963
17	Canucks	105	592	105	0	0	0	210	1.000	0	0	705	113	35.4	90.7	32.30	20.8	27.01	.960
18	Devils	101	558	101	0	0	0	202	1.000	0	0	668	110	36.1	90.0	34.16	19.4	25.60	.957
19	Blackhawks	98	555	98	0	0	0	196	1.000	0	0	684	129	34.1	88.4	33.30	21.0	28.08	.953
20	Hurricanes	85	488	85	0	0	0	170	1.000	0	0	607	119	39.7	89.6	33.59	21.3	27.16	.948
21	Coyotes	80	470	80	0	0	0	160	1.000	0	0	562	92	30.7	89.6	33.34	21.1	29.18	.961
22	Senators	71	401	71	0	0	0	142	1.000	0	0	475	74	32.0	94.3	32.99	20.3	27.30	.962
23	Sharks	68	379	68	0	0	0	136	1.000	0	0	439	60	33.9	91.8	32.57	19.8	27.60	.968
24	Lightning	65	361	65	0	0	0	130	1.000	0	0	420	59	41.1	92.9	31.74	20.4	26.92	.966
25	Panthers	57	311	57	0	0	0	114	1.000	0	0	372	61	35.8	90.4	33.82	19.3	30.07	.964